{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388845330179968.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1210/jc.2004-2552"}},{"identifier":{"@type":"URI","@value":"http://press.endocrine.org/doi/full/10.1210/jc.2004-2552"}},{"identifier":{"@type":"PMID","@value":"15972580"}}],"dc:title":[{"@value":"A New Active Vitamin D, ED-71, Increases Bone Mass in Osteoporotic Patients under Vitamin D Supplementation: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial"}],"description":[{"notation":[{"@value":"ED-71 has been shown to increase lumbar bone mineral density (BMD) in osteoporotic subjects. However, vitamin D insufficiency might have influenced the effect of ED-71 on BMD.Our objective was to examine whether ED-71 can increase BMD in osteoporotic patients under vitamin D supplementation.We conducted a randomized, double-blind, placebo-controlled clinical trial of 219 osteoporotic patients (49-87 yr of age).Subjects were randomly assigned to receive placebo or 0.5, 0.75, or 1.0 microg/d ED-71 for 12 months. All the subjects received 200 or 400 IU/d vitamin D(3).We assessed changes in lumbar and hip BMD and bone turnover markers from baseline.Lumbar BMD increased with ED-71 treatment for 12 months (2.2, 2.6, and 3.1% from baseline and 2.9, 3.4, and 3.8% vs. placebo group in subjects receiving 0.5, 0.75, and 1.0 microg ED-71, respectively). Total hip BMD also increased with 0.75 and 1.0 microg ED-71 (-0.8, 0.6, and 0.9% from baseline and 0.1, 1.5, and 1.8% vs. placebo group in the 0.5, 0.75, and 1.0 microg ED-71 groups, respectively). Bone formation and resorption markers were suppressed by approximately 20% after 12 months of 0.75 and 1.0 microg ED-71 treatment. Transient hypercalcemia over 2.6 mmol/liter occurred in 7, 5, and 23% of subjects in the 0.5, 0.75, and 1.0 microg ED-71 groups, respectively, but none of them developed sustained hypercalcemia.These results demonstrate that ED-71 treatment at around 0.75 microg/d can effectively and safely increase lumbar and hip BMD in osteoporotic patients with vitamin D supplementation."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388845330179975","@type":"Researcher","foaf:name":[{"@value":"Toshio Matsumoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845330179973","@type":"Researcher","foaf:name":[{"@value":"Takami Miki"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845330179974","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Hagino"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845330179968","@type":"Researcher","foaf:name":[{"@value":"Toshitsugu Sugimoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845330179970","@type":"Researcher","foaf:name":[{"@value":"Sumiaki Okamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845330179976","@type":"Researcher","foaf:name":[{"@value":"Takako Hirota"}]},{"@id":"https://cir.nii.ac.jp/crid/1420564276161384448","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"30179832"},{"@type":"NRID","@value":"1000030179832"},{"@type":"NRID","@value":"9000016807295"},{"@type":"NRID","@value":"9000014310376"},{"@type":"NRID","@value":"9000002923715"},{"@type":"NRID","@value":"9000018811617"},{"@type":"NRID","@value":"9000005268846"},{"@type":"NRID","@value":"9000279904344"},{"@type":"NRID","@value":"9000254697325"},{"@type":"NRID","@value":"9000018391925"},{"@type":"NRID","@value":"9000004670614"},{"@type":"NRID","@value":"9000279904346"},{"@type":"NRID","@value":"9000389547957"},{"@type":"NRID","@value":"9000254234245"},{"@type":"NRID","@value":"9000015311078"},{"@type":"NRID","@value":"9000020065251"},{"@type":"NRID","@value":"9000255838516"},{"@type":"NRID","@value":"9000256468295"},{"@type":"NRID","@value":"9000256468324"},{"@type":"NRID","@value":"9000257890049"},{"@type":"NRID","@value":"9000301735333"},{"@type":"NRID","@value":"9000321409992"},{"@type":"NRID","@value":"9000347046854"},{"@type":"NRID","@value":"9000254701865"},{"@type":"NRID","@value":"9000005216452"},{"@type":"NRID","@value":"9000020040066"},{"@type":"NRID","@value":"9000279904198"},{"@type":"NRID","@value":"9000257891689"},{"@type":"NRID","@value":"9000256468193"},{"@type":"NRID","@value":"9000256466927"},{"@type":"NRID","@value":"9000019050363"},{"@type":"NRID","@value":"9000254688542"},{"@type":"NRID","@value":"9000020070168"},{"@type":"NRID","@value":"9000020358358"},{"@type":"NRID","@value":"9000253211381"},{"@type":"NRID","@value":"9000257890043"},{"@type":"NRID","@value":"9000005123035"},{"@type":"NRID","@value":"9000020320502"},{"@type":"NRID","@value":"9000283796926"},{"@type":"NRID","@value":"9000399502420"},{"@type":"NRID","@value":"9000257796312"},{"@type":"NRID","@value":"9000364403253"},{"@type":"NRID","@value":"9000254697322"},{"@type":"NRID","@value":"9000258577392"},{"@type":"NRID","@value":"9000257688526"},{"@type":"NRID","@value":"9000018343972"},{"@type":"NRID","@value":"9000356877043"},{"@type":"NRID","@value":"9000002864762"},{"@type":"NRID","@value":"9000257890760"},{"@type":"NRID","@value":"9000256467471"},{"@type":"NRID","@value":"9000255748212"},{"@type":"NRID","@value":"9000017360847"},{"@type":"NRID","@value":"9000341528435"},{"@type":"NRID","@value":"9000020397