{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895716359808.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1152/ajpcell.2000.278.1.c174"}},{"identifier":{"@type":"URI","@value":"https://journals.physiology.org/doi/pdf/10.1152/ajpcell.2000.278.1.C174"}}],"dc:title":[{"@value":"Hepatocyte growth factor affects satellite cell activation  and differentiation in regenerating skeletal muscle"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p> Hepatocyte growth factor (HGF) is the only known growth factor that activates quiescent satellite cells in skeletal muscle. We hypothesized that local delivery of HGF may enhance regeneration after trauma by increasing the number of myoblasts available for restoring normal tissue architecture. Injection of HGF into muscle at the time of injury increases myoblast number but does not enhance tissue repair as determined using quantitative histological analyses. Rather, depending on the dose and the timing of HGF administration relative to the injury, regeneration can be inhibited. The greatest inhibitory effect is observed when HGF is administered on the day of injury and continued for 3 days, corresponding to the time when satellite cell activation, proliferation, and early differentiation normally occur. To establish a mechanism for this inhibition, we show that HGF can act directly on primary muscle cells to block differentiation. These results demonstrate that 1) exogenous HGF synergizes with factors in damaged muscle to increase myoblast number, 2) regeneration is not regulated solely by myoblast number, and 3) HGF inhibits muscle differentiation both in vitro and in vivo. </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825895716359680","@type":"Researcher","foaf:name":[{"@value":"Kristy J. Miller"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895716359810","@type":"Researcher","foaf:name":[{"@value":"Deepa Thaloor"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895716359809","@type":"Researcher","foaf:name":[{"@value":"Sarah Matteson"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895716359808","@type":"Researcher","foaf:name":[{"@value":"Grace K. Pavlath"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"03636143"},{"@type":"EISSN","@value":"15221563"}],"prism:publicationName":[{"@value":"American Journal of Physiology-Cell Physiology"}],"dc:publisher":[{"@value":"American Physiological Society"}],"prism:publicationDate":"2000-01-01","prism:volume":"278","prism:number":"1","prism:startingPage":"C174","prism:endingPage":"C181"},"reviewed":"false","url":[{"@id":"https://journals.physiology.org/doi/pdf/10.1152/ajpcell.2000.278.1.C174"}],"createdAt":"2017-12-24","modifiedAt":"2024-06-17","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004231544092800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A comparative study of myostatin, follistatin and decorin expression in muscle of different origin"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306905626154240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Macrophage Subpopulation Promotes Skeletal Muscle Regeneration Through <scp>HGF</scp>/<scp>MET</scp> Signaling‐Mediated Skeletal Muscle Stem Cell Proliferation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092749420160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Aging of the immune system and impaired muscle regeneration: A failure of immunomodulation of adult myogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656931604352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Overexpression of hepatocyte growth factor in SBMA model mice has an additive effect on combination therapy with castration"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848664406481024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"HGF–Met Pathway in Regeneration and Drug Discovery"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679435339392","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"HGF and IGF-1 is Present during the Developmental Process of Murine Masseter Muscle"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680392733440","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Recent research developments in regeneration of skeletal muscle"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680393035392","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mechanism of satellite cell regulation by myokines"}]},{"@id":"https://cir.nii.ac.jp/crid/1390291767944615680","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Elevated level of microRNA-210 at the initiation of muscular regeneration in          acetic acid-induced non-ischemic skeletal muscular injury in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1391130851444967680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mesenchymal Stem Cells Alter the Inflammatory Response of C2C12 Mouse Skeletal Muscle Cells"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1152/ajpcell.2000.278.1.c174"},{"@type":"CROSSREF","@value":"10.1007/s12565-011-0103-0_references_DOI_DnJxCTWLZcmnOYuhowhPF8obKVx"},{"@type":"CROSSREF","@value":"10.7600/jpfsm.6.311_references_DOI_DnJxCTWLZcmnOYuhowhPF8obKVx"},{"@type":"CROSSREF","@value":"10.2485/jhtb.18.1_references_DOI_DnJxCTWLZcmnOYuhowhPF8obKVx"},{"@type":"CROSSREF","@value":"10.1293/tox.2021-0061_references_DOI_DnJxCTWLZcmnOYuhowhPF8obKVx"},{"@type":"CROSSREF","@value":"10.1111/acel.70042_references_DOI_DnJxCTWLZcmnOYuhowhPF8obKVx"},{"@type":"CROSSREF","@value":"10.1016/j.exger.2020.111200_references_DOI_DnJxCTWLZcmnOYuhowhPF8obKVx"},{"@type":"CROSSREF","@value":"10.3390/biomedicines2040275_references_DOI_DnJxCTWLZcmnOYuhowhPF8obKVx"},{"@type":"CROSSREF","@value":"10.1248/bpb.b20-00536_references_DOI_DnJxCTWLZcmnOYuhowhPF8obKVx"},{"@type":"CROSSREF","@value":"10.7600/jpfsm.1.401_references_DOI_DnJxCTWLZcmnOYuhowhPF8obKVx"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2015.11.015_references_DOI_DnJxCTWLZcmnOYuhowhPF8obKVx"}]}