{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895776671872.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.1128294"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.1128294"}},{"identifier":{"@type":"NAID","@value":"80018956737"}}],"dc:title":[{"@value":"Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Endoplasmic reticulum (ER) stress is a key link between obesity, insulin resistance, and type 2 diabetes. Here, we provide evidence that this mechanistic link can be exploited for therapeutic purposes with orally active chemical chaperones. 4-Phenyl butyric acid and taurine-conjugated ursodeoxycholic acid alleviated ER stress in cells and whole animals. Treatment of obese and diabetic mice with these compounds resulted in normalization of hyperglycemia, restoration of systemic insulin sensitivity, resolution of fatty liver disease, and enhancement of insulin action in liver, muscle, and adipose tissues. Our results demonstrate that chemical chaperones enhance the adaptive capacity of the ER and act as potent antidiabetic modalities with potential application in the treatment of type 2 diabetes.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825895776671747","@type":"Researcher","foaf:name":[{"@value":"Umut Özcan"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics and Complex Diseases, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895776671744","@type":"Researcher","foaf:name":[{"@value":"Erkan Yilmaz"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics and Complex Diseases, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895776671748","@type":"Researcher","foaf:name":[{"@value":"Lale Özcan"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics and Complex Diseases, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895776671745","@type":"Researcher","foaf:name":[{"@value":"Masato Furuhashi"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics and Complex Diseases, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895776671873","@type":"Researcher","foaf:name":[{"@value":"Eric Vaillancourt"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics and Complex Diseases, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895776671749","@type":"Researcher","foaf:name":[{"@value":"Ross O. Smith"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics and Complex Diseases, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895776671872","@type":"Researcher","foaf:name":[{"@value":"Cem Z. Görgün"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics and Complex Diseases, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895776671746","@type":"Researcher","foaf:name":[{"@value":"Gökhan S. Hotamisligil"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics and Complex Diseases, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"2006-08-25","prism:volume":"313","prism:number":"5790","prism:startingPage":"1137","prism:endingPage":"1140"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/science.1128294"}],"createdAt":"2006-08-24","modifiedAt":"2024-01-09","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050002212669077376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"Protective role of podocyte autophagy against glomerular endothelial dysfunction in diabetes."}]},{"@id":"https://cir.nii.ac.jp/crid/1050304183897116288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity"}]},{"@id":"https://cir.nii.ac.jp/crid/1050564288162604672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endoplasmic Reticulum Stress Impaired Uncoupling Protein 1 Expression via the Suppression of Peroxisome Proliferator-Activated Receptor γ Binding Activity in Mice Beige Adipocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1050577309352787584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"4-Phenylbutyrate suppresses the unfolded protein response without restoring protein folding in Saccharomyces cerevisiae"}]},{"@id":"https://cir.nii.ac.jp/crid/1050585658872712704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells"},{"@value":"Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic ? cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1050845760768533632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity"}]},{"@id":"https://cir.nii.ac.jp/crid/1050856995323512448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1050870451798715136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Ursodeoxycholic acid potentiates dipeptidyl peptidase-4 inhibitor sitagliptin by enhancing glucagon-like peptide-1 secretion in patients with type 2 diabetes and chronic liver disease: a pilot randomized controlled and add-on study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002215850280960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216808345216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002218729628160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Chemical Endoplasmic Reticulum Chaperone Alleviates Doxorubicin-Induced Cardiac Dysfunction"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002219449586816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Late-Onset of Spinal Neurodegeneration in Knock-In Mice Expressing a Mutant BiP"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002220326066048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Proteasome Dysfunction Mediates Obesity-Induced Endoplasmic Reticulum Stress and Insulin Resistance in the Liver"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002220647448192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231330300160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The oxidative stress: endoplasmic reticulum stress axis in cadmium toxicity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232016968704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evaluation of synthetic naphthalene derivatives as novel chemical chaperones that mimic 4-phenylbutyric acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004232428552576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The exacerbating roles of CCAAT/enhancer-binding protein homologous protein (CHOP) in the development of bleomycin-induced pulmonary fibrosis and the preventive effects of tauroursodeoxycholic acid (TUDCA) against pulmonary fibrosis in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233977690752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hepatic Nuclear Factor 1α (HNF1α) Dysfunction Down-regulates X-box-binding Protein 