{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388843805515008.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/rmv.1776"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Frmv.1776"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/rmv.1776"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/rmv.1776"}}],"dc:title":[{"@value":"Systematic review of severe fever with thrombocytopenia syndrome:virology, epidemiology, and clinical characteristics"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>SUMMARY</jats:title><jats:p>Severe fever with thrombocytopenia syndrome (SFTS) was firstly discovered in China in 2010, followed by several reports from many other countries worldwide. SFTS virus (SFTSV) has been identified as the causative agent of the disease and has been recognized as a public health threat. This novel <jats:italic>Bunyavirus</jats:italic> belongs to the <jats:italic>Phlebovirus</jats:italic> genus in the family <jats:italic>Bunyaviridae</jats:italic>. This review also describes the different aspects of virology, pathogenesis, epidemiology, and clinical symptoms on the basis of the published article surveillance data and phylogenetic analyses of viral sequences of large, medium, and small segments retrieved from database using <jats:sc>mega</jats:sc> 5.05, <jats:sc>simplot</jats:sc> 3.5.1, <jats:sc>network</jats:sc> 4.611, and <jats:sc>epi</jats:sc> information system 3.5.3 software. SFTS presents with fever, thrombocytopenia, leukocytopenia, and considerable changes in several serum biomarkers. The disease has 10 ~ 15% mortality rate, commonly because of multiorgan dysfunction. SFTSV is mainly reported in the rural areas of Central and North‐Eastern China, with seasonal occurrence from May to September, mainly targeting those of ≥50 years of age. A wide range of domesticated animals, including sheep, goats, cattle, pigs, dogs, and chickens have been proven seropositive for SFTSV. Ticks, especially <jats:italic>Haemaphysalis longicornis</jats:italic>, are suspected to be the potential vector, which have a broad animal host range in the world. More studies are needed to elucidate the vector–animal–human ecological cycle, the pathogenic mechanisms in high level animal models and vaccine development. © 2013 The Authors. Reviews in Medical Virology published by John Wiley & Sons, Ltd.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388843805515015","@type":"Researcher","foaf:name":[{"@value":"Shelan Liu"}],"jpcoar:affiliationName":[{"@value":"Department of Infectious Diseases Zhejiang Provincial Centre for Disease Control and Prevention  Hangzhou Zhejiang Province China"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843805515014","@type":"Researcher","foaf:name":[{"@value":"Chengliang Chai"}],"jpcoar:affiliationName":[{"@value":"Department of Infectious Diseases Zhejiang Provincial Centre for Disease Control and Prevention  Hangzhou Zhejiang Province China"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843805515010","@type":"Researcher","foaf:name":[{"@value":"Chengmin Wang"}],"jpcoar:affiliationName":[{"@value":"National Research Center for Wildlife Born Diseases, Institute of Zoology Chinese Academy of Sciences  Beijing China"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843805515012","@type":"Researcher","foaf:name":[{"@value":"Said Amer"}],"jpcoar:affiliationName":[{"@value":"National Research Center for Wildlife Born Diseases, Institute of Zoology Chinese Academy of Sciences  Beijing China"},{"@value":"Department of Zoology, Faculty of Science Kafr El‐Sheikh University  Kafr El‐Sheikh Egypt"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843805515011","@type":"Researcher","foaf:name":[{"@value":"Huakun Lv"}],"jpcoar:affiliationName":[{"@value":"Department of Infectious Diseases Zhejiang Provincial Centre for Disease Control and Prevention  Hangzhou Zhejiang Province China"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843805515013","@type":"Researcher","foaf:name":[{"@value":"Hongxuan He"}],"jpcoar:affiliationName":[{"@value":"National Research Center for Wildlife Born Diseases, Institute of Zoology Chinese Academy of Sciences  Beijing China"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843805515009","@type":"Researcher","foaf:name":[{"@value":"Jimin Sun"}],"jpcoar:affiliationName":[{"@value":"Department of Infectious Diseases Zhejiang Provincial Centre for Disease Control and Prevention  Hangzhou Zhejiang Province China"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388843805515008","@type":"Researcher","foaf:name":[{"@value":"Junfen Lin"}],"jpcoar:affiliationName":[{"@value":"Department of Public Health Surveillance and Advisory Zhejiang Provincial Centre for Disease Control and Prevention  Hangzhou Zhejiang Province China"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10529276"},{"@type":"EISSN","@value":"10991654"}],"prism:publicationName":[{"@value":"Reviews in Medical Virology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2013-12-06","prism:volume":"24","prism:number":"2","prism:startingPage":"90","prism:endingPage":"102"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by-nc-nd/3.0/"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Frmv.1776"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/rmv.1776"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/rmv.1776"}],"createdAt":"2013-12-06","modifiedAt":"2023-10-05","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050022708921660800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Steroid pulse therapy in patients with encephalopathy associated with severe fever with thrombocytopenia syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1050850247228984576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Seroepidemiological evidence of severe fever with thrombocytopenia syndrome virus infections in wild boars in Nagasaki, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1360022305560673408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A highly attenuated vaccinia virus strain LC16m8-based vaccine for severe fever with thrombocytopenia syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360022305560686080","@type":"Article","resourceType":"preprint","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Development of a reverse transcription polymerase chain reaction for the detection of severe fever with thrombocytopenia syndrome virus from suspected infected animals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711817640704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evaluation and comparison of the potential of two ferritins as anti-tick vaccines against Haemaphysalis longicornis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166147920640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Therapeutic effect of post-exposure treatment with antiserum on severe fever with thrombocytopenia syndrome (SFTS) in a mouse model of SFTS virus infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182236942720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Seroprevalence of severe fever with thrombocytopenia syndrome (SFTS) virus antibodies in humans and animals in Ehime prefecture, Japan, an endemic region of SFTS"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567188227477120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"18F-FDG PET imaging for identifying the dynamics of intestinal disease caused by SFTSV infection in a mouse model"}]},{"@id":"https://cir.nii.ac.jp/crid/1360568468328716288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Severe Fever with Thrombocytopenia Syndrome Phlebovirus causes lethal viral hemorrhagic fever in cats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092642466944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Diagnostic system for the detection of severe fever with thrombocytopenia syndrome virus RNA from suspected infected animals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118840916224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Propagation of Activated B Cells by In Vitro Severe Fever With Thrombocytopenia Syndrome Virus Infection of Human Peripheral Blood Mononuclear Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584339749715456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Characterization of antibodies targeting severe fever with thrombocytopenia syndrome virus glycoprotein Gc"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588381045682048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Characterization and arbovirus susceptibility of cultured CERNI cells derived from sika deer (Cervus nippon)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848661764157312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Combination effects of ribavirin and interferons on severe fever with thrombocytopenia syndrome virus infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593670744192","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Severe Fever with Thrombocytopenia Syndrome in Cats and Its Prevalence among Veterinarian Staff Members in Nagasaki, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1361131421495209984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204875507200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"SFTS : Severe fever with thrombocytopenia syndrome"},{"@language":"ja","@value":"重症熱性血小板減少症候群"},{"@value":"キーワード 重症熱性血小板減少症候群"},{"@language":"ja-Kana","@value":"キーワード ジュウショウ ネッセイ ケッショウバン ゲンショウ ショウコウグン"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204875712640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Fatal Severe Fever with Thrombocytopenia Syndrome: An Autopsy Case Report"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205078308736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"重症熱性血小板減少症候群（SFTS）とSFTSウイルス"},{"@language":"en","@value":"Severe fever with thrombocytopenia syndrome (SFTS) and SFTS virus"},{"@language":"ja-Kana","@value":"ジュウショウ ネッセイ ケッショウバン ゲンショウ ショウコウグン(SFTS)ト SFTS ウイルス"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206241112320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Presence of Antibodies against Severe Fever with Thrombocytopenia Syndrome Virus in Non-Endemic Areas of China"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679811307264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"重症熱性血小板減少症候群（SFTS）様の症状を呈した患者における抗SFTSウイルス抗体の検討"},{"@language":"en","@value":"Analysis of Antibodies against Severe Fever with Thrombocytopenia Syndrome（SFTS）Virus in Patients with SFTS-like Symptoms"},{"@language":"ja-Kana","@value":"ジュウショウ ネッセイ ケッショウバン ゲンショウ ショウコウグン SFTS ヨウ ノ ショウジョウ オ テイシタ カンジャ ニオケル コウ SFTS ウイルス コウタイ ノ ケントウ"},{"@language":"ja-Kana","@value":"ジュウショウ ネッセイ ケッショウバン ゲンショウ ショウコウグン(SFTS)サマ ノ ショウジョウ オ テイシタ カンジャ ニ オケル コウSFTS ウイルス コウタイ ノ ケントウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679812493824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"重症熱性血小板減少症候群（SFTS）"},{"@language":"en","@value":"Severe Fever with Thrombocytopenia Syndrome（SFTS）"},{"@language":"ja-Kana","@value":"ジュウショウ ネッセイ ケッショウバン ゲンショウ ショウコウグン SFTS ミニ レビュー : コニシショウ ジュショウシャ"},{"@value":"小西賞受賞者 重症熱性血小板減少症候群(SFTS)"},{"@language":"ja-Kana","@value":"コニシショウ ジュショウシャ ジュウショウ ネッセイ ケッショウバン ゲンショウ ショウコウグン(SFTS)"}]},{"@id":"https://cir.nii.ac.jp/crid/1390297924422065920","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Severe fever with thrombocytopenia syndrome of cats"},{"@language":"ja","@value":"ネコにおける重症熱性血小板減少症候群"},{"@language":"ja-Kana","@value":"ネコ ニ オケル ジュウショウ ネッセイ ケッショウバン ゲンショウ ショウコウグン"}]},{"@id":"https://cir.nii.ac.jp/crid/1390564237990733696","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"「一目瞭然！目で診る症例」問題・解答"},{"@language":"en","@value":"Series: Diagnosis at a Glance"}]},{"@id":"https://cir.nii.ac.jp/crid/1390573726308614272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Acute Myocarditis with Severe Fever and Thrombocytopenia Syndrome"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/rmv.1776"},{"@type":"CROSSREF","@value":"10.1016/j.jiac.2018.06.007_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.18632/oncotarget.6645_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.2222/jsv.69.169_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.1101/2020.08.06.239368_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.1101/2020.08.24.264853_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.1186/s13071-014-0482-x_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.55.5262_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.2342/ymj.63.257_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.7018-21_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.1038/s41598-019-48317-8_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.4044/joma.126.65_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.2342/ymj.65.31_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0238671_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.1093/infdis/jiab343_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.1007/s00705-024-05968-x_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.1007/s11626-024-00933-z_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.1186/s12985-015-0412-3_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.1186/s41182-016-0009-6_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.1371/journal.ppat.1008859_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.2169/naika.106.1221_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.3390/v13061142_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.1172/jci129171_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.2222/jsv.65.7_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.7883/yoken.jjid.2016.214_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.1016/j.jiac.2017.11.004_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"},{"@type":"CROSSREF","@value":"10.1016/j.virol.2015.03.010_references_DOI_BcFP5KGr18K44KwvB0oYlxQdau6"}]}