{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388844753354112.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/j.1552-4604.1998.tb04393.x"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fj.1552-4604.1998.tb04393.x"}},{"identifier":{"@type":"URI","@value":"https://accp1.onlinelibrary.wiley.com/doi/pdf/10.1002/j.1552-4604.1998.tb04393.x"}}],"dc:title":[{"@value":"Effect of Grapefruit Juice on the Pharmacokinetics of Microemulsion Cyclosporine and its Metabolite in Healthy Volunteers: Does the Formulation Difference Matter?"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>This study was conducted to determine the effect of grapefruit juice on the pharmacokinetics of microemulsion cyclosporine and its major metabolites, M1 and M17, in 12 healthy volunteers. Each subject received two oral doses of microemulsion cyclosporine with water or grapefruit juice. Each subject also received intravenous cyclosporine on a separate occasion. Blood samples were collected for assay of cyclosporine, M1, and M17 during a 24‐hour period, and were analyzed by a high‐performace liquid chromatography method. Compared with water, administration with grapefruit juice significantly increased peak concentration (C<jats:sub>max</jats:sub>) and area under the concentration‐time (AUC) of cyclosporine. Administration with grapefruit juice increased the absolute bioavailability of microemulsion cyclosporine by 45%. For cyclosporine metabolites, administration with grapefruit juice decreased the C<jats:sub>max</jats:sub>and AUC of M1 by 21% and 15%, respectively. These findings suggest that concurrent administration with grapefruit juice increases the bioavailability of microemulsion cyclosporine significantly compared with water in healthy volunteers. The grapefruit juice affects each metabolite formation and its pharmacokinetics differently, which suggests that the major site of its formation is different.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380579819126135552","@type":"Researcher","foaf:name":[{"@value":"Yi‐Min Ku"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388844753354114","@type":"Researcher","foaf:name":[{"@value":"David I. Min"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388844753354113","@type":"Researcher","foaf:name":[{"@value":"Michael Flanigan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00912700"},{"@type":"EISSN","@value":"15524604"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00912700"}],"prism:publicationName":[{"@value":"The Journal of Clinical Pharmacology"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"1998-10","prism:volume":"38","prism:number":"10","prism:startingPage":"959","prism:endingPage":"965"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fj.1552-4604.1998.tb04393.x"},{"@id":"https://accp1.onlinelibrary.wiley.com/doi/pdf/10.1002/j.1552-4604.1998.tb04393.x"}],"createdAt":"2013-03-08","modifiedAt":"2025-04-29","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285709891699456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cyclosporine A-Based Immunotherapy in Adult Living Donor Liver Transplantation: Accurate and Improved Therapeutic Drug Monitoring by 4-hr Intravenous Infusion"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204874521472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"薬物相互作用（１０―免疫抑制薬の薬物相互作用）"},{"@language":"en","@value":"Drug interaction (10. combination with immunosuppressive drugs)"},{"@value":"ニュース&ビュー 薬物相互作用(10)免疫抑制薬の薬物相互作用"},{"@language":"ja-Kana","@value":"ニュース ビュー ヤクブツ ソウゴ サヨウ 10 メンエキ ヨクセイヤク ノ ヤクブツ ソウゴ サヨウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680158277504","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Contribution of Intestinal Cytochrome P450-Mediated Metabolism to Drug-Drug Inhibition and Induction Interactions"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/j.1552-4604.1998.tb04393.x"},{"@type":"CROSSREF","@value":"10.2133/dmpk.25.28_references_DOI_DVI908slhRkGe5FYtRtnxTdyhZ8"},{"@type":"CROSSREF","@value":"10.4044/joma.119.199_references_DOI_DVI908slhRkGe5FYtRtnxTdyhZ8"},{"@type":"CROSSREF","@value":"10.1097/tp.0b013e31821dcae3_references_DOI_DVI908slhRkGe5FYtRtnxTdyhZ8"}]}