{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895690701440.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.neuroscience.2017.03.047"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0306452217302221?httpAccept=text/plain"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0306452217302221?httpAccept=text/xml"}},{"identifier":{"@type":"PMID","@value":"28389378"}}],"dc:title":[{"@value":"Sympathetic regulation and anterior cingulate cortex volume are altered in a rat model of chronic back pain"}],"description":[{"notation":[{"@value":"Chronic pain is associated with autonomic disturbance. However, specific effects of chronic back pain on sympathetic regulation remain unknown. Chronic pain is also associated with structural changes in the anterior cingulate cortex (ACC), which may be linked to sympathetic dysregulation. The aim of this study was to determine whether sympathetic regulation and ACC surface and volume are affected in a rat model of chronic back pain, in which complete Freund Adjuvant (CFA) is injected in back muscles. Sympathetic regulation was assessed with renal blood flow (RBF) changes induced by electrical stimulation of a hind paw, while ACC structure was examined by measuring cortical surface and volume. RBF changes and ACC volume were compared between control rats and rats injected with CFA in back muscles segmental (T10) to renal sympathetic innervation or not (T2). In rats with CFA, chronic inflammation was observed in the affected muscles in addition to increased nuclear factor-kappa B (NF-kB) protein expression in corresponding spinal cord segments (p=0.01) as well as decreased ACC volume (p0.05). In addition, intensity-dependent decreases in RBF during hind paw stimulation were attenuated by chronic pain at T2 (p's0.05) and T10 (p's0.05), but less so at T10 compared with T2 (p's0.05). These results indicate that chronic back pain alters sympathetic functions through non-segmental mechanisms, possibly by altering descending regulatory pathways from ACC. Yet, segmental somato-sympathetic reflexes may compete with non-segmental processes depending on the back region affected by pain and according to the segmental organization of the sympathetic nervous system."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825895690701441","@type":"Researcher","foaf:name":[{"@value":"Sara Touj"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895690701440","@type":"Researcher","foaf:name":[{"@value":"Sébastien Houle"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895690701444","@type":"Researcher","foaf:name":[{"@value":"Djamel Ramla"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895690701443","@type":"Researcher","foaf:name":[{"@value":"Renaud Jeffrey-Gauthier"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895690701446","@type":"Researcher","foaf:name":[{"@value":"Harumi Hotta"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895690701447","@type":"Researcher","foaf:name":[{"@value":"Gilles Bronchti"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895690701445","@type":"Researcher","foaf:name":[{"@value":"Maria-Grazia Martinoli"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895690701442","@type":"Researcher","foaf:name":[{"@value":"Mathieu Piché"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03064522"}],"prism:publicationName":[{"@value":"Neuroscience"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2017-06","prism:volume":"352","prism:startingPage":"9","prism:endingPage":"18"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0306452217302221?httpAccept=text/plain"},{"@id":"https://api.elsevier.com/content/article/PII:S0306452217302221?httpAccept=text/xml"}],"createdAt":"2017-04-04","modifiedAt":"2022-07-27","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Freund's%20Adjuvant","dc:title":"Freund's Adjuvant"},{"@id":"https://cir.nii.ac.jp/all?q=Blood%20Pressure","dc:title":"Blood Pressure"},{"@id":"https://cir.nii.ac.jp/all?q=Gyrus%20Cinguli","dc:title":"Gyrus Cinguli"},{"@id":"https://cir.nii.ac.jp/all?q=Renal%20Circulation","dc:title":"Renal Circulation"},{"@id":"https://cir.nii.ac.jp/all?q=Adjuvants,%20Immunologic","dc:title":"Adjuvants, Immunologic"},{"@id":"https://cir.nii.ac.jp/all?q=Laser-Doppler%20Flowmetry","dc:title":"Laser-Doppler Flowmetry"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Wistar","dc:title":"Rats, Wistar"},{"@id":"https://cir.nii.ac.jp/all?q=Myositis","dc:title":"Myositis"},{"@id":"https://cir.nii.ac.jp/all?q=Back%20Muscles","dc:title":"Back Muscles"},{"@id":"https://cir.nii.ac.jp/all?q=NF-kappa%20B","dc:title":"NF-kappa B"},{"@id":"https://cir.nii.ac.jp/all?q=Membrane%20Proteins","dc:title":"Membrane Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Electric%20Stimulation","dc:title":"Electric Stimulation"},{"@id":"https://cir.nii.ac.jp/all?q=Hindlimb","dc:title":"Hindlimb"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Autonomic%20Nervous%20System%20Diseases","dc:title":"Autonomic Nervous System Diseases"},{"@id":"https://cir.nii.ac.jp/all?q=Spinal%20Cord","dc:title":"Spinal Cord"},{"@id":"https://cir.nii.ac.jp/all?q=Back%20Pain","dc:title":"Back Pain"},{"@id":"https://cir.nii.ac.jp/all?q=Cyclooxygenase%201","dc:title":"Cyclooxygenase 1"},{"@id":"https://cir.nii.ac.jp/all?q=Chronic%20Pain","dc:title":"Chronic Pain"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360572092821938304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Short-term infusion of ultralow-dose dopamine in an adult horse with acute kidney injury: A case report"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118805923840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Attenuation of widespread hypersensitivity to noxious mechanical stimuli by inhibition of GABAergic neurons of the right amygdala in a rat model of chronic back pain"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.neuroscience.2017.03.047"},{"@type":"OPENAIRE","@value":"doi_dedup___::ffc6813f44cba556dcfa846d9f8536ff"},{"@type":"CROSSREF","@value":"10.1016/j.vas.2021.100176_references_DOI_8u1uwAqyESY2FaNJXB2Xrzj7VgN"},{"@type":"CROSSREF","@value":"10.1002/ejp.1921_references_DOI_8u1uwAqyESY2FaNJXB2Xrzj7VgN"}]}