The role of structure, energy landscape, dynamics, and allostery in the enzymatic function of myoglobin
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- Hans Frauenfelder
- Center for Nonlinear Studies, MS-B 258, Los Alamos National Laboratory, Los Alamos, NM 87545; Departments of Physics and Chemistry, Princeton University, Princeton, NJ 08544; and Department of Physics, Cook Building, University of Vermont, Burlington, VT 05405
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- Benjamin H. McMahon
- Center for Nonlinear Studies, MS-B 258, Los Alamos National Laboratory, Los Alamos, NM 87545; Departments of Physics and Chemistry, Princeton University, Princeton, NJ 08544; and Department of Physics, Cook Building, University of Vermont, Burlington, VT 05405
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- Robert H. Austin
- Center for Nonlinear Studies, MS-B 258, Los Alamos National Laboratory, Los Alamos, NM 87545; Departments of Physics and Chemistry, Princeton University, Princeton, NJ 08544; and Department of Physics, Cook Building, University of Vermont, Burlington, VT 05405
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- Kelvin Chu
- Center for Nonlinear Studies, MS-B 258, Los Alamos National Laboratory, Los Alamos, NM 87545; Departments of Physics and Chemistry, Princeton University, Princeton, NJ 08544; and Department of Physics, Cook Building, University of Vermont, Burlington, VT 05405
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- John T. Groves
- Center for Nonlinear Studies, MS-B 258, Los Alamos National Laboratory, Los Alamos, NM 87545; Departments of Physics and Chemistry, Princeton University, Princeton, NJ 08544; and Department of Physics, Cook Building, University of Vermont, Burlington, VT 05405
書誌事項
- 公開日
- 2001-02-20
- DOI
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- 10.1073/pnas.041614298
- 公開者
- Proceedings of the National Academy of Sciences
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説明
<jats:p> The grail of protein science is the connection between structure and function. For myoglobin (Mb) this goal is close. Described as only a passive dioxygen storage protein in texts, we argue here that Mb is actually an allosteric enzyme that can catalyze reactions among small molecules. Studies of the structural, spectroscopic, and kinetic properties of Mb lead to a model that relates structure, energy landscape, dynamics, and function. Mb functions as a miniature chemical reactor, concentrating and orienting diatomic molecules such as NO, CO, O <jats:sub>2</jats:sub> , and H <jats:sub>2</jats:sub> O <jats:sub>2</jats:sub> in highly conserved internal cavities. Reactions can be controlled because Mb exists in distinct taxonomic substates with different catalytic properties and connectivities of internal cavities. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 98 (5), 2370-2374, 2001-02-20
Proceedings of the National Academy of Sciences
