{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388843674893824.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/01.atv.18.5.768"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/01.ATV.18.5.768"}}],"dc:title":[{"@value":"Plasma Viscosity and the Risk of Coronary Heart Disease"}],"dcterms:alternative":[{"@value":"Results From the MONICA-Augsburg Cohort Study, 1984 to 1992"}],"description":[{"type":"abstract","notation":[{"@value":"\n Abstract\n —Plasma viscosity is determined by various macromolecules, eg, fibrinogen, immunoglobulins, and lipoproteins. It may therefore reflect several aspects involved in cardiovascular diseases, including the effects of classic risk factors, hemostatic disturbances, and inflammation. We examined the association of plasma viscosity with the incidence of a first major coronary heart disease event (CHD; fatal and nonfatal myocardial infarction and cardiac death; n=50) in 933 men aged 45 to 64 years of the MONICA project of Augsburg, Germany. The incidence rate was 7.23 per 1000 person-years (95% confidence interval [CI], 5.37 to 9.53), and the subjects were followed up for 8 years. All suspected cases of an incident CHD event were classified according to the MONICA protocol. There was a positive and statistically significant unadjusted relationship between plasma viscosity and the incidence of CHD. The relative risk of CHD events associated with a 1-SD increase in plasma viscosity (0.070 mPa · s) was 1.60 (95% CI, 1.25 to 2.03). After adjustment for age, total cholesterol, high density lipoprotein cholesterol, smoking, blood pressure, and body mass index, the relative risk was reduced only moderately (1.42; 95% CI, 1.09 to 1.86). The relative risk of CHD events for men in the highest quintile of the plasma viscosity distribution in comparison with the lowest quintile was 3.31 (95% CI, 1.19 to 9.25) after adjustment for the aforementioned variables. A large proportion of events (40%) occurred among men in the highest quintile. These findings suggest that plasma viscosity may have considerable potential to identify subjects at risk for CHD events.\n "}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388843674893825","@type":"Researcher","foaf:name":[{"@value":"Wolfgang Koenig"}],"jpcoar:affiliationName":[{"@value":"From the Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Ulm, Germany (W.K.); the GSF National Research Center for Environment and Health, MEDIS Institute (M.S.) and Institute of Epidemiology (B.F., A.D., H.L.), Neuherberg, Germany; and the Postgraduate Medical School (E.E.), University of Exeter, Exeter, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843674893827","@type":"Researcher","foaf:name":[{"@value":"Malte Sund"}],"jpcoar:affiliationName":[{"@value":"From the Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Ulm, Germany (W.K.); the GSF National Research Center for Environment and Health, MEDIS Institute (M.S.) and Institute of Epidemiology (B.F., A.D., H.L.), Neuherberg, Germany; and the Postgraduate Medical School (E.E.), University of Exeter, Exeter, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843674893829","@type":"Researcher","foaf:name":[{"@value":"Birgit Filipiak"}],"jpcoar:affiliationName":[{"@value":"From the Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Ulm, Germany (W.K.); the GSF National Research Center for Environment and Health, MEDIS Institute (M.S.) and Institute of Epidemiology (B.F., A.D., H.L.), Neuherberg, Germany; and the Postgraduate Medical School (E.E.), University of Exeter, Exeter, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843674893826","@type":"Researcher","foaf:name":[{"@value":"Angela Döring"}],"jpcoar:affiliationName":[{"@value":"From the Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Ulm, Germany (W.K.); the GSF National Research Center for Environment and Health, MEDIS Institute (M.S.) and Institute of Epidemiology (B.F., A.D., H.L.), Neuherberg, Germany; and the Postgraduate Medical School (E.E.), University of Exeter, Exeter, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843674893828","@type":"Researcher","foaf:name":[{"@value":"Hannelore Löwel"}],"jpcoar:affiliationName":[{"@value":"From the Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Ulm, Germany (W.K.); the GSF National Research Center for Environment and Health, MEDIS Institute (M.S.) and Institute of Epidemiology (B.F., A.D., H.L.), Neuherberg, Germany; and the Postgraduate Medical School (E.E.), University of Exeter, Exeter, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843674893824","@type":"Researcher","foaf:name":[{"@value":"Edzard Ernst"}],"jpcoar:affiliationName":[{"@value":"From the Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Ulm, Germany (W.K.); the GSF National Research Center for Environment and Health, MEDIS Institute (M.S.) and Institute of Epidemiology (B.F., A.D., H.L.), Neuherberg, Germany; and the Postgraduate Medical School (E.E.), University of Exeter, Exeter, UK."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10795642"},{"@type":"EISSN","@value":"15244636"}],"prism:publicationName":[{"@value":"Arteriosclerosis, Thrombosis, and Vascular Biology"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"1998-05","prism:volume":"18","prism:number":"5","prism:startingPage":"768","prism:endingPage":"772"},"reviewed":"false","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/01.ATV.18.5.768"}],"createdAt":"2011-06-17","modifiedAt":"2022-03-17","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004239350356736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impaired blood rheology is associated with endothelial dysfunction in patients with coronary risk factors"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656474933248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Estimation of viscosity from passage time of liquids flowing through a microchannel array"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658026099584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Water intake from foods and beverages and risk of mortality from CVD: the Japan Collaborative Cohort (JACC) Study"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1161/01.atv.18.5.768"},{"@type":"CROSSREF","@value":"10.3233/ch-151960_references_DOI_XZy4oKelO4mpRcdtlBQPj4otsgp"},{"@type":"CROSSREF","@value":"10.1007/s12573-012-0048-5_references_DOI_XZy4oKelO4mpRcdtlBQPj4otsgp"},{"@type":"CROSSREF","@value":"10.1017/s1368980018001386_references_DOI_XZy4oKelO4mpRcdtlBQPj4otsgp"}]}