{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825896284500352.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/ni1370"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/ni1370.pdf"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/ni1370"}},{"identifier":{"@type":"PMID","@value":"16878136"}},{"identifier":{"@type":"NAID","@value":"80018933412"}}],"dc:title":[{"@value":"Invariant Vα19i T cells regulate autoimmune inflammation"}],"description":[{"notation":[{"@value":"T cells expressing an invariant V(alpha)19-J(alpha)33 T cell receptor alpha-chain (V(alpha)19i TCR) are restricted by the nonpolymorphic major histocompatibility complex class Ib molecule MR1. Whether V(alpha)19i T cells are involved in autoimmunity is not understood. Here we demonstrate that T cells expressing the V(alpha)19i TCR transgene inhibited the induction and progression of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. Similarly, EAE was exacerbated in MR1-deficient mice, which lack V(alpha)19i T cells. EAE suppression was accompanied by reduced production of inflammatory mediators and increased secretion of interleukin 10. Interleukin 10 production occurred at least in part through interactions between B cells and V(alpha)19i T cells mediated by the ICOS costimulatory molecule. These results suggest an immunoregulatory function for V(alpha)19i T cells."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825896284500352","@type":"Researcher","foaf:name":[{"@value":"J Ludovic Croxford"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751140454784","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50266045"},{"@type":"NRID","@value":"1000050266045"},{"@type":"NRID","@value":"9000242075361"},{"@type":"NRID","@value":"9000412351893"},{"@type":"NRID","@value":"9000024032248"},{"@type":"NRID","@value":"9000001031531"},{"@type":"NRID","@value":"9000347038783"},{"@type":"NRID","@value":"9000001669832"},{"@type":"NRID","@value":"9000350631069"},{"@type":"NRID","@value":"9000316210489"},{"@type":"NRID","@value":"9000262366997"},{"@type":"NRID","@value":"9000001904876"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/miyakesachiko"}],"foaf:name":[{"@value":"Sachiko Miyake"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896284500353","@type":"Researcher","foaf:name":[{"@value":"Yi-Ying Huang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896284500354","@type":"Researcher","foaf:name":[{"@value":"Michio Shimamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896284500355","@type":"Researcher","foaf:name":[{"@value":"Takashi Yamamura"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"15292908"},{"@type":"EISSN","@value":"15292916"}],"prism:publicationName":[{"@value":"Nature Immunology"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2006-07-30","prism:volume":"7","prism:number":"9","prism:startingPage":"987","prism:endingPage":"994"},"reviewed":"false","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://www.nature.com/articles/ni1370.pdf"},{"@id":"http://www.nature.com/articles/ni1370"}],"createdAt":"2006-07-30","modifiedAt":"2024-02-05","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Antigens,%20Differentiation,%20T-Lymphocyte","dc:title":"Antigens, Differentiation, T-Lymphocyte"},{"@id":"https://cir.nii.ac.jp/all?q=B-Lymphocytes","dc:title":"B-Lymphocytes"},{"@id":"https://cir.nii.ac.jp/all?q=Encephalomyelitis,%20Autoimmune,%20Experimental","dc:title":"Encephalomyelitis, Autoimmune, Experimental"},{"@id":"https://cir.nii.ac.jp/all?q=Multiple%20Sclerosis","dc:title":"Multiple Sclerosis"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Antigen,%20T-Cell,%20alpha-beta","dc:title":"Receptors, Antigen, T-Cell, alpha-beta"},{"@id":"https://cir.nii.ac.jp/all?q=Histocompatibility%20Antigens%20Class%20I","dc:title":"Histocompatibility Antigens Class I"},{"@id":"https://cir.nii.ac.jp/all?q=Immunoglobulin%20Variable%20Region","dc:title":"Immunoglobulin Variable Region"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Transgenic","dc:title":"Mice, Transgenic"},{"@id":"https://cir.nii.ac.jp/all?q=Lymphocyte%20Activation","dc:title":"Lymphocyte Activation"},{"@id":"https://cir.nii.ac.jp/all?q=T-Lymphocytes,%20Regulatory","dc:title":"T-Lymphocytes, Regulatory"},{"@id":"https://cir.nii.ac.jp/all?q=Interleukin-10","dc:title":"Interleukin-10"},{"@id":"https://cir.nii.ac.jp/all?q=Antigens,%20CD1","dc:title":"Antigens, CD1"},{"@id":"https://cir.nii.ac.jp/all?q=Inducible%20T-Cell%20Co-Stimulator%20Protein","dc:title":"Inducible T-Cell Co-Stimulator Protein"},{"@id":"https://cir.nii.ac.jp/all?q=Minor%20Histocompatibility%20Antigens","dc:title":"Minor Histocompatibility Antigens"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Antigens,%20CD1d","dc:title":"Antigens, CD1d"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002219005526784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Activation status of mucosal-associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004235779440128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"MAIT cells are activated and accumulated in the inflamed mucosa of ulcerative colitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236343207808","@type":"Article","resourceType":"学術雑誌論文(journal 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