{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825896152700928.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.0609507104"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.0609507104"}}],"dc:title":[{"@value":"A secretory pathway-localized cation diffusion facilitator confers plant manganese tolerance"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n                    Manganese toxicity is a major problem for plant growth in acidic soils, but cellular mechanisms that facilitate growth in such conditions have not been clearly delineated. Established mechanisms that counter metal toxicity in plants involve chelation and cytoplasmic export of the metal across the plasma or vacuolar membranes out of the cell or sequestered into a large organelle, respectively. We report here that expression of the\n                    <jats:italic>Arabidopsis</jats:italic>\n                    and poplar MTP11 cation diffusion facilitators in a manganese-hypersensitive yeast mutant restores manganese tolerance to wild-type levels. Microsomes from yeast expressing\n                    <jats:italic>AtMTP11</jats:italic>\n                    exhibit enhanced manganese uptake. In accord with a presumed function of MTP11 in manganese tolerance,\n                    <jats:italic>Arabidopsis mtp11</jats:italic>\n                    mutants are hypersensitive to elevated levels of manganese, whereas plants overexpressing\n                    <jats:italic>MTP11</jats:italic>\n                    are hypertolerant. In contrast, sensitivity to manganese deficiency is slightly decreased in mutants and increased in overexpressing lines. Promoter-GUS studies showed that\n                    <jats:italic>AtMTP11</jats:italic>\n                    is most highly expressed in root tips, shoot margins, and hydathodes, but not in epidermal cells and trichomes, which are generally associated with manganese accumulation. Surprisingly, imaging of MTP11–EYFP fusions demonstrated that MTP11 localizes neither to the plasma membrane nor to the vacuole, but to a punctate endomembrane compartment that largely coincides with the distribution of the trans-Golgi marker sialyl transferase. Golgi-based manganese accumulation might therefore result in manganese tolerance through vesicular trafficking and exocytosis. In accord with this proposal,\n                    <jats:italic>Arabidopsis mtp11</jats:italic>\n                    mutants exhibit enhanced manganese concentrations in shoots and roots. We propose that Golgi-mediated exocytosis comprises a conserved mechanism for heavy metal tolerance in plants.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380576120697176070","@type":"Researcher","foaf:name":[{"@value":"Edgar Peiter"}],"jpcoar:affiliationName":[{"@value":"*Department of Biology, University of York, P.O. Box 373, York YO10 5YW, United Kingdom;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576120697176064","@type":"Researcher","foaf:name":[{"@value":"Barbara Montanini"}],"jpcoar:affiliationName":[{"@value":"Unité Mixte de Recherche, Institut National de la Recherche Agronomique/Université Henri Poincaré, 1136 Interactions Arbres-Microorganismes, Nancy-Université, 54506 Vandoeuvre-les-Nancy, France; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576120697176066","@type":"Researcher","foaf:name":[{"@value":"Anthony Gobert"}],"jpcoar:affiliationName":[{"@value":"*Department of Biology, University of York, P.O. Box 373, York YO10 5YW, United Kingdom;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576120697176072","@type":"Researcher","foaf:name":[{"@value":"Pai Pedas"}],"jpcoar:affiliationName":[{"@value":"Plant and Soil Science Laboratory, Department of Agricultural Science, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Copenhagen, Denmark"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576120697176071","@type":"Researcher","foaf:name":[{"@value":"Søren Husted"}],"jpcoar:affiliationName":[{"@value":"Plant and Soil Science Laboratory, Department of Agricultural Science, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Copenhagen, Denmark"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576120697176065","@type":"Researcher","foaf:name":[{"@value":"Frans J. M. Maathuis"}],"jpcoar:affiliationName":[{"@value":"*Department of Biology, University of York, P.O. Box 373, York YO10 5YW, United Kingdom;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576120697176067","@type":"Researcher","foaf:name":[{"@value":"Damien Blaudez"}],"jpcoar:affiliationName":[{"@value":"Unité Mixte de Recherche, Institut National de la Recherche Agronomique/Université Henri Poincaré, 1136 Interactions Arbres-Microorganismes, Nancy-Université, 54506 Vandoeuvre-les-Nancy, France; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576120697176069","@type":"Researcher","foaf:name":[{"@value":"Michel Chalot"}],"jpcoar:affiliationName":[{"@value":"Unité Mixte de Recherche, Institut National de la Recherche Agronomique/Université Henri Poincaré, 1136 Interactions Arbres-Microorganismes, Nancy-Université, 54506 Vandoeuvre-les-Nancy, France; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576120697176068","@type":"Researcher","foaf:name":[{"@value":"Dale Sanders"}],"jpcoar:affiliationName":[{"@value":"*Department of Biology, University of York, P.O. Box 373, York YO10 5YW, United Kingdom;"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"2007-05-15","prism:volume":"104","prism:number":"20","prism:startingPage":"8532","prism:endingPage":"8537"},"reviewed":"false","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.0609507104"}],"createdAt":"2007-05-09","modifiedAt":"2022-04-12","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004234643512448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mn tolerance in rice is mediated by MTP8.1, a member of the cation diffusion facilitator family"}]},{"@id":"https://cir.nii.ac.jp/crid/1360025431098799616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Metal Transport Systems in Plants"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166765329664","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A polarly localized transporter for efficient manganese uptake in rice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118704762752","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Roles of subcellular metal homeostasis in crop improvement"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641113427584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Key to Mn Homeostasis in Plants: Regulation of Mn Transporters"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656169206016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A member of cation diffusion facilitator family, MTP11, is required for manganese tolerance and high fertility in rice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848659670649856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Tonoplast-Localized Transporter MTP8.2 Contributes to Manganese Detoxification in the Shoots and Roots of Oryza sativa L."}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660445301760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A high molecular mass zinc transporter <scp>MTP</scp>12 forms a functional heteromeric complex with <scp>MTP</scp>5 in the Golgi in <i>Arabidopsis thaliana</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865816803507072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Local distribution of manganese to leaf sheath is mediated by OsNramp5 in rice"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1073/pnas.0609507104"},{"@type":"CROSSREF","@value":"10.1093/jxb/ert243_references_DOI_SkLYQVX2ltAFpkT9bdJd4qYAXE5"},{"@type":"CROSSREF","@value":"10.1146/annurev-arplant-062923-021424_references_DOI_SkLYQVX2ltAFpkT9bdJd4qYAXE5"},{"@type":"CROSSREF","@value":"10.1038/nplants.2015.170_references_DOI_SkLYQVX2ltAFpkT9bdJd4qYAXE5"},{"@type":"CROSSREF","@value":"10.1093/jxb/erab018_references_DOI_SkLYQVX2ltAFpkT9bdJd4qYAXE5"},{"@type":"CROSSREF","@value":"10.1007/s00425-018-2890-1_references_DOI_SkLYQVX2ltAFpkT9bdJd4qYAXE5"},{"@type":"CROSSREF","@value":"10.1093/pcp/pcx082_references_DOI_SkLYQVX2ltAFpkT9bdJd4qYAXE5"},{"@type":"CROSSREF","@value":"10.1111/febs.13252_references_DOI_SkLYQVX2ltAFpkT9bdJd4qYAXE5"},{"@type":"CROSSREF","@value":"10.1111/nph.19454_references_DOI_SkLYQVX2ltAFpkT9bdJd4qYAXE5"},{"@type":"CROSSREF","@value":"10.1016/j.tplants.2016.12.005_references_DOI_SkLYQVX2ltAFpkT9bdJd4qYAXE5"}]}