1 (XBP1) and Sensitizes β-Cells to Endoplasmic Reticulum Stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004234483136000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Diabetes and Age-Related Differences in Vascular Function of Renal Artery: Possible Involvement of Endoplasmic Reticulum Stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239454885504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Role of BiP Retrieval by the KDEL Receptor in the Early Secretory Pathway and its Effect on Protein Quality Control and Neurodegeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168784664448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Endocrine Fibroblast Growth Factors in Relation to Stress Signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013168828443648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tauroursodeoxycholic Acid Attenuates Diet-Induced and Age-Related Peripheral Endoplasmic Reticulum Stress and Cerebral Amyloid Pathology in a Mouse Model of Alzheimer's Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360013187676406784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Plasma Tsukushi Concentration Is Associated with High Levels of Insulin and FGF21 and Low Level of Total Cholesterol in a General Population without Medication"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017280671904000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Roles of endoplasmic reticulum stress in the pathophysiology of polycystic ovary syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360022306715517184","@type":"Article","resourceType":"preprint","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mevalonate pathway-mediated ER homeostasis is required for haploid stability in human somatic cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025430638636288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Urinary fatty acid‐binding protein 4 is a promising biomarker for glomerular damage in patients with diabetes mellitus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360282588996367872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Expression of Vascular Endothelial Growth Factor by Retinal Pigment Epithelial Cells Induced by Amyloid-β Is Depressed by an Endoplasmic Reticulum Stress Inhibitor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283689648351872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tauroursodeoxycholic Acid, a Bile Acid, Promotes Blood Vessel Repair by Recruiting Vasculogenic Progenitor Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690799587968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Potent inhibitors of amyloid β fibrillization, 4,5-dianilinophthalimide and staurosporine aglycone, enhance degradation of preformed aggregates of mutant Notch3"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691151037056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"From zero to six double bonds: phospholipid unsaturation and organelle function"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691176576640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Disruption of the mitochondria-associated ER membrane (MAM) plays a central role in palmitic acid–induced insulin resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692255535232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>Fibroblast growth factor 21</i> induction by activating transcription factor 4 is regulated through three amino acid response elements in its promoter region"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692468305664","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692563449472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Emerging issues in radiogenic cataracts and cardiovascular disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693782978816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R–mediated apoptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283694052946048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Effect of Endoplasmic Reticulum Stress on Neurotoxicity Caused by Inhaled Anesthetics"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283695302820352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Activating Transcription Factor 4 Links Metabolic Stress to Interleukin-6 Expression in Macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283695651254528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Signaling Pathways from the Endoplasmic Reticulum and Their Roles in Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283695654533760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Endoplasmic Reticulum (ER) Stress and Endocrine Disorders"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706993534208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707242832896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Unfolded protein response in keratinocytes: Impact on normal and abnormal keratinization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707277873024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Targeting the enhanced ER stress response in Marinesco-Sjögren syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707339170432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A potential role of endoplasmic reticulum stress in development of ovarian hyperstimulation syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708406749056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708427910400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Proteostasis in endoplasmic reticulum—new mechanisms in kidney disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708445141376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711697708416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Attenuation of endoplasmic reticulum stress in Pelizaeus-Merzbacher disease by an anti-malaria drug, chloroquine"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711724225152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Regulation of extracellular-superoxide dismutase in rat retina pericytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711956248320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285712480814208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role of ER Stress in Ventricular Contractile Dysfunction in Type 2 Diabetes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617418235904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Inhibition of