{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388844733728896.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/j.1365-2443.2010.01450.x"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2443.2010.01450.x"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2443.2010.01450.x"}},{"identifier":{"@type":"PMID","@value":"20964795"}}],"dc:title":[{"@value":"Necl‐5/PVR enhances PDGF‐induced attraction of growing microtubules to the plasma membrane of the leading edge of moving NIH3T3 cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Microtubules (MTs) search for and grow toward the leading edge of moving cells, followed by their stabilization at a specific structure at the rear site of the leading edge. This dynamic re‐orientation of MTs is critical to directional cell movement. We previously showed that Necl‐5/poliovirus receptor (PVR) interacts with platelet‐derived growth factor (PDGF) receptor and integrin α<jats:sub>v</jats:sub>β<jats:sub>3</jats:sub> at the leading edge of moving NIH3T3 cells, resulting in an enhancement of their directional movement. We studied here the role of Necl‐5 in the PDGF‐induced attraction of growing MTs to the leading edge of NIH3T3 cells. Necl‐5 enhanced the PDGF‐induced growth of MTs and attracted them near to the plasma membrane of the leading edge of NIH3T3 cells in an integrin α<jats:sub>v</jats:sub>β<jats:sub>3</jats:sub>‐dependent manner. Furthermore, Necl‐5 enhanced the PDGF‐induced attraction of the plus‐end‐tracking proteins (+TIPs), including EB1, CLIP170, an intermediate chain subunit of cytoplasmic dynein, and p150<jats:sup>Glued</jats:sup>, a subunit of dynactin, near to the plasma membrane of the leading edge. Thus, Necl‐5 plays a role in the attraction of growing MTs to the plasma membrane of the leading edge of moving cells.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388844733728901","@type":"Researcher","foaf:name":[{"@value":"Akihiro Minami"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801187454336","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50559177"},{"@type":"NRID","@value":"1000050559177"},{"@type":"NRID","@value":"9000409333133"},{"@type":"NRID","@value":"9000406035069"},{"@type":"NRID","@value":"9000292872404"},{"@type":"NRID","@value":"9000412200677"},{"@type":"NRID","@value":"9000412107553"},{"@type":"NRID","@value":"9000015315484"},{"@type":"NRID","@value":"9000378105153"},{"@type":"NRID","@value":"9000413496471"},{"@type":"NRID","@value":"9000412078137"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/mizu-kiyo"}],"foaf:name":[{"@value":"Kiyohito Mizutani"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388844733728898","@type":"Researcher","foaf:name":[{"@value":"Masazumi Waseda"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388844733728899","@type":"Researcher","foaf:name":[{"@value":"Mihoko Kajita"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388844733728900","@type":"Researcher","foaf:name":[{"@value":"Muneaki Miyata"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388844733728902","@type":"Researcher","foaf:name":[{"@value":"Wataru Ikeda"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388844733728897","@type":"Researcher","foaf:name":[{"@value":"Yoshimi Takai"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13569597"},{"@type":"EISSN","@value":"13652443"}],"prism:publicationName":[{"@value":"Genes to Cells"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2010-10-21","prism:volume":"15","prism:number":"11","prism:startingPage":"1123","prism:endingPage":"1135"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2443.2010.01450.x"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2443.2010.01450.x"}],"createdAt":"2010-10-21","modifiedAt":"2023-10-30","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Platelet-Derived%20Growth%20Factor","dc:title":"Platelet-Derived Growth Factor"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Membrane","dc:title":"Cell Membrane"},{"@id":"https://cir.nii.ac.jp/all?q=Integrin%20alphaVbeta3","dc:title":"Integrin alphaVbeta3"},{"@id":"https://cir.nii.ac.jp/all?q=Microtubules","dc:title":"Microtubules"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasm%20Proteins","dc:title":"Neoplasm Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Movement","dc:title":"Cell Movement"},{"@id":"https://cir.nii.ac.jp/all?q=NIH%203T3%20Cells","dc:title":"NIH 3T3 Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Virus","dc:title":"Receptors, Virus"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Binding","dc:title":"Protein Binding"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050575520345653760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Localization of nectin‐2α at the boundary between the adjacent somata of the clustered cholinergic neurons and its regulatory role in the 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