{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825896055880960.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1128/jvi.78.12.6469-6479.2004"}},{"identifier":{"@type":"URI","@value":"https://journals.asm.org/doi/pdf/10.1128/JVI.78.12.6469-6479.2004"}}],"dc:title":[{"@value":"Inter- and Intragenus Structural Variations in Caliciviruses and Their Functional Implications"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>ABSTRACT</jats:title>\n          <jats:p>\n            The family\n            <jats:italic>Caliciviridae</jats:italic>\n            is divided into four genera and consists of single-stranded RNA viruses with hosts ranging from humans to a wide variety of animals. Human caliciviruses are the major cause of outbreaks of acute nonbacterial gastroenteritis, whereas animal caliciviruses cause various host-dependent illnesses with a documented potential for zoonoses. To investigate inter- and intragenus structural variations and to provide a better understanding of the structural basis of host specificity and strain diversity, we performed structural studies of the recombinant capsid of Grimsby virus, the recombinant capsid of Parkville virus, and San Miguel sea lion virus serotype 4 (SMSV4), which are representative of the genera\n            <jats:italic>Norovirus</jats:italic>\n            (genogroup 2),\n            <jats:italic>Sapovirus</jats:italic>\n            , and\n            <jats:italic>Vesivirus</jats:italic>\n            , respectively. A comparative analysis of these structures was performed with that of the recombinant capsid of Norwalk virus, a prototype member of\n            <jats:italic>Norovirus</jats:italic>\n            genogroup 1. Although these capsids share a common architectural framework of 90 dimers of the capsid protein arranged on a T=3 icosahedral lattice with a modular domain organization of the subunit consisting of a shell (S) domain and a protrusion (P) domain, they exhibit distinct differences. The distally located P2 subdomain of P shows the most prominent differences both in shape and in size, in accordance with the observed sequence variability. Another major difference is in the relative orientation between the S and P domains, particularly between those of noroviruses and other caliciviruses. Despite being a human pathogen, the Parkville virus capsid shows more structural similarity to SMSV4, an animal calicivirus, suggesting a closer relationship between sapoviruses and animal caliciviruses. These comparative structural studies of caliciviruses provide a functional rationale for the unique modular domain organization of the capsid protein with an embedded flexibility reminiscent of an antibody structure. The highly conserved S domain functions to provide an icosahedral scaffold; the hypervariable P2 subdomain may function as a replaceable module to confer host specificity and strain diversity; and the P1 subdomain, located between S and P2, provides additional fine-tuning to position the P2 subdomain.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825896055880962","@type":"Researcher","foaf:name":[{"@value":"Rong Chen"}],"jpcoar:affiliationName":[{"@value":"Verna and Marrs McLean Department of Biochemistry and Molecular Biology"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896055880966","@type":"Researcher","foaf:name":[{"@value":"John D. Neill"}],"jpcoar:affiliationName":[{"@value":"National Animal Disease Center, Agriculture Research Service, U.S. Department of Agriculture, Ames, Iowa 50010"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896055880960","@type":"Researcher","foaf:name":[{"@value":"Jacqueline S. Noel"}],"jpcoar:affiliationName":[{"@value":"Viral Gastroenteritis Unit, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896055880964","@type":"Researcher","foaf:name":[{"@value":"Anne M. Hutson"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896055880961","@type":"Researcher","foaf:name":[{"@value":"Roger I. Glass"}],"jpcoar:affiliationName":[{"@value":"Viral Gastroenteritis Unit, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896055880965","@type":"Researcher","foaf:name":[{"@value":"Mary K. Estes"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896055880963","@type":"Researcher","foaf:name":[{"@value":"B. V. Venkataram Prasad"}],"jpcoar:affiliationName":[{"@value":"Verna and Marrs McLean Department of Biochemistry and Molecular Biology"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0022538X"},{"@type":"EISSN","@value":"10985514"}],"prism:publicationName":[{"@value":"Journal of Virology"}],"dc:publisher":[{"@value":"American Society for Microbiology"}],"prism:publicationDate":"2004-06-15","prism:volume":"78","prism:number":"12","prism:startingPage":"6469","prism:endingPage":"6479"},"reviewed":"false","dc:rights":["https://journals.asm.org/non-commercial-tdm-license"],"url":[{"@id":"https://journals.asm.org/doi/pdf/10.1128/JVI.78.12.6469-6479.2004"}],"createdAt":"2004-05-26","modifiedAt":"2022-03-05","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002218467592576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Structural Basis for Broad Detection of Genogroup II Noroviruses by a Monoclonal Antibody That Binds to a Site Occluded in the Viral Particle"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239442615808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evolutionary Constraints on the Norovirus Pandemic Variant GII.4_2006b over the Five-Year Persistence in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285705164316800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Epidemics of GI.2 sapovirus in gastroenteritis outbreaks during 2012−2013 in Osaka City, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185504503040","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Novel monoclonal antibodies broadly reactive to human recombinant sapovirus‐like particles"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643397264000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mechanism of Cell Culture Adaptation of an Enteric Calicivirus, the Porcine Sapovirus Cowden Strain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643397510528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Antigenic and Cryo-Electron Microscopy Structure Analysis of a Chimeric Sapovirus Capsid"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656374138496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"First complete genome sequences of genogroup V, genotype 3 porcine sapoviruses: common 5′-terminal genomic feature of sapoviruses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659861096576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Vesivirus 2117 capsids more closely resemble sapovirus and lagovirus particles than other known vesivirus structures"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707377645056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Atomic Structure of the Human Sapovirus Capsid Reveals a Unique Capsid Protein Conformation in Caliciviruses"}]},{"@id":"https://cir.nii.ac.jp/crid/1390852405228194304","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Review Norovirus"},{"@language":"ja","@value":"ウイルス　ノロウイルス総説　2020"},{"@language":"ja-Kana","@value":"ウイルス ノロウイルス ソウセツ 2020"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1128/jvi.78.12.6469-6479.2004"},{"@type":"CROSSREF","@value":"10.1128/jvi.06868-11_references_DOI_2WuZMhf1ENv5b8rZPGpek59mBh1"},{"@type":"CROSSREF","@value":"10.3389/fmicb.2017.00410_references_DOI_2WuZMhf1ENv5b8rZPGpek59mBh1"},{"@type":"CROSSREF","@value":"10.2222/jsv.70.117_references_DOI_2WuZMhf1ENv5b8rZPGpek59mBh1"},{"@type":"CROSSREF","@value":"10.1002/jmv.24451_references_DOI_2WuZMhf1ENv5b8rZPGpek59mBh1"},{"@type":"CROSSREF","@value":"10.1111/j.1348-0421.2012.00499.x_references_DOI_2WuZMhf1ENv5b8rZPGpek59mBh1"},{"@type":"CROSSREF","@value":"10.1128/jvi.02197-15_references_DOI_2WuZMhf1ENv5b8rZPGpek59mBh1"},{"@type":"CROSSREF","@value":"10.1128/jvi.02916-15_references_DOI_2WuZMhf1ENv5b8rZPGpek59mBh1"},{"@type":"CROSSREF","@value":"10.1007/s11262-017-1481-8_references_DOI_2WuZMhf1ENv5b8rZPGpek59mBh1"},{"@type":"CROSSREF","@value":"10.1099/jgv.0.000658_references_DOI_2WuZMhf1ENv5b8rZPGpek59mBh1"},{"@type":"CROSSREF","@value":"10.1128/jvi.00298-22_references_DOI_2WuZMhf1ENv5b8rZPGpek59mBh1"}]}