the PI 3‐kinase pathway disrupts the unfolded protein response and reduces sensitivity to ER stress‐dependent apoptosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617792452992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pharmacological Chaperones Attenuate the Development of Opioid Tolerance"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643842822912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Free Deoxycholic Acid Exacerbates Vascular Calcification in CKD through ER Stress-Mediated ATF4 Activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294808393041664","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification of Novel Oxindole Compounds That Suppress ER Stress-Induced Cell Death as Chemical Chaperones"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298754813981184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"PAC1 Deficiency Protects Obese Male Mice From Immobilization-Induced Muscle Atrophy by Suppressing FoxO–Atrogene Axis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757193448192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>Chlamydia pneumoniae</i> Lung Infection in Mice Induces Fatty Acid–Binding Protein 4–Dependent White Adipose Tissue Pathology"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757452547200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Epstein–Barr virus-induced gene 3 commits human mesenchymal stem cells to differentiate into chondrocytes via endoplasmic reticulum stress sensor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165216937600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165776417536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Endoplasmic reticulum stress enhances γ-secretase activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168115329664","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Membrane lipid saturation activates <scp>IRE</scp>1α without inducing clustering"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168296672256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Endoplasmic reticulum stress response and bone loss in experimental periodontitis in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565170279488896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Brown Rice and Its Component, γ-Oryzanol, Attenuate the Preference for High-Fat Diet by Decreasing Hypothalamic Endoplasmic Reticulum Stress in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567179932812288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Endoplasmic Reticulum (ER)‐Targeted, Galectin‐Mediated Retrograde Transport by Using a HaloTag Carrier Protein"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181213690368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lipid overloading during liver regeneration causes delayed hepatocyte DNA replication by increasing ER stress in mice with simple hepatic steatosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181214187136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181889210624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Contribution of p38 MAPK, NF-κB and glucocorticoid signaling pathways to ER stress-induced increase in retinal endothelial permeability"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181953549696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Caloric restriction decreases ER stress in liver and adipose tissue in ob/ob mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182020349440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Adipocyte-Inducible Secreted Phospholipases PLA2G5 and PLA2G2E Play Distinct Roles in Obesity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182345857280","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Chemical chaperone 4-phenylbutylate reduces mutant protein accumulation in the endoplasmic reticulum of arginine vasopressin neurons in a mouse model for familial neurohypophysial diabetes insipidus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182381963264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183392382720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The other sweet face of XBP-1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183484942976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Undernourishment in utero Primes Hepatic Steatosis in Adult Mice Offspring on an Obesogenic Diet; Involvement of Endoplasmic Reticulum Stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183491225856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Histone Deacetylase Inhibitor Phenylbutyrate Exaggerates Heart Failure in Pressure Overloaded Mice independently of HDAC inhibition"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186273392768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impact of hepatic HSP72 on insulin signaling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186276565632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Reduction of endoplasmic reticulum stress by 4-phenylbutyric acid prevents the development of hypoxia-induced pulmonary arterial hypertension"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186296849792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Endoplasmic Reticulum Stress and Parkinson’s Disease: The Role of HRD1 in Averting Apoptosis in Neurodegenerative Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186649641856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Sodium 4-Phenylbutyrate Attenuates Myocardial Reperfusion Injury by Reducing the Unfolded Protein Response"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189165880960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Endoplasmic reticulum stress induces retinal endothelial permeability of extracellular-superoxide dismutase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092475219584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pathological Aspects of COVID-19 as a Conformational Disease and the Use of Pharmacological Chaperones as a Potential Therapeutic Strategy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118742985856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Leptin sensitizing effect of 1,3-butanediol and its potential mechanism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640222147968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The role of the unfolded protein response in diabetes