{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388844581908608.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1146/annurev.immunol.22.012703.104635"}},{"identifier":{"@type":"URI","@value":"https://www.annualreviews.org/doi/pdf/10.1146/annurev.immunol.22.012703.104635"}},{"identifier":{"@type":"NAID","@value":"30022122396"}}],"dc:title":[{"@value":"I\n                    <scp>mmunity to</scp>\n                    T\n                    <scp>uberculosis</scp>"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>▪ Abstract  Only 5 to 10% of immunocompetent humans are susceptible to tuberculosis, and over 85% of them develop the disease exclusively in the lungs. Human immunodeficiency virus (HIV)-infected humans, in contrast, can develop systemic disease that is more quickly lethal. This is in keeping with other evidence showing that susceptible humans generate some level of Th1 immunity to Mycobacterium tuberculosis (Mtb) infection. Tuberculosis in mice is also exclusively a lung disease that is progressive and lethal, in spite of the generation of Th1-mediated immunity. Thus mouse tuberculosis is a model of tuberculosis in susceptible humans, as is tuberculosis in guinea pigs and rabbits. Inability to resolve infection and prevent disease may not be a consequence of the generation of an inadequate number of Th1 cells but of an intrinsic deficiency in macrophage function that prevents these cells from expressing immunity. If this proves to be true, vaccinating susceptible humans against tuberculosis will be a difficult task.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388844581908736","@type":"Researcher","foaf:name":[{"@value":"Robert J. North"}],"jpcoar:affiliationName":[{"@value":"The Trudeau Institute, Saranac Lake, New York 12983;"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388844581908608","@type":"Researcher","foaf:name":[{"@value":"Yu-Jin Jung"}],"jpcoar:affiliationName":[{"@value":"The Trudeau Institute, Saranac Lake, New York 12983;"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"07320582"},{"@type":"EISSN","@value":"15453278"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/07320582"},{"@type":"NCID","@value":"AA10636710"}],"prism:publicationName":[{"@value":"Annual Review of Immunology"}],"dc:publisher":[{"@value":"Annual Reviews"}],"prism:publicationDate":"2004-04-01","prism:volume":"22","prism:number":"1","prism:startingPage":"599","prism:endingPage":"623"},"reviewed":"false","url":[{"@id":"https://www.annualreviews.org/doi/pdf/10.1146/annurev.immunol.22.012703.104635"}],"createdAt":"2004-03-19","modifiedAt":"2023-04-28","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360565167342294528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dectin-1 diversifies <i>Aspergillus fumigatus</i>–specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168120956800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Transcriptional and epigenetic networks of helper T and innate lymphoid cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182167453696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dispensable role of chemokine receptors in migration of mycobacterial antigen-specific CD4+ T cells into Mycobacterium-infected lung"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567184565179008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Suppressed induction of mycobacterial antigen-specific Th1-type CD4+ T cells in the lung after pulmonary mycobacterial infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643597239936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Characteristics of Suppressor Macrophages Induced by Mycobacterial and Protozoal Infections in relation to Alternatively Activated M2 Macrophages"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593694439424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evaluation of a booster tuberculosis vaccine containing mycobacterial DNA-binding protein 1 and CpG oligodeoxynucleotide G9.1 using a Guinea pig model that elicits immunity to Bacillus Calmette–Guérin"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206322938368","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Molecular Pathogenesis of Mycobacterial Diseases"},{"@value":"抗酸菌病原因子と宿主応答の分子機序"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1146/annurev.immunol.22.012703.104635"},{"@type":"CIA","@value":"30022122396"},{"@type":"CROSSREF","@value":"10.1084/jem.20100906_references_DOI_QCvlnDii1vlvNe9lWDg5hTB4bGN"},{"@type":"CROSSREF","@value":"10.1111/imr.12208_references_DOI_QCvlnDii1vlvNe9lWDg5hTB4bGN"},{"@type":"CROSSREF","@value":"10.1093/intimm/dxq010_references_DOI_QCvlnDii1vlvNe9lWDg5hTB4bGN"},{"@type":"CROSSREF","@value":"10.1155/2012/635451_references_DOI_QCvlnDii1vlvNe9lWDg5hTB4bGN"},{"@type":"CROSSREF","@value":"10.1016/j.tube.2021.102067_references_DOI_QCvlnDii1vlvNe9lWDg5hTB4bGN"},{"@type":"CROSSREF","@value":"10.1016/j.imbio.2019.01.006_references_DOI_QCvlnDii1vlvNe9lWDg5hTB4bGN"}]}