{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363107370565217536.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.aax6089"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1126/science.aax6089"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.aax6089"}}],"dc:title":[{"@value":"Golgi-derived PI\n            <b>(</b>\n            4\n            <b>)</b>\n            P-containing vesicles drive late steps of mitochondrial division"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>PI(4)P regulates mitochondrial fission</jats:title>\n          <jats:p>\n            Mitochondria are dynamic intracellular organelles, the shape and number of which are regulated by various cell-signaling pathways. Mitochondrial division is driven by the recruitment of a constricting guanosine triphosphatase protein at sites of contact with the endoplasmic reticulum, but other factors, including lysosomes, are also involved. Nagashima\n            <jats:italic>et al.</jats:italic>\n            now document an essential role for Golgi-derived vesicles bearing a specific lipid—phosphatidylinositol 4-phosphate, or PI(4)P—in the final steps of mitochondrial division. Disruption of PI(4)P production results in mitochondrial morphological defects indicative of an inability to complete fission.\n          </jats:p>\n          <jats:p>\n            <jats:italic>Science</jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6484\" page=\"1366\" related-article-type=\"in-this-issue\" vol=\"367\" xlink:href=\"10.1126/science.aax6089\">1366</jats:related-article>\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383107370565217543","@type":"Researcher","foaf:name":[{"@value":"Luis-Carlos Tábara"}],"jpcoar:affiliationName":[{"@value":"Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1383107370565217408","@type":"Researcher","foaf:name":[{"@value":"Shun Nagashima"}],"jpcoar:affiliationName":[{"@value":"Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1383107370565217537","@type":"Researcher","foaf:name":[{"@value":"Lisa Tilokani"}],"jpcoar:affiliationName":[{"@value":"Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1383107370565217542","@type":"Researcher","foaf:name":[{"@value":"Joe H. Pogson"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3B 2B4, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1383107370565217538","@type":"Researcher","foaf:name":[{"@value":"Heidi M. McBride"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3B 2B4, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1383107370565217539","@type":"Researcher","foaf:name":[{"@value":"Rodolfo Zunino"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3B 2B4, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1383107370565217536","@type":"Researcher","foaf:name":[{"@value":"Vincent Paupe"}],"jpcoar:affiliationName":[{"@value":"Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1383107370565217540","@type":"Researcher","foaf:name":[{"@value":"Hanish Anand"}],"jpcoar:affiliationName":[{"@value":"Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1383107370565217541","@type":"Researcher","foaf:name":[{"@value":"Julien Prudent"}],"jpcoar:affiliationName":[{"@value":"Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0XY, UK."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"2020-03-20","prism:volume":"367","prism:number":"6484","prism:startingPage":"1366","prism:endingPage":"1371"},"reviewed":"false","url":[{"@id":"https://syndication.highwire.org/content/doi/10.1126/science.aax6089"},{"@id":"https://www.science.org/doi/pdf/10.1126/science.aax6089"}],"createdAt":"2020-03-19","modifiedAt":"2024-01-15","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360017280652197120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ubiquitin-mediated mitochondrial regulation by MITOL/MARCHF5 at a glance"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617885010432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757180872192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cancer metabolism within tumor microenvironments"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584341815408384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mitochondrial dynamics as a pathobiological mediator of clonal myeloid disorders"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593797598208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Functions of Oxysterol-Binding Proteins at Membrane Contact Sites and Their Control by Phosphoinositide Metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861704768217984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Metabolic adaptations of cancer in extreme tumor microenvironments"}]},{"@id":"https://cir.nii.ac.jp/crid/1360869856056650368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Etomoxir suppresses the expression of PPARγ2 and inhibits the thermogenic gene induction of brown adipocytes through pathways other than β-oxidation inhibition"}]},{"@id":"https://cir.nii.ac.jp/crid/1520292251376350208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1126/science.aax6089"},{"@type":"CROSSREF","@value":"10.1093/jb/mvac092_references_DOI_To7FsCA2W55AhJgj1Tiz4KaTPxT"},{"@type":"CROSSREF","@value":"10.1093/cvr/cvab034_references_DOI_To7FsCA2W55AhJgj1Tiz4KaTPxT"},{"@type":"CROSSREF","@value":"10.1016/j.bbagen.2023.130330_references_DOI_To7FsCA2W55AhJgj1Tiz4KaTPxT"},{"@type":"CROSSREF","@value":"10.1093/jb/mvab153_references_DOI_To7FsCA2W55AhJgj1Tiz4KaTPxT"},{"@type":"CROSSREF","@value":"10.1111/cas.15810_references_DOI_To7FsCA2W55AhJgj1Tiz4KaTPxT"},{"@type":"CROSSREF","@value":"10.3389/fcell.2021.664788_references_DOI_To7FsCA2W55AhJgj1Tiz4KaTPxT"},{"@type":"CROSSREF","@value":"10.1111/cas.15722_references_DOI_To7FsCA2W55AhJgj1Tiz4KaTPxT"},{"@type":"CROSSREF","@value":"10.1093/jb/mvae092_references_DOI_To7FsCA2W55AhJgj1Tiz4KaTPxT"}]}