{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825896338449792.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1101/gad.1973910"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1101/gad.1973910"}}],"dc:title":[{"@value":"Eph/ephrin molecules—a hub for signaling and endocytosis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>The development, homeostasis, and regeneration of complex organ systems require extensive cell–cell communication to ensure that different cells proliferate, migrate, differentiate, assemble, and function in a coordinated and timely fashion. Eph receptor tyrosine kinases and their ephrin ligands are critical regulators of cell contact-dependent signaling and patterning. Eph/ephrin binding can lead to very diverse biological readouts such as adhesion versus repulsion, or increased versus decreased motility. Accordingly, depending on cell type and context, a limited and conserved set of receptor–ligand interactions is translated into a large variety of downstream signaling processes. Recent evidence indicates that the endocytosis of Eph/ephrin molecules, together with the internalization of various associated tissue-specific effectors, might be one of the key principles responsible for such highly diverse and adaptable biological roles. Here, we summarize recent insights into Eph/ephrin signaling and endocytosis in three biological systems; i.e., the brain, intestine, and vasculature.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825896338449793","@type":"Researcher","foaf:name":[{"@value":"Mara E. Pitulescu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896338449792","@type":"Researcher","foaf:name":[{"@value":"Ralf H. Adams"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08909369"},{"@type":"EISSN","@value":"15495477"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/08909369"}],"prism:publicationName":[{"@value":"Genes & Development"}],"dc:publisher":[{"@value":"Cold Spring Harbor Laboratory"}],"prism:publicationDate":"2010-11-15","prism:volume":"24","prism:number":"22","prism:startingPage":"2480","prism:endingPage":"2492"},"reviewed":"false","url":[{"@id":"https://syndication.highwire.org/content/doi/10.1101/gad.1973910"}],"createdAt":"2010-11-15","modifiedAt":"2021-11-16","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282810831524352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"HGF-induced serine 897 phosphorylation of EphA2 regulates epithelial morphogenesis of MDCK cells in 3D culture"},{"@value":"HGF-induced serine 897 phosphorylation of EphA2 regulates 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