{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895475497216.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/hep.30988"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhep.30988"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/hep.30988"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/hep.30988"}},{"identifier":{"@type":"URI","@value":"https://journals.lww.com/10.1002/hep.30988"}},{"identifier":{"@type":"PMID","@value":"31610027"}}],"dc:title":[{"@value":"Cure With Interferon‐Free Direct‐Acting Antiviral Is Associated With Increased Survival in Patients With Hepatitis C Virus‐Related Hepatocellular Carcinoma From Both East and West"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec>\n                    <jats:title>Background and Aims</jats:title>\n                    <jats:p>Survival data among patients with hepatitis C virus (HCV)‐related hepatocellular carcinoma (HCC) after achieving sustained virologic response (SVR) with interferon‐free direct‐acting antivirals (DAAs) in both Asian and western countries are limited. Survival rates were compared between patients with HCV‐related HCC who were untreated for HCV and those who achieved SVR.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Approach and Results</jats:title>\n                    <jats:p>\n                      Using data from two U.S. and six Asian centers from 2005 to 2017, we categorized 1,676 patients who were mono‐infected with HCV‐related HCC into patients untreated for HCV (untreated group) and DAA‐treated patients with SVR (SVR group) and matched by propensity score matching (PSM); multivariable Cox regression with HCV treatment status as a time‐varying covariate was used to determine mortality risk and landmark analysis to avoid immortal time bias. There were 1,239 untreated patients and 437 patients with SVR. After PSM, background risks of the 321 pairs of matched patients were balanced (all\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                       > 0.05). After time‐varying adjustment for HCV treatment initiation compared with untreated patients, patients with SVR had significantly higher 5‐year overall survival (87.78% vs. 66.05%,\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                       < 0.001). Multivariable Cox regression showed that SVR was independently associated with a 63% lower risk of 5‐year all‐cause mortality (hazard ratio [HR], 0.37; 95% confidence interval [CI], 0.16‐0.83;\n                      <jats:italic toggle=\"yes\">P </jats:italic>\n                      = 0.016) and 66% lower risk of 5‐year liver‐related mortality (HR, 0.34; 95% CI, 0.13‐0.88;\n                      <jats:italic toggle=\"yes\">P </jats:italic>\n                      = 0.026) with similar trends after removing patients with liver transplants. Landmark analysis at 90, 180, and 360 days showed consistent results (HRs ranged 0.22 to 0.44, all\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                       < 0.05).\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion</jats:title>\n                    <jats:p>In this multinational consortium, patients with HCV‐related HCC who obtained SVR achieved a 60%‐70% improvement in 5‐year survival (both all‐cause and liver related) compared with patients untreated for HCV. Patients eligible for HCC therapy should also be considered for DAA therapy.</jats:p>\n                  </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825895475497228","@type":"Researcher","foaf:name":[{"@value":"Hansen Dang"}],"jpcoar:affiliationName":[{"@value":"Division of Gastroenterology and Hepatology,Department of Medicine,Stanford University Medical Center,Palo Alto,CA"},{"@value":"University of California,Davis, Davis,CA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497223","@type":"Researcher","foaf:name":[{"@value":"Yee Hui Yeo"}],"jpcoar:affiliationName":[{"@value":"Division of Gastroenterology and Hepatology,Department of Medicine,Stanford University Medical Center,Palo Alto,CA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497218","@type":"Researcher","foaf:name":[{"@value":"Satoshi Yasuda"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology,Ogaki Municipal Hospital,Ogaki,Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497216","@type":"Researcher","foaf:name":[{"@value":"Chung‐Feng Huang"}],"jpcoar:affiliationName":[{"@value":"Hepatobiliary Division,Department of Internal Medicine,Kaohsiung Medical University Hospital,Kaohsiung Medical University,Kaohsiung,Taiwan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497348","@type":"Researcher","foaf:name":[{"@value":"Etsuko Iio"}],"jpcoar:affiliationName":[{"@value":"Department of Virology and Liver Unit,Nagoya City University Graduate School of Medical Sciences,Nagoya,Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497219","@type":"Researcher","foaf:name":[{"@value":"Charles Landis"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology,University of Washington Medical Center,Seattle,WA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497225","@type":"Researcher","foaf:name":[{"@value":"Dae Won Jun"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology,Hanyang