{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388844094937728.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.4049/jimmunol.181.10.6810"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/jimmunol/article-pdf/181/10/6810/62580243/8070.pdf"}}],"dc:title":[{"@value":"Caspase 6 Regulates B Cell Activation and Differentiation into Plasma Cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>Caspase (Casp) family proteases regulate not only lymphocyte apoptosis but also lymphocyte activation and development. In this study, we show that Casp6 regulates B cell activation and differentiation into plasma cells by modifying cell cycle entry. B cells from Casp6 knockout (Casp6 KO) mice examined ex vivo have more cells in G1 than wild-type B cells, and mitogen-induced G1 entry of Casp6 KO B cells is much faster than that of wild-type B cells. Even so, S phase entry and proliferation are not increased in Casp6 KO B cells. Rather than proliferating, activated Casp6 KO B cells preferentially differentiate into syndecan-1+ plasma cells and produce Abs. In Casp6 KO mice compared with WT mice, serum levels of IgG1, IgG2a, and IgG2b are increased and Ag-specific Ab responses are also enhanced along with increased percentages of syndecan-1+ plasma cells. Casp6 may regulate both B cell activation and differentiation by modifying requirements for G0 B cells to enter G1.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388844094937728","@type":"Researcher","foaf:name":[{"@value":"Chie Watanabe"}],"jpcoar:affiliationName":[{"@value":"Department of Immunology"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388844094937732","@type":"Researcher","foaf:name":[{"@value":"Geraldine L. Shu"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, University of Washington , Seattle, WA 98195"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388844094937729","@type":"Researcher","foaf:name":[{"@value":"Timothy S. Zheng"}],"jpcoar:affiliationName":[{"@value":"Department of Immunobiology, Yale University of School of Medicine , New Haven, CT 06520"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388844094937730","@type":"Researcher","foaf:name":[{"@value":"Richard A. Flavell"}],"jpcoar:affiliationName":[{"@value":"Department of Immunobiology, Yale University of School of Medicine , New Haven, CT 06520"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388844094937731","@type":"Researcher","foaf:name":[{"@value":"Edward A. Clark"}],"jpcoar:affiliationName":[{"@value":"Department of Immunology"},{"@value":"Department of Microbiology, University of Washington , Seattle, WA 98195"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"15506606"},{"@type":"PISSN","@value":"00221767"}],"prism:publicationName":[{"@value":"The Journal of Immunology"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2008-11","prism:volume":"181","prism:number":"10","prism:startingPage":"6810","prism:endingPage":"6819"},"reviewed":"false","dc:rights":["https://academic.oup.com/pages/standard-publication-reuse-rights"],"url":[{"@id":"https://academic.oup.com/jimmunol/article-pdf/181/10/6810/62580243/8070.pdf"}],"createdAt":"2014-04-18","modifiedAt":"2026-01-28","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360846645842293248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neutrophils Activate Alveolar Macrophages by Producing Caspase-6–Mediated Cleavage of IL-1 Receptor-Associated Kinase-M"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.4049/jimmunol.181.10.6810"},{"@type":"CROSSREF","@value":"10.4049/jimmunol.1001906_references_DOI_AP0islIol96KrVbFk8n2apqHfhv"}]}