{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388844524852352.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/asia.200700327"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fasia.200700327"}},{"identifier":{"@type":"URI","@value":"https://aces.onlinelibrary.wiley.com/doi/pdf/10.1002/asia.200700327"}}],"dc:title":[{"@value":"The Catalytic Acylcyanation of Imines"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The catalytic acylcyanation of aldimines with acylcyanides and a direct three‐component variant involving the generation of an imine in situ have been developed. Furthermore, a highly enantioselective version has been established, culminating in the first organocatalytic asymmetric three‐component Strecker reaction. Jacobsen thiourea catalysts were found to catalyze the reaction with excellent enantioselectivities, whereas binol phosphates (binol=1,1′‐bi‐2,2′‐naphthol) proved to be catalytically active but only modestly enantioselective. A large number of different substrates could be used in the processes described, thus illustrating the potential of our reaction for the generation of diversity within the attractive α‐amino carbonyl framework. Furthermore, a novel cyclic amidine was obtained from the reaction of acetyl cyanide with ketimines.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388844524852352","@type":"Researcher","foaf:name":[{"@value":"Subhas Chandra Pan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388844524852353","@type":"Researcher","foaf:name":[{"@value":"Benjamin List"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"18614728"},{"@type":"EISSN","@value":"1861471X"}],"prism:publicationName":[{"@value":"Chemistry – An Asian Journal"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2008-01-29","prism:volume":"3","prism:number":"2","prism:startingPage":"430","prism:endingPage":"437"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fasia.200700327"},{"@id":"https://aces.onlinelibrary.wiley.com/doi/pdf/10.1002/asia.200700327"}],"createdAt":"2008-01-18","modifiedAt":"2025-10-08","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050007902928100352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Reusable Silica-Supported Ammonium BINSate Catalysts for Enantio- and Diastereoselective Friedel–Crafts-Type Double Aminoalkylation of N-Alkylpyrroles with Aldimines"},{"@value":"Reusable Silica‐Supported Ammonium BINSate Catalysts for Enantio‐ and Diastereoselective Friedel–Crafts‐Type Double Aminoalkylation of <i>N</i>‐Alkylpyrroles with Aldimines"}]},{"@id":"https://cir.nii.ac.jp/crid/1050306506450527616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cp*Rh-III/Chiral Disulfonate/CuOAc Catalyst System for the Enantioselective Intramolecular Oxyamination of Alkenes"},{"@value":"Cp*Rh<sup>III</sup>/Chiral Disulfonate/CuOAc Catalyst System for the Enantioselective Intramolecular Oxyamination of Alkenes"}]},{"@id":"https://cir.nii.ac.jp/crid/1050869456405846656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pentamethylcyclopentadienyl rhodium(III)-chiral disulfonate hybrid catalysis for enantioselective C-H bond functionalization"}]},{"@id":"https://cir.nii.ac.jp/crid/1360008156677015168","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Chiral Calcium Bis-sulfonimide Catalyzed Diels-Alder Reactions of 1-Acryloyl-pyrazole"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285704748783872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"1,1′-Binaphthyl-2,2′-Disulfonic Acid"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285704870861824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Chiral 1,1′‐Binaphthyl‐2,2′‐Disulfonic Acid (BINSA) and Its Derivatives for Asymmetric Catalysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360286989542067712","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Diverse Approaches for Enantioselective C−H Functionalization Reactions Using Group 9 Cp<sup>x</sup>M<sup>III</sup> 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