Characterization of a Canine Homolog of Human Aichivirus

DOI Web Site 6 Citations
  • Peter Simmonds
    Centre for Immunology, Infection, and Evolution, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
  • Amit Kapoor
    Center for Infection and Immunity, Columbia University, New York, New York 10032
  • Natasha Qaisar
    Center for Infection and Immunity, Columbia University, New York, New York 10032
  • Edward J. Dubovi
    College of Veterinary Medicine, Cornell University, Ithaca, New York 14853
  • Jose A. Henriquez
    Center for Infection and Immunity, Columbia University, New York, New York 10032
  • Jan Medina
    Center for Infection and Immunity, Columbia University, New York, New York 10032
  • Shelly Shields
    Pfizer Veterinary Medicine Research and Development, New York, New York 10017
  • W. Ian Lipkin
    Center for Infection and Immunity, Columbia University, New York, New York 10032

Bibliographic Information

Published
2011-11
Rights Information
  • https://journals.asm.org/non-commercial-tdm-license
DOI
  • 10.1128/jvi.05317-11
Publisher
American Society for Microbiology

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Description

<jats:title>ABSTRACT</jats:title> <jats:p>Many of our fatal “civilization” infectious diseases have arisen from domesticated animals. Although picornaviruses infect most mammals, infection of a companion animal is not known. Here we describe the identification and genomic characterization of the first canine picornavirus. Canine kobuvirus (CKoV), identified in stool samples from dogs with diarrhea, has a genomic organization typical of a picornavirus and encodes a 2,469-amino-acid polyprotein flanked by 5′ and 3′ untranslated regions. Comparative phylogenetic analysis using various structural and nonstructural proteins of CKoV confirmed it as the animal virus homolog most closely related to human Aichivirus (AiV). Bayesian Markov chain Monte Carlo analysis suggests a mean recent divergence time of CKoV and AiV within the past 20 to 50 years, well after the domestication of canines. The discovery of CKoV provides new insights into the origin and evolution of AiV and the species specificity and pathogenesis of kobuviruses.</jats:p>

Journal

  • Journal of Virology

    Journal of Virology 85 (21), 11520-11525, 2011-11

    American Society for Microbiology

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