mellitus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640783495168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641098750464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Bile Acids Protect Expanding Hematopoietic Stem Cells from Unfolded Protein Stress in Fetal Liver"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641101071616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Biliopancreatic limb plays an important role in metabolic improvement after duodenal–jejunal bypass in a rat model of diabetes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643588142592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Endoplasmic reticulum stress and unfolded protein response in renal pathophysiology: Janus faces"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656930852224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Sodium tauroursodeoxycholate prevents paraquat-induced cell death by suppressing endoplasmic reticulum stress responses in human lung epithelial A549 cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657328520704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Orexin neurons in hypothalamic slice cultures are vulnerable to endoplasmic reticulum stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658343875968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658470848896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Novel Treatment of Chronic Graft-Versus-Host Disease in Mice Using the ER Stress Reducer 4-Phenylbutyric Acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658907377920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Peptidyl-prolyl Cis/Trans Isomerase NIMA-interacting 1 Associates with Insulin Receptor Substrate-1 and Enhances Insulin Actions and Adipogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660704585472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Endoplasmic reticulum stress induced by tunicamycin increases resistin messenger ribonucleic acid through the pancreatic endoplasmic reticulum eukaryotic initiation factor 2α kinase–activating transcription factor 4–CAAT/enhancer binding protein‐α homologous protein pathway in THP‐1 human monocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848663849364096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Endoplasmic Reticulum Stress Inhibits STAT3-Dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593790976896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"CD244 expression represents functional decline of murine hematopoietic stem cells after in vitro culture"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861705573908480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Glomerular expression and urinary excretion of fatty acid-binding protein 4 in IgA nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707376607104","@type":"Article","resourceType":"preprint","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707381236736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effects of Epigenetic Modification of PGC-1α by a Chemical Chaperon on Mitochondria Biogenesis and Visual Function in Retinitis Pigmentosa"}]},{"@id":"https://cir.nii.ac.jp/crid/1361412892206244352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role of endoplasmic reticulum stress on developmental competency and cryo-tolerance in bovine embryos"}]},{"@id":"https://cir.nii.ac.jp/crid/1361975843213659776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670319099127552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Role of C-mannosylation in the secretion of mindin"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204367387520","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The Role of Zinc and ER Stress in the Pathogenesis of Amyotrophic Lateral Sclerosis"},{"@language":"ja","@value":"筋萎縮性側索硬化症における亜鉛と小胞体ストレスの役割"},{"@language":"ja-Kana","@value":"キン イシュクセイ ソクサク コウカショウ ニ オケル アエン ト ショウホウタイ ストレス ノ ヤクワリ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204632731136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Factor for Adipocyte Differentiation 158 Gene Disruption Prevents the Body Weight Gain and Insulin Resistance Induced by a High-Fat Diet"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204906683008","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"小胞体ストレスとインスリン抵抗性"},{"@language":"en","@value":"ER Stress and Insulin Resistance"},{"@language":"ja-Kana","@value":"ショウホウタイ ストレス ト インスリン テイコウセイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205044995072","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Aortic ER Stress in Streptozotocin-Induced Diabetes Mellitus in APA Hamsters"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205180895232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer’s Disease:<BR>Endoplasmic Reticulum Stress and Immunological Stress in Pathogenesis of Alzheimer’s Disease"},{"@value":"Endoplasmic Reticulum Stress and Immunological Stress in Pathogenesis of Alzheimer's Disease"},{"@value":"Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer’s Disease: Endoplasmic Reticulum Stress and Immunological Stress in Pathogenesis of Alzheimer’s Disease"},{"@value":"Molecular approaches to the treatment, prophylaxis, and diagnosis of Alzheimer׳s disease: endoplasmic reticulum stress and immunological stress in pathogenesis of Alzheimer׳s disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205181325568","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Carnosine Ameliorates Stress-Induced Glucose Metabolism Disorder in Restrained Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205737504128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Tauroursodeoxycholic acid attenuates inorganic phosphate-induced osteoblastic differentiation and mineralization in NIH3T3 fibroblasts by inhibiting the ER stress response PERK-eIF2α-ATF4 pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206128694016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"小胞体ストレス応答機構の分子薬理学的研究：神経変性疾患の予防・治療をめざして"},{"@language":"en","@value":"Molecular Pharmacological Studies on the Protection Mechanism against Endoplasmic Reticulum Stress-induced Neurodegenerative Disease"},{"@language":"ja-Kana","@value":"ショウホウタイ ストレス オウトウ キコウ ノ ブンシ ヤクリガクテキ ケンキュウ : シンケイ ヘンセイ シッカン ノ ヨボウ ・ チリョウ オ メザシテ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206297837440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pioglitazone Reduces ER Stress in the Liver: Direct Monitoring of in vivo ER Stress Using ER Stress-activated Indicator