{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825896149563136.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.1175151"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.1175151"}}],"dc:title":[{"@value":"Generation of Medaka Fish Haploid Embryonic Stem Cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Haploid Medaka Stem Cells</jats:title>\n          <jats:p>\n            Although diploid embryonic stem cells have been generated by various means, there would also be value in deriving haploid stem cells. In these cells, recessive mutations in essential genes would show phenotypes that would not be apparent in heterozygous animals.\n            <jats:bold>\n              Yi\n              <jats:italic>et al.</jats:italic>\n            </jats:bold>\n            (p.\n            <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" page=\"430\" related-article-type=\"in-this-issue\" vol=\"326\" xlink:href=\"10.1126/science.1175151\">430</jats:related-article>\n            ) used the medaka fish model system to generate haploid stem cells that show stable growth and pluripotency. In addition, a fertile female medaka fish was produced by haploid embryonic stem cell nuclear transfer into a normal egg. This system has potential for analyzing recessive genes, for example, in disease phenotypes or in various cell lineages in culture.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825896149563136","@type":"Researcher","foaf:name":[{"@value":"Meisheng Yi"}],"jpcoar:affiliationName":[{"@value":"Department of Biological Sciences, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896149563138","@type":"Researcher","foaf:name":[{"@value":"Ni Hong"}],"jpcoar:affiliationName":[{"@value":"Department of Biological Sciences, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896149563137","@type":"Researcher","foaf:name":[{"@value":"Yunhan Hong"}],"jpcoar:affiliationName":[{"@value":"Department of Biological Sciences, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"2009-10-16","prism:volume":"326","prism:number":"5951","prism:startingPage":"430","prism:endingPage":"433"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/science.1175151"}],"createdAt":"2009-10-15","modifiedAt":"2024-01-10","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050869987401442816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Isogenic fish sperm produced by transplanting gynogenetic haploid-derived germ cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233087780352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Development of interspecies cloned embryos reconstructed with rabbit (<i>Oryctolagus cuniculus</i>) oocytes and cynomolgus monkey (<i>Macaca fascicularis</i>) fibroblast cell nuclei"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233532545408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Autosomal gsdf acts as a male sex initiator in the fish medaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711954798208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Large hypomethylated domains serve as strong repressive machinery for key developmental genes in vertebrates"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169045084032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Induction of the G2/M transition stabilizes haploid embryonic stem cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189446196096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genome Editing Using Mammalian Haploid Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656862848128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genome Engineering Using Haploid Embryonic Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658461350144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Production of viable trout offspring derived from frozen whole fish"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1126/science.1175151"},{"@type":"CROSSREF","@value":"10.1038/srep19738_references_DOI_8VxauQ22UBi4Q5eZPmUjs9yza5J"},{"@type":"CROSSREF","@value":"10.1242/dev.108548_references_DOI_8VxauQ22UBi4Q5eZPmUjs9yza5J"},{"@type":"CROSSREF","@value":"10.1093/biolre/ioaf001_references_DOI_8VxauQ22UBi4Q5eZPmUjs9yza5J"},{"@type":"CROSSREF","@value":"10.1017/s0967199412000081_references_DOI_8VxauQ22UBi4Q5eZPmUjs9yza5J"},{"@type":"CROSSREF","@value":"10.3390/ijms161023604_references_DOI_8VxauQ22UBi4Q5eZPmUjs9yza5J"},{"@type":"CROSSREF","@value":"10.1038/srep16045_references_DOI_8VxauQ22UBi4Q5eZPmUjs9yza5J"},{"@type":"CROSSREF","@value":"10.1242/dev.110726_references_DOI_8VxauQ22UBi4Q5eZPmUjs9yza5J"},{"@type":"CROSSREF","@value":"10.1016/bs.pmbts.2017.09.001_references_DOI_8VxauQ22UBi4Q5eZPmUjs9yza5J"}]}