{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895462330752.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1177/089686089601600114"}},{"identifier":{"@type":"URI","@value":"https://journals.sagepub.com/doi/pdf/10.1177/089686089601600114"}}],"dc:title":[{"@value":"The Fate of Leached Di(2-Ethylhexyl)Phthalate in Patients Undergoing Capd Treatment"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec><jats:title>Objectives</jats:title><jats:p> To evaluate the degree of exposure to and the fate of di(2-ethylhexyl)phthalate (DE HP) and its major derivatives mono(2-ethylhexyl)phthalate (ME HP), 2-ethylhexanol (2-EH), and phthalic acid (PA) in patients undergoing regular continuous ambulatory peritoneal dialysis (CAPD) during a 4-hour dwell period. </jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p> Prospective, controlled. </jats:p></jats:sec><jats:sec><jats:title>Setting</jats:title><jats:p> Teaching hospital, Department of Nephrology. </jats:p></jats:sec><jats:sec><jats:title>Participants</jats:title><jats:p> Seven elderly patients on stable CAPD using Fresenius instruments and dialysate and 6 agematched healthy controls. </jats:p></jats:sec><jats:sec><jats:title>Interventions</jats:title><jats:p> During a routinely performed peritoneal equilibration test (PET), blood and dialysate samples were drawn before and 120 and 240 min after the dwell was started. In addition, blood samples were taken from a group of volunteers participating in a pharmacological study. </jats:p></jats:sec><jats:sec><jats:title>Measurements</jats:title><jats:p> Quantitative analysis of DE HP and its hydrolysis products was performed by selected ion-monitoring gas chromatography/mass spectrometry, operating the mass spectrometer in a combined positive and negative ion chemical ionization mode. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Serum concentrations of DE HP and PA were significantly higher in patients (median: 0.079 I1g/mL, range: 0.032 -0.210 I1g/mL; and 0.167 I1g/mL, range: 0.097 0.231 I1g/mL, respectively) than in controls [0.0195 I1g/mL, range: 0.016 -0.025I1g/mL (p = 0.0027) and 0.0120 I1g/mL, range: 0.006 -0.034I1g/mL (p = 0.0026), respectively]. Concentration of ME HP in the fluid of CAPD bags prior to use was four times higher than that of the parent compound. During the first 4 hours of dwell time, the concentrations of ME HP and 2-EH in dialysate consistently decreased from 0.177 (range: 0.137 -0.239119/ mL) to 0.022 I1g/mL (range: 0.005 -0.058 I1g/mL) (p = 0.017), and from 0.087 (range: 0.075 -0.097I1g/mL) to 0.05 I1g/mL (range: 0.023 0.064I1g/mL) (p = 0.017), respectively, while the concentration of DE HP remained stable. Remarkably high concentrations of PA (0.129 I1g/mL; range: 0.038 -0.466 I1g/mL) were found in CAPD bags prior to use, and these concentrations tended to increase during dwell time, without statistical significance, however (0.135I1g/mL; range: 0.073 -0.659I1g/mL, p = 0.062). </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> Patients on CAPD are regularly exposed to considerable amounts of phthalic ester derivatives, mainly to MEHPand PA. ME HP seems to bewellabsorbed by the peritoneal membrane. The long-term effects of this exposure remain to be elucidated. </jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825895462330756","@type":"Researcher","foaf:name":[{"@value":"Thomas Mettang"}],"jpcoar:affiliationName":[{"@value":"Robert Bosch Hospital, Department of Internal Medicine, Division of Nephrology, Stuttgart, University of Tübingen, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895462330755","@type":"Researcher","foaf:name":[{"@value":"Stefan Thomas"}],"jpcoar:affiliationName":[{"@value":"Robert Bosch Hospital, Department of Internal Medicine, Division of Nephrology, Stuttgart, University of Tübingen, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895462330754","@type":"Researcher","foaf:name":[{"@value":"Thomas Kiefer"}],"jpcoar:affiliationName":[{"@value":"Robert Bosch Hospital, Department of Internal Medicine, Division of Nephrology, Stuttgart, University of Tübingen, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895462330758","@type":"Researcher","foaf:name":[{"@value":"Frank-Peter Fischer"}],"jpcoar:affiliationName":[{"@value":"Robert Bosch Hospital, Department of Internal Medicine, Division of Nephrology, Stuttgart, University of Tübingen, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895462330752","@type":"Researcher","foaf:name":[{"@value":"Ulrich Kuhlmann"}],"jpcoar:affiliationName":[{"@value":"Robert Bosch Hospital, Department of Internal Medicine, Division of Nephrology, Stuttgart, University of Tübingen, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895462330753","@type":"Researcher","foaf:name":[{"@value":"Roman Wodarz"}],"jpcoar:affiliationName":[{"@value":"Department of Occupational and Social Medicine, University of Tübingen, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895462330757","@type":"Researcher","foaf:name":[{"@value":"Albert W. Rettenmeier"}],"jpcoar:affiliationName":[{"@value":"Department of Occupational and Social Medicine, University of Tübingen, Germany"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08968608"},{"@type":"EISSN","@value":"17184304"}],"prism:publicationName":[{"@value":"Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis"}],"dc:publisher":[{"@value":"SAGE Publications"}],"prism:publicationDate":"1996-01","prism:volume":"16","prism:number":"1","prism:startingPage":"58","prism:endingPage":"62"},"reviewed":"false","dc:rights":["https://journals.sagepub.com/page/policies/text-and-data-mining-license"],"url":[{"@id":"https://journals.sagepub.com/doi/pdf/10.1177/089686089601600114"}],"createdAt":"2020-02-25","modifiedAt":"2025-03-04","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001204457561216","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"No Immunotoxic Effect on T Cells with Di (2-Ethylhexyl) Phthalate in Male C57BL/6 Mice"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1177/089686089601600114"},{"@type":"CROSSREF","@value":"10.1265/ehpm.8.59_references_DOI_MmPxn9DcBUsA4P9ewuXwWBEVbMy"}]}