{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388843430201600.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/s0014-2999(99)00181-8"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0014299999001818?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0014299999001818?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"10374711"}}],"dc:title":[{"@value":"Differential involvement of μ-opioid receptor subtypes in endomorphin-1- and -2-induced antinociception"}],"description":[{"notation":[{"@value":"We investigated the role of mu-opioid receptor subtypes in both endomorphin-1 and endomorphin-2 induced antinociception in mice using supraspinally mediated behavior. With tail pressure as a mechanical noxious stimulus, both intracerebroventricularly (i.c.v.) and intrathecally (i.t.) injected-endomorphins produced potent and significant antinociceptive activity. Antinociception induced by i.t. and i.c.v. injection of endomorphin-1 was not reversed by pretreatment with a selective mu1-opioid receptor antagonist, naloxonazine (35 mg/kg, s.c.). By contrast, antinociception induced by i.t. and i.c.v. endomorphin-2 was significantly decreased by mu1-opioid receptor antagonist. Antinociception of both i.t. and i.c.v. endomorphin-1 and -2 was completely reversed by pretreatment with beta-funaltrexamine (40 mg/kg, s.c.). The results indicate that endomorphins may produce antinociception through the distinct mu1 and mu2 subtypes of mu-opioid receptor."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388843430201728","@type":"Researcher","foaf:name":[{"@value":"Shinobu Sakurada"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843430201601","@type":"Researcher","foaf:name":[{"@value":"James E Zadina"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843430201731","@type":"Researcher","foaf:name":[{"@value":"Abba J Kastin"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843430201730","@type":"Researcher","foaf:name":[{"@value":"Sou Katsuyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843430201600","@type":"Researcher","foaf:name":[{"@value":"Tsutomu Fujimura"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843430201602","@type":"Researcher","foaf:name":[{"@value":"Kimie Murayama"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843430201729","@type":"Researcher","foaf:name":[{"@value":"Masayuki Yuki"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843430201603","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Ueda"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843430201732","@type":"Researcher","foaf:name":[{"@value":"Tsukasa Sakurada"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00142999"}],"prism:publicationName":[{"@value":"European Journal of Pharmacology"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"1999-05","prism:volume":"372","prism:number":"1","prism:startingPage":"25","prism:endingPage":"30"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0014299999001818?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0014299999001818?httpAccept=text/plain"}],"createdAt":"2002-07-25","modifiedAt":"2019-04-30","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Time%20Factors","dc:title":"Time Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Dose-Response%20Relationship,%20Drug","dc:title":"Dose-Response Relationship, Drug"},{"@id":"https://cir.nii.ac.jp/all?q=Naloxone","dc:title":"Naloxone"},{"@id":"https://cir.nii.ac.jp/all?q=Narcotic%20Antagonists","dc:title":"Narcotic Antagonists"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Opioid,%20mu","dc:title":"Receptors, Opioid, mu"},{"@id":"https://cir.nii.ac.jp/all?q=Nociceptors","dc:title":"Nociceptors"},{"@id":"https://cir.nii.ac.jp/all?q=Pain","dc:title":"Pain"},{"@id":"https://cir.nii.ac.jp/all?q=Enkephalins","dc:title":"Enkephalins"},{"@id":"https://cir.nii.ac.jp/all?q=Enkephalin,%20Ala(2)-MePhe(4)-Gly(5)-","dc:title":"Enkephalin, Ala(2)-MePhe(4)-Gly(5)-"},{"@id":"https://cir.nii.ac.jp/all?q=Naltrexone","dc:title":"Naltrexone"},{"@id":"https://cir.nii.ac.jp/all?q=Analgesics,%20Opioid","dc:title":"Analgesics, Opioid"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Oligopeptides","dc:title":"Oligopeptides"},{"@id":"https://cir.nii.ac.jp/all?q=Injections,%20Spinal","dc:title":"Injections, Spinal"},{"@id":"https://cir.nii.ac.jp/all?q=Injections,%20Intraventricular","dc:title":"Injections, Intraventricular"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002215878620928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"New