{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825896095349632.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.7545954"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.7545954"}},{"identifier":{"@type":"NAID","@value":"80007894041"}}],"dc:title":[{"@value":"A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene\n            <i>BRCA1</i>"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            A strong candidate for the 17q-linked\n            <jats:italic>BRCA1</jats:italic>\n            gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods. Probable predisposing mutations have been detected in five of eight kindreds presumed to segregate\n            <jats:italic>BRCA1</jats:italic>\n            susceptibility alleles. The mutations include an 11-base pair deletion, a 1-base pair insertion, a stop codon, a missense substitution, and an inferred regulatory mutation. The\n            <jats:italic>BRCA1</jats:italic>\n            gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. This protein contains a zinc finger domain in its amino-terminal region, but is otherwise unrelated to previously described proteins. Identification of\n            <jats:italic>BRCA1</jats:italic>\n            should facilitate early diagnosis of breast and ovarian cancer susceptibility in some individuals as well as a better understanding of breast cancer biology.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825896095349644","@type":"Researcher","foaf:name":[{"@value":"Yoshio Miki"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Informatics, University of Utah Medical Center, Salt Lake City, UT 84132, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349513","@type":"Researcher","foaf:name":[{"@value":"Jeff Swensen"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Informatics, University of Utah Medical Center, Salt Lake City, UT 84132, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349510","@type":"Researcher","foaf:name":[{"@value":"Donna Shattuck-Eidens"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349763","@type":"Researcher","foaf:name":[{"@value":"P. Andrew Futreal"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Trangle Park, NC 27709, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349643","@type":"Researcher","foaf:name":[{"@value":"Keith Harshman"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349632","@type":"Researcher","foaf:name":[{"@value":"Sean Tavtigian"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349760","@type":"Researcher","foaf:name":[{"@value":"Qingyun Liu"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349639","@type":"Researcher","foaf:name":[{"@value":"Charles Cochran"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Trangle Park, NC 27709, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349507","@type":"Researcher","foaf:name":[{"@value":"L. Michelle Bennett"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Trangle Park, NC 27709, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349649","@type":"Researcher","foaf:name":[{"@value":"Wei Ding"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349505","@type":"Researcher","foaf:name":[{"@value":"Russell Bell"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349647","@type":"Researcher","foaf:name":[{"@value":"Judith Rosenthal"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349651","@type":"Researcher","foaf:name":[{"@value":"Charles Hussey"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349761","@type":"Researcher","foaf:name":[{"@value":"Thanh Tran"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349652","@type":"Researcher","foaf:name":[{"@value":"Melody McClure"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349509","@type":"Researcher","foaf:name":[{"@value":"Cheryl Frye"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349637","@type":"Researcher","foaf:name":[{"@value":"Tom Hattier"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349640","@type":"Researcher","foaf:name":[{"@value":"Robert Phelps"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349519","@type":"Researcher","foaf:name":[{"@value":"Astrid Haugen-Strano"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Trangle Park, NC 27709, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349508","@type":"Researcher","foaf:name":[{"@value":"Harold Katcher"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349515","@type":"Researcher","foaf:name":[{"@value":"Kazuko Yakumo"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Informatics, University of Utah Medical Center, Salt Lake City, UT 84132, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349645","@type":"Researcher","foaf:name":[{"@value":"Zahra Gholami"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349520","@type":"Researcher","foaf:name":[{"@value":"Daniel Shaffer"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349514","@type":"Researcher","foaf:name":[{"@value":"Steven Stone"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349517","@type":"Researcher","foaf:name":[{"@value":"Steven Bayer"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349636","@type":"Researcher","foaf:name":[{"@value":"Christian Wray"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349635","@type":"Researcher","foaf:name":[{"@value":"Robert Bogden"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349650","@type":"Researcher","foaf:name":[{"@value":"Priya Dayananth"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349506","@type":"Researcher","foaf:name":[{"@value":"John Ward"}],"jpcoar:affiliationName":[{"@value":"Department of Internal Medicine, University of Utah Medical Center, Salt Lake City, UT 84132, USA.."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349516","@type":"Researcher","foaf:name":[{"@value":"Patricia Tonin"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Genetics, McGill University, Montreal, Quebec, H3G 1A4, Canada.."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349512","@type":"Researcher","foaf:name":[{"@value":"Steven Narod"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Genetics, McGill University, Montreal, Quebec, H3G 1A4, Canada.."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349633","@type":"Researcher","foaf:name":[{"@value":"Pam K. Bristow"}],"jpcoar:affiliationName":[{"@value":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349521","@type":"Researcher","foaf:name":[{"@value":"Frank H. Norris"}],"jpcoar:affiliationName":[{"@value":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349646","@type":"Researcher","foaf:name":[{"@value":"Leah Helvering"}],"jpcoar:affiliationName":[{"@value":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349634","@type":"Researcher","foaf:name":[{"@value":"Paul Morrison"}],"jpcoar:affiliationName":[{"@value":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349511","@type":"Researcher","foaf:name":[{"@value":"Paul Rosteck"}],"jpcoar:affiliationName":[{"@value":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349642","@type":"Researcher","foaf:name":[{"@value":"Mei Lai"}],"jpcoar:affiliationName":[{"@value":"Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349518","@type":"Researcher","foaf:name":[{"@value":"J. Carl Barrett"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Trangle Park, NC 27709, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349762","@type":"Researcher","foaf:name":[{"@value":"Cathryn Lewis"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Informatics, University of Utah Medical Center, Salt Lake City, UT 84132, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349641","@type":"Researcher","foaf:name":[{"@value":"Susan Neuhausen"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Informatics, University of Utah Medical Center, Salt Lake City, UT 84132, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349648","@type":"Researcher","foaf:name":[{"@value":"Lisa Cannon-Albright"}],"jpcoar:affiliationName":[{"@value":"Department of Internal Medicine, University of Utah Medical Center, Salt Lake City, UT 84132, USA.."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349504","@type":"Researcher","foaf:name":[{"@value":"David Goldgar"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Informatics, University of Utah Medical Center, Salt Lake City, UT 84132, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349638","@type":"Researcher","foaf:name":[{"@value":"Roger Wiseman"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Trangle Park, NC 27709, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349653","@type":"Researcher","foaf:name":[{"@value":"Alexander Kamb"}],"jpcoar:affiliationName":[{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896095349654","@type":"Researcher","foaf:name":[{"@value":"Mark H. Skolnick"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Informatics, University of Utah Medical Center, Salt Lake City, UT 84132, USA."},{"@value":"Myriad Genetics, Salt Lake City, UT 84108, USA."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00368075"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00368075"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"1994-10-07","prism:volume":"266","prism:number":"5182","prism:startingPage":"66","prism:endingPage":"71"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/science.7545954"}],"createdAt":"2006-10-06","modifiedAt":"2024-01-15","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050012570395059072","@type":"Article","resourceType":"学術雑誌論文(journal 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