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Principles and typical examples of this method, in particular applications to biologically related reactions, are reviewed. The pulsed laser induced transient grating signal of the photo-decomposition reaction of caged ATP showed that the diffusion coefficient increases gradually with time reflecting the molecular size decrease by the dissociation. Hence, this rate should be a direct measurement of the photo-dissociation rate of ATP from the caged state. In an application to a protein folding reaction, the time-development of the diffusion coefficient was observed during the folding reaction. This time dependence was interpreted in terms of the intermolecular interaction change; i.e., conversion from the intermolecular hydrogen bonding to intramolecular one. It was found that the change of the hydrogen bonding network occurred by the two state manner in entire refolding process of cytochrome c. The unique feature of this time-dependent diffusion coefficient method is discussed."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388845222800896","@type":"Researcher","foaf:name":[{"@value":"Masahide Terazima"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"14639076"},{"@type":"EISSN","@value":"14639084"}],"prism:publicationName":[{"@value":"Phys. Chem. Chem. 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