284"},{"@type":"NRID","@value":"9000391908194"},{"@type":"NRID","@value":"9000254513177"},{"@type":"NRID","@value":"9000253265488"},{"@type":"NRID","@value":"9000256178037"},{"@type":"NRID","@value":"9000364922038"},{"@type":"NRID","@value":"9000004683223"},{"@type":"NRID","@value":"9000321409985"},{"@type":"NRID","@value":"9000020324488"},{"@type":"NRID","@value":"9000255838597"},{"@type":"NRID","@value":"9000256178043"},{"@type":"NRID","@value":"9000329006686"},{"@type":"NRID","@value":"9000254687812"},{"@type":"NRID","@value":"9000020354995"},{"@type":"NRID","@value":"9000321409660"},{"@type":"NRID","@value":"9000020358189"},{"@type":"NRID","@value":"9000020423552"},{"@type":"NRID","@value":"9000253263044"},{"@type":"NRID","@value":"9000256467189"},{"@type":"NRID","@value":"9000018173394"},{"@type":"NRID","@value":"9000020402018"},{"@type":"NRID","@value":"9000240188372"},{"@type":"NRID","@value":"9000283798610"},{"@type":"NRID","@value":"9000345294122"},{"@type":"NRID","@value":"9000015262840"},{"@type":"NRID","@value":"9000020071780"},{"@type":"NRID","@value":"9000021223560"},{"@type":"NRID","@value":"9000020093007"},{"@type":"NRID","@value":"9000045429611"},{"@type":"NRID","@value":"9000249250115"},{"@type":"NRID","@value":"9000283711783"},{"@type":"NRID","@value":"9000253262433"},{"@type":"NRID","@value":"9000402071629"},{"@type":"NRID","@value":"9000006821562"},{"@type":"NRID","@value":"9000321409994"},{"@type":"NRID","@value":"9000020376281"},{"@type":"NRID","@value":"9000019081704"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0164117"}],"foaf:name":[{"@value":"Yusuke Tanigawara"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845330179971","@type":"Researcher","foaf:name":[{"@value":"Yasufumi Hayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845330179978","@type":"Researcher","foaf:name":[{"@value":"Masao Fukunaga"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845330179969","@type":"Researcher","foaf:name":[{"@value":"Masataka Shiraki"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845330179972","@type":"Researcher","foaf:name":[{"@value":"Toshitaka Nakamura"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0021972X"},{"@type":"EISSN","@value":"19457197"}],"prism:publicationName":[{"@value":"The Journal of Clinical Endocrinology & Metabolism"}],"dc:publisher":[{"@value":"The Endocrine Society"}],"prism:publicationDate":"2005-09","prism:volume":"90","prism:number":"9","prism:startingPage":"5031","prism:endingPage":"5036"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://press.endocrine.org/doi/full/10.1210/jc.2004-2552"}],"createdAt":"2005-09-07","modifiedAt":"2017-03-30","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Absorptiometry,%20Photon","dc:title":"Absorptiometry, Photon"},{"@id":"https://cir.nii.ac.jp/all?q=Calcitriol","dc:title":"Calcitriol"},{"@id":"https://cir.nii.ac.jp/all?q=Double-Blind%20Method","dc:title":"Double-Blind Method"},{"@id":"https://cir.nii.ac.jp/all?q=Bone%20Density","dc:title":"Bone Density"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Vitamin%20D","dc:title":"Vitamin D"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Aged,%2080%20and%20over","dc:title":"Aged, 80 and over"},{"@id":"https://cir.nii.ac.jp/all?q=Lumbar%20Vertebrae","dc:title":"Lumbar Vertebrae"},{"@id":"https://cir.nii.ac.jp/all?q=Dose-Response%20Relationship,%20Drug","dc:title":"Dose-Response Relationship, Drug"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Hormones","dc:title":"Hormones"},{"@id":"https://cir.nii.ac.jp/all?q=Hypercalcemia","dc:title":"Hypercalcemia"},{"@id":"https://cir.nii.ac.jp/all?q=Osteoporosis","dc:title":"Osteoporosis"},{"@id":"https://cir.nii.ac.jp/all?q=Patient%20Compliance","dc:title":"Patient Compliance"},{"@id":"https://cir.nii.ac.jp/all?q=Calcium","dc:title":"Calcium"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Hip%20Joint","dc:title":"Hip Joint"},{"@id":"https://cir.nii.ac.jp/all?q=Bone%20Remodeling","dc:title":"Bone Remodeling"},{"@id":"https://cir.nii.ac.jp/all?q=Biomarkers","dc:title":"Biomarkers"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050025031476334848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Eldecalcitol, a second-generation vitamin D analog, drives bone minimodeling and reduces osteoclastic number in trabecular bone of ovariectomized rats"},{"@value":"Eldecalcitol, a second-generation vitamin D analog, drives bone minimodeling and reduces osteoclastic number in the trabecular bone of ovariectomized rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1050850247204971008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effect of eldecalcitol, an active vitamin D analog, on hip structure and biomechanical properties: 3D assessment by clinical CT."