{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895545158784.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/apm.12541"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fapm.12541"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/apm.12541"}}],"dc:title":[{"@value":"Syphilis epidemiology in 1994–2013, molecular epidemiological strain typing and determination of macrolide resistance in <i>Treponema pallidum</i> in 2013–2014 in Tuva Republic, Russia"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The incidence of syphilis in the Tuva Republic (geographical centre of Asia), Russia has been exceedingly high historically. No detailed examinations and no molecular investigations of <jats:italic>Treponema pallidum</jats:italic> strains transmitted in the Tuva Republic, or in general, in Russia, were published internationally. We examined the syphilis epidemiology in 1994–2013, and the molecular epidemiology and macrolide resistance in <jats:italic>T. pallidum</jats:italic> strains in 2013–2014 in the Tuva Republic. Among 95 mainly primary or secondary syphilis patients, the <jats:italic>arp</jats:italic>,<jats:italic> tpr</jats:italic>,<jats:italic> tp0548</jats:italic> and 23S <jats:styled-content style=\"fixed-case\">rRNA</jats:styled-content> genes in 85 <jats:italic>polA</jats:italic> gene‐positive genital ulcer specimens were characterized. The syphilis incidence in Tuva Republic peaked in 1998 (1562), however declined to 177 in 2013. Among the 70 (82%) completely genotyped specimens, six molecular strain types were found. Strain type 14d/f accounted for 91%, but also 14c/f, 14d/g, 14b/f, 14i/f, 9d/f, and 4d/f were identified. Two (2.4%) specimens contained the 23S <jats:styled-content style=\"fixed-case\">rRNA</jats:styled-content> A2058G macrolide resistance mutation. This is the first internationally published typing study regarding <jats:italic>T. pallidum</jats:italic> in Russia, performed in the Tuva Republic with the highest syphilis incidence in Russia. The two molecular strain types 4d/f and 9d/f have previously been described only in Eastern and Northern China and for the first time, macrolide‐resistant syphilis was described in Russia.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825895545158786","@type":"Researcher","foaf:name":[{"@value":"Rafil Khairullin"}],"jpcoar:affiliationName":[{"@value":"Institute of Fundamental Medicine and Biology Kazan (Volga Region) Federal University Kazan Russia"},{"@value":"The State Research Center of Dermatology, Venereology and Cosmetology of The Russian Ministry of Health (SRCDVC) Moscow Russia"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895545158788","@type":"Researcher","foaf:name":[{"@value":"Denis Vorobyev"}],"jpcoar:affiliationName":[{"@value":"The State Research Center of Dermatology, Venereology and Cosmetology of The Russian Ministry of Health (SRCDVC) Moscow Russia"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895545158784","@type":"Researcher","foaf:name":[{"@value":"Andrey Obukhov"}],"jpcoar:affiliationName":[{"@value":"Tuvan Republican Skin and Venereal Diseases Dispensary Tuva Russia"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298341660249088","@type":"Researcher","foaf:name":[{"@value":"Ural‐Herel Kuular"}],"jpcoar:affiliationName":[{"@value":"Tuvan Republican Skin and Venereal Diseases Dispensary Tuva Russia"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895545158787","@type":"Researcher","foaf:name":[{"@value":"Anna Kubanova"}],"jpcoar:affiliationName":[{"@value":"The State Research Center of Dermatology, Venereology and Cosmetology of The Russian Ministry of Health (SRCDVC) Moscow Russia"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895545158790","@type":"Researcher","foaf:name":[{"@value":"Alexey Kubanov"}],"jpcoar:affiliationName":[{"@value":"The State Research Center of Dermatology, Venereology and Cosmetology of The Russian Ministry of Health (SRCDVC) Moscow Russia"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895545158789","@type":"Researcher","foaf:name":[{"@value":"Magnus Unemo"}],"jpcoar:affiliationName":[{"@value":"WHO Collaborating Centre for Gonorrhoea and Other STIs National Reference Laboratory for Pathogenic Neisseria Department of Laboratory Medicine, Microbiology Faculty of Medicine and Health Örebro University Örebro Sweden"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09034641"},{"@type":"EISSN","@value":"16000463"}],"prism:publicationName":[{"@value":"APMIS"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2016-04-22","prism:volume":"124","prism:number":"7","prism:startingPage":"595","prism:endingPage":"602"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fapm.12541"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/apm.12541"}],"createdAt":"2016-04-22","modifiedAt":"2023-09-26","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004235982845056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Circulation of Distinct\n            <i>Treponema pallidum</i>\n            Strains in Individuals with Heterosexual Orientation and Men Who Have Sex with Men"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142799703040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Epidemiology, molecular strain types, and macrolide resistance of Treponema pallidum in Japan, 2017–2018"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710959560960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Molecular Typing and Macrolide Resistance Analyses of Treponema pallidum in Heterosexuals and Men Who Have Sex with Men in Japan, 2017"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/apm.12541"},{"@type":"CROSSREF","@value":"10.1128/jcm.01148-18_references_DOI_ZoTyp99qHfupiQI0fyJyDZzzpnc"},{"@type":"CROSSREF","@value":"10.1016/j.jiac.2020.05.022_references_DOI_ZoTyp99qHfupiQI0fyJyDZzzpnc"},{"@type":"CROSSREF","@value":"10.1128/jcm.01167-18_references_DOI_ZoTyp99qHfupiQI0fyJyDZzzpnc"}]}