{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895871132544.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/01.hyp.0000151325.83008.b4"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/01.HYP.0000151325.83008.b4"}},{"identifier":{"@type":"NAID","@value":"30022678557"}}],"dc:title":[{"@value":"Obesity-Associated Hypertension"}],"dcterms:alternative":[{"@value":"New Insights Into Mechanisms"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Obesity is strongly associated with hypertension and cardiovascular disease. Several central and peripheral abnormalities that can explain the development or maintenance of high arterial pressure in obesity have been identified. These include activation of the sympathetic nervous system and the renin-angiotensin–aldosterone system. Obesity is also associated with endothelial dysfunction and renal functional abnormalities that may play a role in the development of hypertension. The continuing discovery of mechanisms regulating appetite and metabolism is likely to lead to new therapies for obesity-induced hypertension. Better understanding of leptin signaling in the hypothalamus and the mechanisms of leptin resistance should facilitate therapeutic approaches to reverse the phenomenon of selective leptin resistance. Other hunger and satiety signals such as ghrelin and peptide YY are potentially attractive therapeutic strategies for treatment of obesity and its complications. These recent discoveries should lead to novel strategies for treatment of obesity and hypertension.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825895871132545","@type":"Researcher","foaf:name":[{"@value":"Kamal Rahmouni"}],"jpcoar:affiliationName":[{"@value":"From the Specialized Center of Research in Hypertension Genetics, Cardiovascular Center, the Department of Internal Medicine and the General Clinical Research Center, University of Iowa, Iowa City."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895871132547","@type":"Researcher","foaf:name":[{"@value":"Marcelo L.G. Correia"}],"jpcoar:affiliationName":[{"@value":"From the Specialized Center of Research in Hypertension Genetics, Cardiovascular Center, the Department of Internal Medicine and the General Clinical Research Center, University of Iowa, Iowa City."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895871132546","@type":"Researcher","foaf:name":[{"@value":"William G. Haynes"}],"jpcoar:affiliationName":[{"@value":"From the Specialized Center of Research in Hypertension Genetics, Cardiovascular Center, the Department of Internal Medicine and the General Clinical Research Center, University of Iowa, Iowa City."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895871132544","@type":"Researcher","foaf:name":[{"@value":"Allyn L. Mark"}],"jpcoar:affiliationName":[{"@value":"From the Specialized Center of Research in Hypertension Genetics, Cardiovascular Center, the Department of Internal Medicine and the General Clinical Research Center, University of Iowa, Iowa City."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0194911X"},{"@type":"EISSN","@value":"15244563"}],"prism:publicationName":[{"@value":"Hypertension"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2005-01","prism:volume":"45","prism:number":"1","prism:startingPage":"9","prism:endingPage":"14"},"reviewed":"false","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/01.HYP.0000151325.83008.b4"}],"createdAt":"2004-12-07","modifiedAt":"2024-05-12","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050568772240575872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Intra-abdominal fat accumulation is a hypertension risk factor in young adulthood: A cross-sectional study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002216075793792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Adipose tissue–specific dysregulation of angiotensinogen by oxidative stress in obesity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233405541760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mineralocorticoid receptor activation in obesity hypertension"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181978107008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Stroke, cerebrovascular diseases and vascular cognitive impairment in Africa"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694364679917184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effects of Sleeve Gastrectomy on Blood Pressure and the Renal Renin–Angiotensin System in Rats with Diet‐Induced Obesity"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205233666816","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Longitudinal Study on Risk Factors for Onset of Hypertension"},{"@language":"ja","@value":"高血圧発症因子に関する縦断的研究"},{"@language":"ja-Kana","@value":"コウケツアツ ハッショウ インシ ニ カンスル ジュウダンテキ ケンキュウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206301030144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Lifestyle modification increases serum testosterone level and decrease central blood pressure in overweight and obese men"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206444475648","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Internal Medicine Corresponding to Both the Mass and Individuals - Pathophisiology and Treatment of Hypertension"},{"@language":"ja","@value":"マスと個に対応する内科学～高血圧の病態と治療～"},{"@value":"会頭講演 マスと個に対応する内科学--高血圧の病態と治療"},{"@language":"ja-Kana","@value":"カイトウ コウエン マス ト コ ニ タイオウスル ナイカガク コウケツアツ ノ ビョウタイ ト チリョウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206444623232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"2. 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