}]},{"@id":"https://cir.nii.ac.jp/crid/1360004230273599488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Human hepatic metabolism of the anti‐osteoporosis drug eldecalcitol involves sterol C4‐methyl oxidase"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004233397701888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Vitamin D endocrine system and osteoclasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236335548800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nuclear Receptors in Bone Physiology and Diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004237877108224","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Eldecalcitol: newly developed active vitamin D<sub>3</sub>analog for the treatment of osteoporosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142899488768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Vitamin D in The Regulation of Osteoclasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021393541538816","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Active vitamin D treatment in the prevention of sarcopenia in adults with prediabetes (DPVD ancillary study): a randomised controlled trial"}]},{"@id":"https://cir.nii.ac.jp/crid/1360022307168958208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Eldecalcitol is more effective for promoting osteogenesis than alfacalcidol in\n                  <i>Cyp27b1</i>\n                  -knockout Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690754675072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Bone effects of vitamin D – Discrepancies between in vivo and in vitro studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690811410560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures — A randomized, active comparator, double-blind study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693971390592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effects of eldecalcitol on cortical bone response to mechanical loading in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285706909490560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Metabolism and Action of 25-Hydroxy-19-nor-Vitamin D3 in Human Prostate Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565167085792896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Sphingosine-1-phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182277069184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synthesis of 14-epi-2α-hydroxypropoxy-1α,25-dihydroxy-19-nortachysterol and its hVDR binding"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182277149056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Novel screening system for high-affinity ligand of heredity vitamin D-resistant rickets-associated vitamin D receptor mutant R274L using bioluminescent sensor"}]},{"@id":"https://cir.nii.ac.jp/crid/1360580232157095168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effect of active vitamin D treatment on development of type 2 diabetes: DPVD randomised controlled trial in Japanese population"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584341829118848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Eldecalcitol Induces Minimodeling-Based Bone Formation and Inhibits Sclerostin Synthesis Preferentially in the Epiphyses Rather than the Metaphyses of the Long Bones in Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1360588381053829376","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Eldecalcitol Add-on to Risedronate Reduces Bone Loss From Aromatase Inhibitors in Postmenopausal Breast Cancer Patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640201490560","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Efficacy of combined treatment with alendronate (ALN) and eldecalcitol, a new active vitamin D analog, compared to that of concomitant ALN, vitamin D plus calcium treatment in Japanese patients with primary osteoporosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657253779328","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Mechanism of inhibitory action of Eldecalcitol, an active vitamin D analog, on bone resorption in vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658050135424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Development of Novel Bioluminescent Sensor to Detect and Discriminate between Vitamin D Receptor Agonists and Antagonists in Living Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567830961024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Vitamin D Receptor in Osteoblast-Lineage Cells Is Essential for the Proresorptive Activity of 1α,25(OH)2D3 In Vivo"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593816770432","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Morphological Assessment of the Biological Effects of Eldecalcitol"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861294960316416","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Robust osteogenic efficacy of 2α-heteroarylalkyl vitamin D analogue AH-1 in VDR (R270L) hereditary vitamin D-dependent rickets model rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694366577424896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Executive summary of the Japan Osteoporosis Society Guide for the Use of Bone Turnover Markers in the Diagnosis and Treatment of Osteoporosis (2018 Edition)"}]},{"@id":"https://cir.nii.ac.jp/crid/1363946394180586112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Eldecalcitol effects on osteoblastic differentiation and function in the presence or absence of osteoclastic bone 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