{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388845182740992.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/mabi.201500115"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmabi.201500115"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/mabi.201500115"}}],"dc:title":[{"@value":"Neurogenesis Is Induced by Electrical Stimulation of Human Mesenchymal Stem Cells Co‐Cultured With Mature Neuronal Cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec><jats:label/><jats:p>For electrical stimulation of hMSCs, gold nanoparticles were coated onto polyethyleneimine coated glass cover slips. The effects of pulsed or constant electrical stimulation upon cytotoxicity and differentiation of hMSCs were examined. The effects of co culturing hMSCs with neuronal cells were also tested. The neuronal differentiation of the stem cells was evaluated by determining the expression of neuron‐specific genes and proteins using RT‐PCR and Western blotting. Morphological changes were evaluated by scanning electron microscopy. The hMSCs co‐cultured with mature neuronal cells and stimulated with electrical shock showed the greatest level of neurite outgrowth (>150 mm) and smaller cell body sizes.<jats:inline-graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"graphic/mabi201500115-gra-0001.png\" xlink:title=\"mabi201500115-gra-0001\"/></jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388845182740996","@type":"Researcher","foaf:name":[{"@value":"Sang Jun Park"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Tissue Engineering Korea Institute of Radiological and Medical Sciences 215‐4, Gongneung Nowon Seoul‐si 139‐240 Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845182740994","@type":"Researcher","foaf:name":[{"@value":"Ji Sun Park"}],"jpcoar:affiliationName":[{"@value":"Department of Biomedical Science, College of Life Science CHA University 6F, CHA Bio‐Complex 689 Sampyeong‐dong Bundang‐gu Seongnam‐si 463‐400 Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845182740992","@type":"Researcher","foaf:name":[{"@value":"Han Na Yang"}],"jpcoar:affiliationName":[{"@value":"Department of Biomedical Science, College of Life Science CHA University 6F, CHA Bio‐Complex 689 Sampyeong‐dong Bundang‐gu Seongnam‐si 463‐400 Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845182740997","@type":"Researcher","foaf:name":[{"@value":"Se Won Yi"}],"jpcoar:affiliationName":[{"@value":"Department of Biomedical Science, College of Life Science CHA University 6F, CHA Bio‐Complex 689 Sampyeong‐dong Bundang‐gu Seongnam‐si 463‐400 Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579816903539456","@type":"Researcher","foaf:name":[{"@value":"Chun‐Ho Kim"}],"jpcoar:affiliationName":[{"@value":"Laboratory of Tissue Engineering Korea Institute of Radiological and Medical Sciences 215‐4, Gongneung Nowon Seoul‐si 139‐240 Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579816903539457","@type":"Researcher","foaf:name":[{"@value":"Keun‐Hong Park"}],"jpcoar:affiliationName":[{"@value":"Department of Biomedical Science, College of Life Science CHA University 6F, CHA Bio‐Complex 689 Sampyeong‐dong Bundang‐gu Seongnam‐si 463‐400 Korea"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"16165187"},{"@type":"EISSN","@value":"16165195"}],"prism:publicationName":[{"@value":"Macromolecular Bioscience"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2015-07-17","prism:volume":"15","prism:number":"11","prism:startingPage":"1586","prism:endingPage":"1594"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor","http://doi.wiley.com/10.1002/tdm_license_1.1","http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmabi.201500115"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/mabi.201500115"}],"createdAt":"2015-07-17","modifiedAt":"2023-10-03","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360005519870679936","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Involvement of PDGF-BB and IGF-1 in Activation of Human Schwann Cells by Platelet-Rich Plasma"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/mabi.201500115"},{"@type":"CROSSREF","@value":"10.1097/prs.0000000000006266_references_DOI_XegRwftvqeDtKqM5hIdiMs8atVE"}]}