vistas in opioid control of pain"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707402731392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Involvement of spinal release of α-neo-endorphin on the antinociceptive effect of TAPA"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565164519264384","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Involvement of peripheral cannabinoid and opioid receptors in<scp>β</scp>‐caryophyllene‐induced antinociception"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641044164992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Involvement of multiple μ-opioid receptor subtypes on the presynaptic or postsynaptic inhibition of spinal pain transmission"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204285930624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Recent Advances in the Search for the .MU.-Opioidergic System. Morphological Studies of the Endomorphinergic Neurons in the Central Nervous System."},{"@value":"Recent Advances in the Search for the N-Opioidergic System: Morphological Studies of the Endomorphinergic Neurons in the Central Nervous System"},{"@value":"Recent advances in the search for the μ-opioidergic system: morphological studies of the endomorphinergic neurons in the central nervous system"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204285931904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Recent Advances in the Search for the μ-Opioidergic System"},{"@language":"ja-Kana","@value":"Antinociceptive Properties of Endomorphin 1 and Endomorphin 2 in the Mouse"},{"@value":"Recent Advances in the Search for the μ-Opioidergic System: The Antinociceptive Properties of Endomorphin-1 and Endomorphin-2 in the Mouse"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206128924160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"エンドモルフィンの代謝に基づく鎮痛薬の開発"},{"@language":"en","@value":"Development of a New Analgesic Based on Metabolism of Endomorphin, an Endogenous Opioid Peptide"},{"@language":"ja-Kana","@value":"エンドモルフィン ノ タイシャ ニ モトヅク チンツウヤク ノ カイハツ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679262670464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Recent Advances in the Search for the .MU.-Opioidergic System. Differential Antinociceptive Effects Induced by Intrathecally-Administered Endomorphin-1 and Endomorphin-2 in Mice."},{"@value":"Recent Advances in the Search for the μ-Opioidergic System: Differential Antinociceptive Effects Induced by Intrathecally-Administered Endomorphin-1 and Endomorphin-2 in Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680183544320","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Central Injection of Endomorphin-2, but not Endomorphin-1, Increases Food Intake in Chicks via .MU.1-opioid Receptors"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/s0014-2999(99)00181-8"},{"@type":"OPENAIRE","@value":"doi_dedup___::0cbc5075b6416e0791ce03427e4f4935"},{"@type":"CROSSREF","@value":"10.1254/jjp.89.221_references_DOI_GVoxVY2ZCjoWNvJxsWKPEZ5itRy"},{"@type":"CROSSREF","@value":"10.1254/jjp.89.216_references_DOI_GVoxVY2ZCjoWNvJxsWKPEZ5itRy"},{"@type":"CROSSREF","@value":"10.1002/j.1532-2149.2012.00242.x_references_DOI_GVoxVY2ZCjoWNvJxsWKPEZ5itRy"},{"@type":"CROSSREF","@value":"10.2141/jpsa.44.205_references_DOI_GVoxVY2ZCjoWNvJxsWKPEZ5itRy"},{"@type":"CROSSREF","@value":"10.1248/yakushi.124.549_references_DOI_GVoxVY2ZCjoWNvJxsWKPEZ5itRy"},{"@type":"CROSSREF","@value":"10.1016/j.peptides.2013.10.003_references_DOI_GVoxVY2ZCjoWNvJxsWKPEZ5itRy"},{"@type":"CROSSREF","@value":"10.1254/jjp.89.209_references_DOI_GVoxVY2ZCjoWNvJxsWKPEZ5itRy"},{"@type":"CROSSREF","@value":"10.1016/j.coph.2011.10.020_references_DOI_GVoxVY2ZCjoWNvJxsWKPEZ5itRy"},{"@type":"CROSSREF","@value":"10.1016/j.peptides.2013.10.012_references_DOI_GVoxVY2ZCjoWNvJxsWKPEZ5itRy"}]}