{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895758558976.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.4049/jimmunol.170.9.4432"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/jimmunol/article-pdf/170/9/4432/62565422/4432.pdf"}}],"dc:title":[{"@value":"Cutting Edge: Roles of Toll-Like Receptor 4 and IL-23 in IL-17 Expression in Response to\n                    <i>Klebsiella pneumoniae</i>\n                    Infection"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>Local production of IL-17 is a significant factor in effective host defense against Gram-negative bacteria. However, the proximal events mediating IL-17 elaboration by T cells remain unclear. In this study, we show in vivo that intact Toll-like receptor 4 signaling in the lung is required for induction of both the p19 transcript of IL-23 and IL-17 protein elaboration in response to Klebsiella pneumoniae. Although IL-17 is widely considered a CD4+ T cell product, we also demonstrate significant in vitro IL-17 production by CD8+ T cells after culture in medium from dendritic cells exposed to these bacteria. The dominant portion of this IL-17-inducing activity for both CD4+ and CD8+ T cells is IL-23. These data demonstrate the critical signaling pathway for IL-17 induction in the host response to Gram-negative pulmonary infection and suggest a direct role for IL-23 in CD8+ T cell IL-17 production.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380589016249788677","@type":"Researcher","foaf:name":[{"@value":"Kyle I Happel"}],"jpcoar:affiliationName":[{"@value":"Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Science Center , New Orleans, LA 70112"},{"@value":"Alcohol Research Center, Louisiana State University Health Science Center , New Orleans, LA 70112"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895758558984","@type":"Researcher","foaf:name":[{"@value":"Mingquan Zheng"}],"jpcoar:affiliationName":[{"@value":"Gene Therapy Program, Louisiana State University Health Science Center , New Orleans, LA 70112"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895758558849","@type":"Researcher","foaf:name":[{"@value":"Erana Young"}],"jpcoar:affiliationName":[{"@value":"Gene Therapy Program, Louisiana State University Health Science Center , New Orleans, LA 70112"}]},{"@id":"https://cir.nii.ac.jp/crid/1380589016249788678","@type":"Researcher","foaf:name":[{"@value":"Lee J Quinton"}],"jpcoar:affiliationName":[{"@value":"Alcohol Research Center, Louisiana State University Health Science Center , New Orleans, LA 70112"},{"@value":"Department of Physiology, Louisiana State University Health Science Center , New Orleans, LA 70112"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895758558979","@type":"Researcher","foaf:name":[{"@value":"Euan Lockhart"}],"jpcoar:affiliationName":[{"@value":"Gene Therapy Program, Louisiana State University Health Science Center , New Orleans, LA 70112"}]},{"@id":"https://cir.nii.ac.jp/crid/1380589016249788675","@type":"Researcher","foaf:name":[{"@value":"Alistair J Ramsay"}],"jpcoar:affiliationName":[{"@value":"Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Science Center , New Orleans, LA 70112"},{"@value":"Gene Therapy Program, Louisiana State University Health Science Center , New Orleans, LA 70112"}]},{"@id":"https://cir.nii.ac.jp/crid/1380589016249788674","@type":"Researcher","foaf:name":[{"@value":"Judd E Shellito"}],"jpcoar:affiliationName":[{"@value":"Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Science Center , New Orleans, LA 70112"},{"@value":"Alcohol Research Center, Louisiana State University Health Science Center , New Orleans, LA 70112"},{"@value":"Gene Therapy Program, Louisiana State University Health Science Center , New Orleans, LA 70112"}]},{"@id":"https://cir.nii.ac.jp/crid/1380589016249788676","@type":"Researcher","foaf:name":[{"@value":"Jill R Schurr"}],"jpcoar:affiliationName":[{"@value":"Gene Therapy Program, Louisiana State University Health Science Center , New Orleans, LA 70112"}]},{"@id":"https://cir.nii.ac.jp/crid/1380589016249788673","@type":"Researcher","foaf:name":[{"@value":"Gregory J Bagby"}],"jpcoar:affiliationName":[{"@value":"Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Science Center , New Orleans, LA 70112"},{"@value":"Alcohol Research Center, Louisiana State University Health Science Center , New Orleans, LA 70112"},{"@value":"Department of Physiology, Louisiana State University Health Science Center , New Orleans, LA 70112"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895758558983","@type":"Researcher","foaf:name":[{"@value":"Steve Nelson"}],"jpcoar:affiliationName":[{"@value":"Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Science Center , New Orleans, LA 70112"},{"@value":"Alcohol Research Center, Louisiana State University Health Science Center , New Orleans, LA 70112"},{"@value":"Department of Physiology, Louisiana State University Health Science Center , New Orleans, LA 70112"}]},{"@id":"https://cir.nii.ac.jp/crid/1380589016249788672","@type":"Researcher","foaf:name":[{"@value":"Jay K Kolls"}],"jpcoar:affiliationName":[{"@value":"Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Science Center , New Orleans, LA 70112"},{"@value":"Alcohol Research Center, Louisiana State University Health Science Center , New Orleans, LA 70112"},{"@value":"Gene Therapy Program, Louisiana State University Health Science Center , New Orleans, LA 70112"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00221767"},{"@type":"EISSN","@value":"15506606"}],"prism:publicationName":[{"@value":"The Journal of Immunology"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2003-05-01","prism:volume":"170","prism:number":"9","prism:startingPage":"4432","prism:endingPage":"4436"},"reviewed":"false","dc:rights":["https://academic.oup.com/pages/standard-publication-reuse-rights"],"url":[{"@id":"https://academic.oup.com/jimmunol/article-pdf/170/9/4432/62565422/4432.pdf"}],"createdAt":"2014-04-20","modifiedAt":"2026-02-02","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004234610838144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Two Types of Interleukin 17A–Producing γδ T Cells in Protection Against Pulmonary Infection With<i>Klebsiella pneumoniae</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693097122304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Interleukin‐17 family cytokines in protective immunity against infections: role of hematopoietic cell‐derived and non‐hematopoietic cell‐derived interleukin‐17s"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283695889153536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Complement C3a-Induced IL-17 Plays a Critical Role in an IgE-Mediated Late-Phase Asthmatic Response and Airway Hyperresponsiveness via Neutrophilic Inflammation in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708405146624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in 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