{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825896322649344.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.aal4677"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1126/science.aal4677"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.aal4677"}}],"dc:title":[{"@value":"Paneth cells secrete lysozyme via secretory autophagy during bacterial infection of the intestine"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Foiling bad bugs' sneaky tricks</jats:title>\n                  <jats:p>\n                    Intestinal pathogens can invade host cells and disrupt critical cellular functions, including secretion. Secretion is necessary for the delivery of antimicrobial proteins that kill pathogenic bacteria. Bel\n                    <jats:italic>et al.</jats:italic>\n                    show that when intestinal epithelial cells sense an invading bacterial pathogen, they “reroute” the antimicrobial protein lysozyme through an alternative autophagy-based secretion pathway (see the Perspective by Kaser and Blumberg). This ensures lysozyme delivery to the gut lumen, which protects against further bacterial invasion. Secretory autophagy was triggered by endoplasmic reticulum stress and required signals from type 3 innate lymphoid cells. Thus, the innate immune response to gut pathogens co-opts autophagy in intestinal immune defense.\n                  </jats:p>\n                  <jats:p>\n                    <jats:italic>Science</jats:italic>\n                    , this issue p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6355\" page=\"1047\" related-article-type=\"in-this-issue\" vol=\"357\" xlink:href=\"10.1126/science.aal4677\">1047</jats:related-article>\n                    ; see also p.\n                    <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6355\" page=\"976\" related-article-type=\"in-this-issue\" vol=\"357\" xlink:href=\"10.1126/science.aao4158\">976</jats:related-article>\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825896322649345","@type":"Researcher","foaf:name":[{"@value":"Shai Bel"}],"jpcoar:affiliationName":[{"@value":"Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896322649346","@type":"Researcher","foaf:name":[{"@value":"Mihir Pendse"}],"jpcoar:affiliationName":[{"@value":"Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896322649350","@type":"Researcher","foaf:name":[{"@value":"Yuhao Wang"}],"jpcoar:affiliationName":[{"@value":"Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896322649351","@type":"Researcher","foaf:name":[{"@value":"Yun Li"}],"jpcoar:affiliationName":[{"@value":"Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896322649348","@type":"Researcher","foaf:name":[{"@value":"Kelly A. Ruhn"}],"jpcoar:affiliationName":[{"@value":"Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896322649344","@type":"Researcher","foaf:name":[{"@value":"Brian Hassell"}],"jpcoar:affiliationName":[{"@value":"Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896322649349","@type":"Researcher","foaf:name":[{"@value":"Tess Leal"}],"jpcoar:affiliationName":[{"@value":"Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896322649353","@type":"Researcher","foaf:name":[{"@value":"Sebastian E. Winter"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896322649352","@type":"Researcher","foaf:name":[{"@value":"Ramnik J. Xavier"}],"jpcoar:affiliationName":[{"@value":"Broad Institute, Cambridge, MA 02142, USA."},{"@value":"Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA."},{"@value":"Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02142, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896322649347","@type":"Researcher","foaf:name":[{"@value":"Lora V. Hooper"}],"jpcoar:affiliationName":[{"@value":"Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."},{"@value":"The Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"2017-09-08","prism:volume":"357","prism:number":"6355","prism:startingPage":"1047","prism:endingPage":"1052"},"reviewed":"false","url":[{"@id":"https://syndication.highwire.org/content/doi/10.1126/science.aal4677"},{"@id":"https://www.science.org/doi/pdf/10.1126/science.aal4677"}],"createdAt":"2017-07-27","modifiedAt":"2024-01-15","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360290617882504960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298755601246848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impaired GATE16-mediated exocytosis in exocrine tissues causes Sjögren’s syndrome-like exocrinopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360306905632379392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mast cell secretory granule fusion with amphisomes coordinates their homotypic fusion and release of exosomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584339753149824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The interaction between autophagy, Helicobacter pylori, and gut microbiota in gastric carcinogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848664409270656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impact of Autophagy of Innate Immune Cells on Inflammatory Bowel Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865814746943104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Roles of Stress Response in Autophagy Processes and Aging-Related Diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981470971533440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification and characterization of an antimicrobial peptide, lysozyme, from Suncus murinus"}]},{"@id":"https://cir.nii.ac.jp/crid/1362257544064985728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Epithelial Cells as a Transmitter of Signals From Commensal Bacteria and Host Immune Cells"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1126/science.aal4677"},{"@type":"CROSSREF","@value":"10.1080/15548627.2020.1797280_references_DOI_BvacuIuUwXiUSaiHFM2kw09NSjz"},{"@type":"CROSSREF","@value":"10.1007/s00441-019-02991-2_references_DOI_BvacuIuUwXiUSaiHFM2kw09NSjz"},{"@type":"CROSSREF","@value":"10.1007/s00018-022-04334-x_references_DOI_BvacuIuUwXiUSaiHFM2kw09NSjz"},{"@type":"CROSSREF","@value":"10.1016/j.celrep.2024.114482_references_DOI_BvacuIuUwXiUSaiHFM2kw09NSjz"},{"@type":"CROSSREF","@value":"10.1016/j.tim.2023.04.001_references_DOI_BvacuIuUwXiUSaiHFM2kw09NSjz"},{"@type":"CROSSREF","@value":"10.3390/cells8010007_references_DOI_BvacuIuUwXiUSaiHFM2kw09NSjz"},{"@type":"CROSSREF","@value":"10.3390/ijms241813804_references_DOI_BvacuIuUwXiUSaiHFM2kw09NSjz"},{"@type":"CROSSREF","@value":"10.3389/fimmu.2019.02057_references_DOI_BvacuIuUwXiUSaiHFM2kw09NSjz"}]}