Transgenic Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001288040998400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"FGF21 Alleviates Hepatic Endoplasmic Reticulum Stress under Physiological Conditions"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679154255232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Hydroxynaphthoic Acids Identified in a High Throughput Screening Potently Ameliorate Endoplasmic Reticulum Stress as Novel Chemical Chaperones"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679252036608","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Bile acids and their pathophysiological role in metabolic disorders"},{"@language":"ja","@value":"胆汁酸からの糖・脂質代謝疾患への新たなアプローチ"},{"@language":"ja-Kana","@value":"タンジュウサン カラ ノ トウ シシツ タイシャ シッカン エ ノ アラタ ナ アプローチ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679410303360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Acid Sphingomyelinase Mediates Oxidized-LDL Induced Apoptosis in Macrophage <i>via</i> Endoplasmic Reticulum Stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679609169152","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Protective Effects of 4-Phenylbutyrate Derivatives on the Neuronal Cell Death and Endoplasmic Reticulum Stress"},{"@value":"Protective effects of - phenylbutyrate derivatives on the neuronal cell death and endoplasmic reticulum stress"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679648249216","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Dietary combination of sucrose and linoleic acid causes skeletal muscle metabolic abnormalities in Zucker fatty rats through specific modification of fatty acid composition"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680157631488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of the Chemical Chaperone 4-Phenylbutylate on the Function of the Serotonin Transporter (SERT) Expressed in COS-7 Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390302547365109760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Type 1 Diabetes Mellitus with Diabetic Ketoacidosis Presenting with Transient Severe Fatty Liver and Subsequent Liver Dysfunction"},{"@value":"A Case of Type 1 Diabetes Mellitus with Diabetic Ketoacidosis Presenting with Transient Severe Fatty Liver and Subsequent Liver Dysfunction"}]},{"@id":"https://cir.nii.ac.jp/crid/1390564227297990400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Phenylbutyrate Ameliorates High-Fat Diet-Induced Obesity <i>via</i> Brown Adipose Tissue Activation"},{"@value":"Phenylbutyrate Ameliorates High-Fat Diet-Induced Obesity via Brown Adipose Tissue Activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1390564238102879360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Progress in Development of Interventions to Prevent Birth Defects in Diabetic Pregnancies"}]},{"@id":"https://cir.nii.ac.jp/crid/1390568617214548480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mevalonate Pathway-mediated ER Homeostasis Is Required for Haploid Stability in Human Somatic Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390853719881996544","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Undernourishment in utero and hepatic steatosis in later life: A potential issue in Japanese people"},{"@value":"Undernourishment <i>in utero</i> and hepatic steatosis in later life: A potential issue in Japanese people"}]},{"@id":"https://cir.nii.ac.jp/crid/1390858861757780736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"The role of bile acids in regulating glucose and lipid metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1520009407457454976","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"脂肪組織リモデリング"},{"@language":"ja-Kana","@value":"シボウ ソシキ リモデリング"}]},{"@id":"https://cir.nii.ac.jp/crid/1520572359445639808","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"小胞体ストレス(ERストレス)シグナリングの膵臓β細胞における役割"},{"@language":"ja-Kana","@value":"ショウホウタイ ストレス ER ストレス シグナリング ノ スイゾウ ベータ サイボウ ニ オケル ヤクワリ"}]},{"@id":"https://cir.nii.ac.jp/crid/1523669555276769280","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@value":"Recapitulation of genome-wide association studies on pulse pressure and mean arterial pressure in the Korean population"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1126/science.1128294"},{"@type":"CIA","@value":"80018956737"},{"@type":"CROSSREF","@value":"10.1038/nm.3759_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1161/circresaha.115.307604_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0112837_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.3389/fendo.2016.00138_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1007/s10534-010-9296-2_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1038/s41598-018-32575-z_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1074/jbc.m111.247866_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1136/bmjdrc-2017-000469_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.3389/fnmol.2017.00222_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.celrep.2017.12.051_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.neulet.2018.06.013_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1254/jphs.11r09fm_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.bmcl.2013.08.001_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1248/yakushi.12-00249_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.chembiol.2022.01.002_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.3390/cells11030505_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.3390/metabo12030237_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.3389/fendo.2023.1124405_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1101/2020.11.05.369231_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1111/jdi.14388_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1002/stem.1901_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1080/09168451.2015.1135045_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1091/mbc.e11-04-0295_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1093/femsyr/foy016_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1093/jrr/rru036_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1172/jci74056_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.3390/genes4030306_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.3390/ijms18020382_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1038/ncomms4428_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1038/nrneph.2014.67_