The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
書誌事項
- 公開日
- 2010-04-20
- 権利情報
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- https://www.springernature.com/gp/researchers/text-and-data-mining
- https://www.springernature.com/gp/researchers/text-and-data-mining
- DOI
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- 10.1038/ni.1863
- 公開者
- Springer Science and Business Media LLC
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説明
The discovery of Toll-like receptors (TLRs) as components that recognize conserved structures in pathogens has greatly advanced understanding of how the body senses pathogen invasion, triggers innate immune responses and primes antigen-specific adaptive immunity. Although TLRs are critical for host defense, it has become apparent that loss of negative regulation of TLR signaling, as well as recognition of self molecules by TLRs, are strongly associated with the pathogenesis of inflammatory and autoimmune diseases. Furthermore, it is now clear that the interaction between TLRs and recently identified cytosolic innate immune sensors is crucial for mounting effective immune responses. Here we describe the recent advances that have been made by research into the role of TLR biology in host defense and disease.
収録刊行物
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- Nature Immunology
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Nature Immunology 11 (5), 373-384, 2010-04-20
Springer Science and Business Media LLC
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キーワード
詳細情報 詳細情報について
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- CRID
- 1363388844548628608
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- DOI
- 10.1038/ni.1863
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- ISSN
- 15292916
- 15292908
- http://id.crossref.org/issn/15292908
- https://id.crossref.org/issn/15292908
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- PubMed
- 20404851
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- データソース種別
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- Crossref
- OpenAIRE
