{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895733009792.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/embo-reports/kvf007"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1093%2Fembo-reports%2Fkvf007"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1093/embo-reports/kvf007"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1093/embo-reports/kvf007"}},{"identifier":{"@type":"URI","@value":"https://www.embopress.org/doi/pdf/10.1093/embo-reports/kvf007"}}],"dc:title":[{"@value":"The processivity factor β controls DNA polymerase IV traffic during spontaneous mutagenesis and translesion synthesis\n in vivo"}],"description":[{"type":"abstract","notation":[{"@value":"\n The\n dinB\n ‐encoded DNA polymerase IV (Pol IV) belongs to the recently identified Y‐family of DNA polymerases. Like other members of this family, Pol IV is involved in translesion synthesis and mutagenesis. Here, we show that the C‐terminal five amino acids of Pol IV are essential in targeting it to the β‐clamp, the processivity factor of the replicative DNA polymerase (Pol III) of\n Escherichia coli\n .\n In vivo\n , the disruption of this interaction obliterates the function of Pol IV in both spontaneous and induced mutagenesis. These results point to the pivotal role of the processivity clamp during DNA polymerase trafficking in the vicinity of damaged‐template DNA.\n "}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825895733009793","@type":"Researcher","foaf:name":[{"@value":"Nathalie Lenne‐Samuel"}],"jpcoar:affiliationName":[{"@value":"Institut de Recherche contre les Cancers de l'Appareil Digestif, Unité Propre de Recherche 9003 du Centre National de la Recherche Scientifique, UPR conventionnée de l'Université Louis Pasteur de Strasbourg, Hôpitaux Universitaires BP424 67091 Strasbourg France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895733009795","@type":"Researcher","foaf:name":[{"@value":"Jérôme Wagner"}],"jpcoar:affiliationName":[{"@value":"Institut de Recherche contre les Cancers de l'Appareil Digestif, Unité Propre de Recherche 9003 du Centre National de la Recherche Scientifique, UPR conventionnée de l'Université Louis Pasteur de Strasbourg, Hôpitaux Universitaires BP424 67091 Strasbourg France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895733009794","@type":"Researcher","foaf:name":[{"@value":"Hélène Etienne"}],"jpcoar:affiliationName":[{"@value":"Institut de Recherche contre les Cancers de l'Appareil Digestif, Unité Propre de Recherche 9003 du Centre National de la Recherche Scientifique, UPR conventionnée de l'Université Louis Pasteur de Strasbourg, Hôpitaux Universitaires BP424 67091 Strasbourg France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895733009792","@type":"Researcher","foaf:name":[{"@value":"Robert P P Fuchs"}],"jpcoar:affiliationName":[{"@value":"Institut de Recherche contre les Cancers de l'Appareil Digestif, Unité Propre de Recherche 9003 du Centre National de la Recherche Scientifique, UPR conventionnée de l'Université Louis Pasteur de Strasbourg, Hôpitaux Universitaires BP424 67091 Strasbourg France"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1469221X"},{"@type":"EISSN","@value":"14693178"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/1469221X"}],"prism:publicationName":[{"@value":"EMBO reports"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2002-01","prism:volume":"3","prism:number":"1","prism:startingPage":"45","prism:endingPage":"49"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1093%2Fembo-reports%2Fkvf007"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1093/embo-reports/kvf007"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1093/embo-reports/kvf007"},{"@id":"https://www.embopress.org/doi/pdf/10.1093/embo-reports/kvf007"}],"createdAt":"2002-07-26","modifiedAt":"2025-12-06","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360567184623479424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Interaction between Escherichia coli DNA polymerase IV and single-stranded DNA-binding protein is required for DNA synthesis on SSB-coated DNA"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658411537152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Collision with duplex DNA renders Escherichia coli DNA polymerase III holoenzyme susceptible to DNA polymerase IV-mediated polymerase switching on the sliding clamp"}]},{"@id":"https://cir.nii.ac.jp/crid/2050870367073278336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effect of episomally encoded DNA polymerases on chemically induced mutagenesis at the hisG46 target in Ames test"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1093/embo-reports/kvf007"},{"@type":"CROSSREF","@value":"10.1093/nar/gks264_references_DOI_3cB4NOGERNfq1ElWvBMAbeJ5tnN"},{"@type":"CROSSREF","@value":"10.1038/s41598-017-13080-1_references_DOI_3cB4NOGERNfq1ElWvBMAbeJ5tnN"},{"@type":"CROSSREF","@value":"10.1186/s41021-020-00154-2_references_DOI_3cB4NOGERNfq1ElWvBMAbeJ5tnN"}]}