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1038/s41467-019-08591-6_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1177/1535370213520108_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1179/135100010x12826446921662_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1242/jcs.180505_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1248/bpb.35.84_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0039893_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.2337/db11-1652_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.2337/db13-0757_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1254/jphs.12194fp_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.2337/db10-1684_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1248/bpb.34.1257_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1248/cpb.c13-00251_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.phrs.2014.06.003_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2010.09.105_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1248/cpb.c18-01013_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1096/fj.202000892r_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.3390/ijms21207536_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.34067/kid.0007502020_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1021/acschemneuro.2c00064_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1507/endocrj.ej22-0544_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1210/endocr/bqad065_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.4049/jimmunol.2200601_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0279584_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1007/s00125-014-3475-6_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1111/gtc.12074_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1111/jre.12232_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1002/cbic.201500489_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1007/s00535-013-0780-7_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1007/s00535-014-1033-0_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1038/nm0311-246_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1038/srep16867_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1038/srep34036_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1152/ajpendo.00215.2018_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1152/ajpheart.00869.2013_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1155/2013/239854_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1177/1074248416679308_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1213/ane.0b013e3182a74773_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.3109/10715762.2011.595408_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.3390/ijms20020274_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.5582/ddt.2015.01008_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.surg.2015.11.027_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.jns.2017.12.010_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1538/expanim.58.113_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1254/jphs.11131fp_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.3164/jcbn.14-11_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.3389/fphar.2020.01095_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1038/s41598-021-96460-y_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1159/000440885_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.3488-24_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1007/s00281-013-0369-5_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1152/ajprenal.00050.2008_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1111/cga.12200_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1038/labinvest.2013.112_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1038/srep35983_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1038/srep41939_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1074/jbc.m110.206904_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1111/jdi.12434_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.cmet.2014.05.002_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.yexcr.2017.08.006_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2010.11.120_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1507/endocrj.k09e-140_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1254/fpj.136.265_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1248/bpb.b19-00346_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2020.02.088_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.bbagen.2020.129632_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.isci.2021.103603_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1007/s40620-022-01551-2_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1101/2023.01.27.525605_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.3390/cells11091497_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.14283/jpad.2021.33_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.stem.2016.01.002_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.7554/elife.43302_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.phrs.2015.05.004_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.bmcl.2014.12.080_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.2337/db11-1767_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.neuroscience.2011.06.026_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.jdermsci.2012.12.002_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2011.11.042_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.ccr.2014.07.001_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.mce.2016.03.032_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.theriogenology.2019.09.042_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2013.01.131_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1089/rej.2015.1662_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.tcb.2015.03.004_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1038/s41598-019-52943-7_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.3177/jnsv.64.200_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1016/j.abb.2012.01.014_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.1247/csf.20055_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"},{"@type":"CROSSREF","@value":"10.5551/jat.32383_references_DOI_UXHwSjUqIBtjbbNx9zCkVSPvkbh"}]}