University,Seoul,South Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497349","@type":"Researcher","foaf:name":[{"@value":"Masaru Enomoto"}],"jpcoar:affiliationName":[{"@value":"Department of Hepatology,Osaka City University Graduate School of Medicine,Osaka,Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497221","@type":"Researcher","foaf:name":[{"@value":"Eiichi Ogawa"}],"jpcoar:affiliationName":[{"@value":"Department of General Internal Medicine,Kyushu University Hospital,Fukuoka,Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497227","@type":"Researcher","foaf:name":[{"@value":"Pei‐Chien Tsai"}],"jpcoar:affiliationName":[{"@value":"Hepatobiliary Division,Department of Internal Medicine,Kaohsiung Medical University Hospital,Kaohsiung Medical University,Kaohsiung,Taiwan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497088","@type":"Researcher","foaf:name":[{"@value":"An Le"}],"jpcoar:affiliationName":[{"@value":"Division of Gastroenterology and Hepatology,Department of Medicine,Stanford University Medical Center,Palo Alto,CA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497229","@type":"Researcher","foaf:name":[{"@value":"Matthew Liu"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology,University of Washington Medical Center,Seattle,WA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497345","@type":"Researcher","foaf:name":[{"@value":"Mayumi Maeda"}],"jpcoar:affiliationName":[{"@value":"Division of Gastroenterology and Hepatology,Department of Medicine,Stanford University Medical Center,Palo Alto,CA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497220","@type":"Researcher","foaf:name":[{"@value":"Brian Nguyen"}],"jpcoar:affiliationName":[{"@value":"Division of Gastroenterology and Hepatology,Department of Medicine,Stanford University Medical Center,Palo Alto,CA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497226","@type":"Researcher","foaf:name":[{"@value":"Nathan Ramrakhiani"}],"jpcoar:affiliationName":[{"@value":"Division of Gastroenterology and Hepatology,Department of Medicine,Stanford University Medical Center,Palo Alto,CA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497224","@type":"Researcher","foaf:name":[{"@value":"Linda Henry"}],"jpcoar:affiliationName":[{"@value":"Division of Gastroenterology and Hepatology,Department of Medicine,Stanford University Medical Center,Palo Alto,CA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497090","@type":"Researcher","foaf:name":[{"@value":"Ramsey Cheung"}],"jpcoar:affiliationName":[{"@value":"Division of Gastroenterology and Hepatology,Department of Medicine,Stanford University Medical Center,Palo Alto,CA"},{"@value":"Division of Gastroenterology and Hepatology,Veterans Affairs Palo Alto Health Care System,Palo Alto,CA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497346","@type":"Researcher","foaf:name":[{"@value":"Akihiro Tamori"}],"jpcoar:affiliationName":[{"@value":"Department of Hepatology,Osaka City University Graduate School of Medicine,Osaka,Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497217","@type":"Researcher","foaf:name":[{"@value":"Takashi Kumada"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology,Ogaki Municipal Hospital,Ogaki,Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497344","@type":"Researcher","foaf:name":[{"@value":"Yasuhito Tanaka"}],"jpcoar:affiliationName":[{"@value":"Department of Virology and Liver Unit,Nagoya City University Graduate School of Medical Sciences,Nagoya,Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497347","@type":"Researcher","foaf:name":[{"@value":"Ming‐Lung Yu"}],"jpcoar:affiliationName":[{"@value":"Hepatobiliary Division,Department of Internal Medicine,Kaohsiung Medical University Hospital,Kaohsiung Medical University,Kaohsiung,Taiwan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497089","@type":"Researcher","foaf:name":[{"@value":"Hidenori Toyoda"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology,Ogaki Municipal Hospital,Ogaki,Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895475497222","@type":"Researcher","foaf:name":[{"@value":"Mindie H. Nguyen"}],"jpcoar:affiliationName":[{"@value":"Division of Gastroenterology and Hepatology,Department of Medicine,Stanford University Medical Center,Palo Alto,CA"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"02709139"},{"@type":"EISSN","@value":"15273350"}],"prism:publicationName":[{"@value":"Hepatology"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2020-05-08","prism:volume":"71","prism:number":"6","prism:startingPage":"1910","prism:endingPage":"1922"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor","http://doi.wiley.com/10.1002/tdm_license_1.1"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fhep.30988"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/hep.30988"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/hep.30988"},{"@id":"https://journals.lww.com/10.1002/hep.30988"}],"createdAt":"2019-10-14","modifiedAt":"2026-01-26","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Asia","dc:title":"Asia"},{"@id":"https://cir.nii.ac.jp/all?q=Carcinoma,%20Hepatocellular","dc:title":"Carcinoma, Hepatocellular"},{"@id":"https://cir.nii.ac.jp/all?q=Sustained%20Virologic%20Response","dc:title":"Sustained Virologic 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