Selective Formation of a Linear-Shaped Bundle of Microtubules

DOI Web Site PubMed 13 Citations
  • Ryuzo Kawamura
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan
  • Akira Kakugo
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan
  • Yoshihito Osada
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan
  • Jian Ping Gong
    Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan

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Description

By using rigid microtubules (MTs) prepared by polymerization with guanylyl-(alpha, beta)-methylene-diphosphonate GMPCPP, giant straight-shaped MT bundles were selectively obtained through a dynamic self-assembly process. We demonstrate the effect of the rigidity on the shape and motility of MT bundle composed of GMPCPP-polymerized MTs (GMPCPP-MTs) compared with control MTs that were polymerized with GTP and stabilized with paclitaxel.

Journal

  • Langmuir

    Langmuir 26 (1), 533-537, 2009-10-08

    American Chemical Society (ACS)

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