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stereogenic center and a formal total synthesis of (−)-physostigmine"}],"description":[{"notation":[{"@value":"Abstract   This paper describes the preparation of a new chiral building block containing a benzylic quaternary stereogenic center via the highly enantioselective PLE-mediated hydrolysis of dimethyl 2-(2-chloro-5-methoxyphenyl)-2-methylmalonate, as well as the absolute configuration of the new chiral building block, which has been elucidated through the formal total synthesis of (−)-physostigmine."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388845419243267","@type":"Researcher","foaf:name":[{"@value":"Kaori Asakawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845419243264","@type":"Researcher","foaf:name":[{"@value":"Naoyoshi Noguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845419243265","@type":"Researcher","foaf:name":[{"@value":"Shingo Takashima"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845419243266","@type":"Researcher","foaf:name":[{"@value":"Masahisa 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