{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388845375338880.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/s10620-006-9138-9"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s10620-006-9138-9.pdf"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/article/10.1007/s10620-006-9138-9/fulltext.html"}},{"identifier":{"@type":"URI","@value":"http://link.springer.com/content/pdf/10.1007/s10620-006-9138-9"}},{"identifier":{"@type":"PMID","@value":"17429738"}}],"dc:title":[{"@value":"Curcumin Prevents the Development of Dextran Sulfate Sodium (DSS)-Induced Experimental Colitis"}],"description":[{"notation":[{"@value":"Curcumin is a phenolic natural product isolated from the rhizome of Curcuma longa (turmeric). We evaluated the effects of curcumin on the development of dextran sulfate sodium (DSS)-induced experimental colitis. BALB/c mice were fed a chow containing either 3.5% (wt/wt) DSS or 3.5% DSS + 2.0% (wt/wt) curcumin. The body weight loss was more apparent in DSS-treated mice than in DSS + curcumin-treated mice. The disease activity index, histological colitis score, and MPO activity were all significantly higher in DSS-treated mice than in DSS plus curcumin-treated mice. Microscopically, mucosal edema, cellular infiltration, and epithelial disruption were much more severe in DSS-treated mice than in DSS + curcumin-treated mice. In DSS + curcumin-treated mice, NF-kappaB activation was blocked in the mucosa. In conclusion, the development of DSS-induced colitis was significantly attenuated by curcumin. Being a nontoxic natural dietary product, curcumin could be useful in treatment of IBD patients."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388845375338882","@type":"Researcher","foaf:name":[{"@value":"Yasuyuki Deguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845375338885","@type":"Researcher","foaf:name":[{"@value":"Akira Andoh"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845375338884","@type":"Researcher","foaf:name":[{"@value":"Osamu Inatomi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845375338886","@type":"Researcher","foaf:name":[{"@value":"Yuhki Yagi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845375338880","@type":"Researcher","foaf:name":[{"@value":"Shigeki Bamba"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845375338883","@type":"Researcher","foaf:name":[{"@value":"Yoshio Araki"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845375338887","@type":"Researcher","foaf:name":[{"@value":"Kazunori Hata"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845375338881","@type":"Researcher","foaf:name":[{"@value":"Tomoyuki Tsujikawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845375338888","@type":"Researcher","foaf:name":[{"@value":"Yoshihide Fujiyama"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01632116"},{"@type":"EISSN","@value":"15732568"}],"prism:publicationName":[{"@value":"Digestive Diseases and Sciences"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2007-04-11","prism:volume":"52","prism:number":"11","prism:startingPage":"2993","prism:endingPage":"2998"},"reviewed":"false","dc:rights":["http://www.springer.com/tdm"],"url":[{"@id":"http://link.springer.com/content/pdf/10.1007/s10620-006-9138-9.pdf"},{"@id":"http://link.springer.com/article/10.1007/s10620-006-9138-9/fulltext.html"},{"@id":"http://link.springer.com/content/pdf/10.1007/s10620-006-9138-9"}],"createdAt":"2007-04-18","modifiedAt":"2024-02-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20BALB%20C","dc:title":"Mice, Inbred BALB C"},{"@id":"https://cir.nii.ac.jp/all?q=Curcumin","dc:title":"Curcumin"},{"@id":"https://cir.nii.ac.jp/all?q=Colon","dc:title":"Colon"},{"@id":"https://cir.nii.ac.jp/all?q=Dextran%20Sulfate","dc:title":"Dextran Sulfate"},{"@id":"https://cir.nii.ac.jp/all?q=Plasma%20Substitutes","dc:title":"Plasma Substitutes"},{"@id":"https://cir.nii.ac.jp/all?q=Antineoplastic%20Agents","dc:title":"Antineoplastic Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Colitis","dc:title":"Colitis"},{"@id":"https://cir.nii.ac.jp/all?q=Immunohistochemistry","dc:title":"Immunohistochemistry"},{"@id":"https://cir.nii.ac.jp/all?q=Disease%20Models,%20Animal","dc:title":"Disease Models, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Peroxidase","dc:title":"Peroxidase"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004232275742464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dietary polyphenols modulate intestinal barrier defects and inflammation in a murine model of colitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004239751716096","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Supplemental Naringenin Prevents Intestinal Barrier Defects and Inflammation in Colitic Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186825270272","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Production of lipid mediators across different disease stages of dextran sodium sulfate-induced colitis in mice"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1007/s10620-006-9138-9"},{"@type":"OPENAIRE","@value":"doi_dedup___::f754283d88300a43ecd7283b57e9d84e"},{"@type":"CROSSREF","@value":"10.3945/jn.113.174508_references_DOI_Q2oDgOp1VBJDOhhjOMvIWYlt775"},{"@type":"CROSSREF","@value":"10.1016/j.jff.2013.02.008_references_DOI_Q2oDgOp1VBJDOhhjOMvIWYlt775"},{"@type":"CROSSREF","@value":"10.1194/jlr.m079095_references_DOI_Q2oDgOp1VBJDOhhjOMvIWYlt775"}]}