{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895996513408.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1242/dev.051714"}},{"identifier":{"@type":"URI","@value":"http://journals.biologists.com/dev/article-pdf/137/24/4271/1157650/4271.pdf"}}],"dc:title":[{"@value":"Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Sonic hedgehog signalling is essential for the embryonic development of many tissues including the central nervous system, where it controls the pattern of cellular differentiation. A genome-wide screen of neural progenitor cells to evaluate the Shh signalling-regulated transcriptome identified the forkhead transcription factor Foxj1. In both chick and mouse Foxj1 is expressed in the ventral midline of the neural tube in cells that make up the floor plate. Consistent with the role of Foxj1 in the formation of long motile cilia, floor plate cells produce cilia that are longer than the primary cilia found elsewhere in the neural tube, and forced expression of Foxj1 in neuroepithelial cells is sufficient to increase cilia length. In addition, the expression of Foxj1 in the neural tube and in an Shh-responsive cell line attenuates intracellular signalling by decreasing the activity of Gli proteins, the transcriptional mediators of Shh signalling. We show that this function of Foxj1 depends on cilia. Nevertheless, floor plate identity and ciliogenesis are unaffected in mouse embryos lacking Foxj1 and we provide evidence that additional transcription factors expressed in the floor plate share overlapping functions with Foxj1. Together, these findings identify a novel mechanism that modifies the cellular response to Shh signalling and reveal morphological and functional features of the amniote floor plate that distinguish these cells from the rest of the neuroepithelium.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825895996513411","@type":"Researcher","foaf:name":[{"@value":"Catarina Cruz"}],"jpcoar:affiliationName":[{"@value":"MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK."},{"@value":"Programa Doutoral em Biologia Experimental e Biomedicina, Department of Zoology, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra 3004-517, Portugal."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895996513420","@type":"Researcher","foaf:name":[{"@value":"Vanessa Ribes"}],"jpcoar:affiliationName":[{"@value":"MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895996513419","@type":"Researcher","foaf:name":[{"@value":"Eva Kutejova"}],"jpcoar:affiliationName":[{"@value":"MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895996513416","@type":"Researcher","foaf:name":[{"@value":"Jordi Cayuso"}],"jpcoar:affiliationName":[{"@value":"Instituto de Biología Molecular de Barcelona, CSIC, Parc Científic de Barcelona, C/Josep Samitier 1-5, Barcelona, 08028, Spain."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895996513421","@type":"Researcher","foaf:name":[{"@value":"Victoria Lawson"}],"jpcoar:affiliationName":[{"@value":"MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895996513418","@type":"Researcher","foaf:name":[{"@value":"Dominic Norris"}],"jpcoar:affiliationName":[{"@value":"MRC Mammalian Genetics Unit, Harwell, OX11 0RD, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895996513423","@type":"Researcher","foaf:name":[{"@value":"Jonathan Stevens"}],"jpcoar:affiliationName":[{"@value":"MRC Mammalian Genetics Unit, Harwell, OX11 0RD, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895996513280","@type":"Researcher","foaf:name":[{"@value":"Megan Davey"}],"jpcoar:affiliationName":[{"@value":"Division of Genetics and Genomics, Roslin Institute, Roslin, EH25 9PS, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895996513414","@type":"Researcher","foaf:name":[{"@value":"Ken Blight"}],"jpcoar:affiliationName":[{"@value":"Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895996513408","@type":"Researcher","foaf:name":[{"@value":"Fiona Bangs"}],"jpcoar:affiliationName":[{"@value":"Biology and Biochemistry Department, University of Bath, Bath BA2 7AY, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895996513415","@type":"Researcher","foaf:name":[{"@value":"Anita Mynett"}],"jpcoar:affiliationName":[{"@value":"MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895996513409","@type":"Researcher","foaf:name":[{"@value":"Elizabeth Hirst"}],"jpcoar:affiliationName":[{"@value":"MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895996513417","@type":"Researcher","foaf:name":[{"@value":"Rachel Chung"}],"jpcoar:affiliationName":[{"@value":"MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895996513412","@type":"Researcher","foaf:name":[{"@value":"Nikolaos Balaskas"}],"jpcoar:affiliationName":[{"@value":"MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895996513422","@type":"Researcher","foaf:name":[{"@value":"Steven L. Brody"}],"jpcoar:affiliationName":[{"@value":"Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895996513410","@type":"Researcher","foaf:name":[{"@value":"Elisa Marti"}],"jpcoar:affiliationName":[{"@value":"Instituto de Biología Molecular de Barcelona, CSIC, Parc Científic de Barcelona, C/Josep Samitier 1-5, Barcelona, 08028, Spain."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895996513413","@type":"Researcher","foaf:name":[{"@value":"James Briscoe"}],"jpcoar:affiliationName":[{"@value":"MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK."}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14779129"},{"@type":"PISSN","@value":"09501991"}],"prism:publicationName":[{"@value":"Development"}],"dc:publisher":[{"@value":"The Company of Biologists"}],"prism:publicationDate":"2010-12-15","prism:volume":"137","prism:number":"24","prism:startingPage":"4271","prism:endingPage":"4282"},"reviewed":"false","url":[{"@id":"http://journals.biologists.com/dev/article-pdf/137/24/4271/1157650/4271.pdf"}],"createdAt":"2010-11-23","modifiedAt":"2021-04-26","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202585197952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"High variability of expression profiles of homeologous genes for Wnt, Hh, Notch, and Hippo signaling pathways in  Xenopus laevis"}]},{"@id":"https://cir.nii.ac.jp/crid/1050856196397492224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Resolution of the curse of dimensionality in single-cell RNA sequencing data analysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1050869456403461760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Expression of Indian hedgehog signaling in murine oviductal infundibulum and its relationship with epithelial homeostasis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707533867136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The PCP protein Vangl2 regulates migration of hindbrain motor neurons by acting in floor plate cells, and independently of cilia function"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1242/dev.051714"},{"@type":"CROSSREF","@value":"10.1016/j.ydbio.2013.08.017_references_DOI_AotbUH4PnMpbxluC4tzUlnzRU0N"},{"@type":"CROSSREF","@value":"10.1007/s00441-022-03722-w_references_DOI_AotbUH4PnMpbxluC4tzUlnzRU0N"},{"@type":"CROSSREF","@value":"10.26508/lsa.202201591_references_DOI_AotbUH4PnMpbxluC4tzUlnzRU0N"},{"@type":"CROSSREF","@value":"10.1101/2022.05.02.490246_references_DOI_AotbUH4PnMpbxluC4tzUlnzRU0N"},{"@type":"CROSSREF","@value":"10.1016/j.ydbio.2016.12.006_references_DOI_AotbUH4PnMpbxluC4tzUlnzRU0N"}]}