{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825896402038144.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/nature01984"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/nature01984.pdf"}},{"identifier":{"@type":"URI","@value":"http://www.nature.com/articles/nature01984"}},{"identifier":{"@type":"PMID","@value":"14523448"}}],"dc:title":[{"@value":"Differential regulation of EIN3 stability by glucose and ethylene signalling in plants"}],"description":[{"notation":[{"@value":"Glucose is a global regulator of growth and metabolism that is evolutionarily conserved from unicellular microorganisms to multicellular animals and plants. In photosynthetic plants, glucose shows hormone-like activities and modulates many essential processes, including embryogenesis, germination, seedling development, vegetative growth, reproduction and senescence. Genetic and phenotypic analyses of Arabidopsis mutants with glucose-insensitive (gin) and glucose-oversensitive (glo) phenotypes have identified an unexpected antagonistic interaction between glucose and the plant stress hormone ethylene. The ethylene-insensitive etr1 and ein2 mutants have glo phenotypes, whereas the constitutive ethylene signalling mutant ctr1 is allelic to gin4 (refs 4, 5). The precise molecular mechanisms underlying the complex signalling network that governs plant growth and development in response to nutrients and plant hormones are mostly unknown. Here we show that glucose enhances the degradation of ETHYLENE-INSENSITIVE3 (EIN3), a key transcriptional regulator in ethylene signalling, through the plant glucose sensor hexokinase. Ethylene, by contrast, enhances the stability of EIN3. The ein3 mutant has a glo phenotype, and overexpression of EIN3 in transgenic Arabidopsis decreases glucose sensitivity."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825896402038146","@type":"Researcher","foaf:name":[{"@value":"Shuichi Yanagisawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896402038145","@type":"Researcher","foaf:name":[{"@value":"Sang-Dong Yoo"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825896402038144","@type":"Researcher","foaf:name":[{"@value":"Jen Sheen"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00280836"},{"@type":"EISSN","@value":"14764687"}],"prism:publicationName":[{"@value":"Nature"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2003-10","prism:volume":"425","prism:number":"6957","prism:startingPage":"521","prism:endingPage":"525"},"reviewed":"false","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://www.nature.com/articles/nature01984.pdf"},{"@id":"http://www.nature.com/articles/nature01984"}],"createdAt":"2003-10-01","modifiedAt":"2023-05-18","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Arabidopsis%20Proteins","dc:title":"Arabidopsis Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Protoplasts","dc:title":"Protoplasts"},{"@id":"https://cir.nii.ac.jp/all?q=Arabidopsis","dc:title":"Arabidopsis"},{"@id":"https://cir.nii.ac.jp/all?q=Nuclear%20Proteins","dc:title":"Nuclear Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Ethylenes","dc:title":"Ethylenes"},{"@id":"https://cir.nii.ac.jp/all?q=Plants,%20Genetically%20Modified","dc:title":"Plants, Genetically Modified"},{"@id":"https://cir.nii.ac.jp/all?q=Zea%20mays","dc:title":"Zea mays"},{"@id":"https://cir.nii.ac.jp/all?q=DNA-Binding%20Proteins","dc:title":"DNA-Binding Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Glucose","dc:title":"Glucose"},{"@id":"https://cir.nii.ac.jp/all?q=Phenotype","dc:title":"Phenotype"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Regulation,%20Plant","dc:title":"Gene Expression Regulation, Plant"},{"@id":"https://cir.nii.ac.jp/all?q=Mutation","dc:title":"Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Processing,%20Post-Translational","dc:title":"Protein Processing, Post-Translational"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"},{"@id":"https://cir.nii.ac.jp/all?q=Transcription%20Factors","dc:title":"Transcription Factors"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202661779584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Evidence for lateral 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provascular cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285709755414016","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ethylene Signaling Pathway and MAPK Cascades Are Required for AAL Toxin–Induced Programmed Cell Death"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183206588416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Proteomic Characterization of the Greening Process in Rice Seedlings Using the MS Spectral Intensity-based Label Free Method"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567189912288000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The evolutionary events necessary for the emergence of symbiotic nitrogen fixation in legumes may involve a loss of nitrate responsiveness of the NIN transcription 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