{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825896286801792.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.4049/jimmunol.177.10.7303"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/jimmunol/article-pdf/177/10/7303/62649549/zim02206007303.pdf"}}],"dc:title":[{"@value":"Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>Comprehensive analysis of the gene expression profiles associated with human monocyte-to-macrophage differentiation and polarization toward M1 or M2 phenotypes led to the following main results: 1) M-CSF-driven monocyte-to-macrophage differentiation is associated with activation of cell cycle genes, substantiating the underestimated proliferation potential of monocytes. 2) M-CSF leads to expression of a substantial part of the M2 transcriptome, suggesting that under homeostatic conditions a default shift toward M2 occurs. 3) Modulation of genes involved in metabolic activities is a prominent feature of macrophage differentiation and polarization. 4) Lipid metabolism is a main category of modulated transcripts, with expected up-regulation of cyclo-oxygenase 2 in M1 cells and unexpected cyclo-oxygenase 1 up-regulation in M2 cells. 5) Each step is characterized by a different repertoire of G protein-coupled receptors, with five nucleotide receptors as novel M2-associated genes. 6) The chemokinome of polarized macrophages is profoundly diverse and new differentially expressed chemokines are reported. Thus, transcriptome profiling reveals novel molecules and signatures associated with human monocyte-to-macrophage differentiation and polarized activation which may represent candidate targets in pathophysiology.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380026068040731904","@type":"Researcher","foaf:name":[{"@value":"Fernando O Martinez"}],"jpcoar:affiliationName":[{"@value":"Istituto Clinico Humanitas , Rozzano ,"},{"@value":"Institute of General Pathology, University of Milan , Milan ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896286801793","@type":"Researcher","foaf:name":[{"@value":"Siamon Gordon"}],"jpcoar:affiliationName":[{"@value":"Sir William Dunn School of Pathology, University of Oxford , Oxford ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896286801795","@type":"Researcher","foaf:name":[{"@value":"Massimo Locati"}],"jpcoar:affiliationName":[{"@value":"Istituto Clinico Humanitas , Rozzano ,"},{"@value":"Institute of General Pathology, University of Milan , Milan ,"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896286801792","@type":"Researcher","foaf:name":[{"@value":"Alberto Mantovani"}],"jpcoar:affiliationName":[{"@value":"Istituto Clinico Humanitas , Rozzano ,"},{"@value":"Institute of General Pathology, University of Milan , Milan ,"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00221767"},{"@type":"EISSN","@value":"15506606"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00221767"}],"prism:publicationName":[{"@value":"The Journal of Immunology"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2006-11","prism:volume":"177","prism:number":"10","prism:startingPage":"7303","prism:endingPage":"7311"},"reviewed":"false","dc:rights":["https://academic.oup.com/pages/standard-publication-reuse-rights"],"url":[{"@id":"https://academic.oup.com/jimmunol/article-pdf/177/10/7303/62649549/zim02206007303.pdf"}],"createdAt":"2014-04-18","modifiedAt":"2026-02-02","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050011251823172480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Gpr137b is an orphan G-protein-coupled receptor associated with M2 macrophage polarization"}]},{"@id":"https://cir.nii.ac.jp/crid/1050576734232214400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Neutrophil S100A9 supports M2 macrophage niche formation in 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