{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388845666548352.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1105/tpc.113.111013"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/plcell/article-pdf/25/6/2022/36949033/plcell_v25_6_2022.pdf"}}],"dc:title":[{"@value":"Evolution of a Complex Locus for Terpene Biosynthesis in\n                    <i>Solanum</i>"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>Functional gene clusters, containing two or more genes encoding different enzymes for the same pathway, are sometimes observed in plant genomes, most often when the genes specify the synthesis of specialized defensive metabolites. Here, we show that a cluster of genes in tomato (Solanum lycopersicum; Solanaceae) contains genes for terpene synthases (TPSs) that specify the synthesis of monoterpenes and diterpenes from cis-prenyl diphosphates, substrates that are synthesized by enzymes encoded by cis-prenyl transferase (CPT) genes also located within the same cluster. The monoterpene synthase genes in the cluster likely evolved from a diterpene synthase gene in the cluster by duplication and divergence. In the orthologous cluster in Solanum habrochaites, a new sesquiterpene synthase gene was created by a duplication event of a monoterpene synthase followed by a localized gene conversion event directed by a diterpene synthase gene. The TPS genes in the Solanum cluster encoding cis-prenyl diphosphate–utilizing enzymes are closely related to a tobacco (Nicotiana tabacum; Solanaceae) diterpene synthase encoding Z-abienol synthase (Nt-ABS). Nt-ABS uses the substrate copal-8-ol diphosphate, which is made from the all-trans geranylgeranyl diphosphate by copal-8-ol diphosphate synthase (Nt-CPS2). The Solanum gene cluster also contains an ortholog of Nt-CPS2, but it appears to encode a nonfunctional protein. Thus, the Solanum functional gene cluster evolved by duplication and divergence of TPS genes, together with alterations in substrate specificity to utilize cis-prenyl diphosphates and through the acquisition of CPT genes.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388845666548352","@type":"Researcher","foaf:name":[{"@value":"Yuki Matsuba"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845666548353","@type":"Researcher","foaf:name":[{"@value":"Thuong T.H. Nguyen"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845666548230","@type":"Researcher","foaf:name":[{"@value":"Krystle Wiegert"}],"jpcoar:affiliationName":[{"@value":"Department of Horticulture, Michigan State University, East Lansing, Michigan 48824"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845666548354","@type":"Researcher","foaf:name":[{"@value":"Vasiliki Falara"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845666548231","@type":"Researcher","foaf:name":[{"@value":"Eliana Gonzales-Vigil"}],"jpcoar:affiliationName":[{"@value":"Department of Horticulture, Michigan State University, East Lansing, Michigan 48824"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845666548356","@type":"Researcher","foaf:name":[{"@value":"Bryan Leong"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845666548225","@type":"Researcher","foaf:name":[{"@value":"Petra Schäfer"}],"jpcoar:affiliationName":[{"@value":"Leibniz-Institute of Plant Biochemistry, Department of Cell and Metabolic Biology, 06120 Halle (Saale), Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845666548229","@type":"Researcher","foaf:name":[{"@value":"David Kudrna"}],"jpcoar:affiliationName":[{"@value":"Arizona Genomics Institute, School of Plant Sciences, BIO5 Institute, University of Arizona, Tucson, Arizona 85721"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845666548357","@type":"Researcher","foaf:name":[{"@value":"Rod A. Wing"}],"jpcoar:affiliationName":[{"@value":"Arizona Genomics Institute, School of Plant Sciences, BIO5 Institute, University of Arizona, Tucson, Arizona 85721"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845666548228","@type":"Researcher","foaf:name":[{"@value":"Anthony M. Bolger"}],"jpcoar:affiliationName":[{"@value":"Max-Planck-Institute of Molecular Plant Physiology, 14476 Potsdam-Golm, Germany"},{"@value":"Institut für Biologie 1, Botanik, Rheinisch-Westfälische Technische Hochschule Aachen University, 52062 Aachen, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845666548224","@type":"Researcher","foaf:name":[{"@value":"Björn Usadel"}],"jpcoar:affiliationName":[{"@value":"Max-Planck-Institute of Molecular Plant Physiology, 14476 Potsdam-Golm, Germany"},{"@value":"Institut für Biologie 1, Botanik, Rheinisch-Westfälische Technische Hochschule Aachen University, 52062 Aachen, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845666548227","@type":"Researcher","foaf:name":[{"@value":"Alain Tissier"}],"jpcoar:affiliationName":[{"@value":"Leibniz-Institute of Plant Biochemistry, Department of Cell and Metabolic Biology, 06120 Halle (Saale), Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845666548355","@type":"Researcher","foaf:name":[{"@value":"Alisdair R. Fernie"}],"jpcoar:affiliationName":[{"@value":"Max-Planck-Institute of Molecular Plant Physiology, 14476 Potsdam-Golm, Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845666548226","@type":"Researcher","foaf:name":[{"@value":"Cornelius S. Barry"}],"jpcoar:affiliationName":[{"@value":"Department of Horticulture, Michigan State University, East Lansing, Michigan 48824"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845666548232","@type":"Researcher","foaf:name":[{"@value":"Eran Pichersky"}],"jpcoar:affiliationName":[{"@value":"Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"1532298X"},{"@type":"PISSN","@value":"10404651"}],"prism:publicationName":[{"@value":"The Plant Cell"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2013-06-01","prism:volume":"25","prism:number":"6","prism:startingPage":"2022","prism:endingPage":"2036"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://academic.oup.com/plcell/article-pdf/25/6/2022/36949033/plcell_v25_6_2022.pdf"}],"createdAt":"2013-06-11","modifiedAt":"2021-04-07","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004239504920832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Recent Advances in the Application of Metabolomics to Studies of Biogenic Volatile Organic Compounds (BVOC) Produced  by Plant"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617684873728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Co-regulation of Clustered and Neo-functionalized Genes in Plant-Specialized Metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118716412928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Integrated view of plant metabolic defense with particular focus on chewing herbivores"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846643292136576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Integrated omics analysis of specialized metabolism in medicinal plants"}]},{"@id":"https://cir.nii.ac.jp/crid/1360857593798840960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Structure‐based engineering of a short‐chain <i>cis</i>‐prenyltransferase to biosynthesize nonnatural all‐<i>cis</i>‐polyisoprenoids: molecular mechanisms for primer substrate recognition and ultimate product chain‐length determination"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707142076800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Lateral transfers lead to the birth of momilactone biosynthetic gene clusters in grass"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204326606208","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Recent progress in secondary metabolism of plant glandular trichomes"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1105/tpc.113.111013"},{"@type":"CROSSREF","@value":"10.3390/metabo4030699_references_DOI_So1thdOCmeakDDfB5XfUh2Qydg6"},{"@type":"CROSSREF","@value":"10.3390/plants9050622_references_DOI_So1thdOCmeakDDfB5XfUh2Qydg6"},{"@type":"CROSSREF","@value":"10.5511/plantbiotechnology.14.0701a_references_DOI_So1thdOCmeakDDfB5XfUh2Qydg6"},{"@type":"CROSSREF","@value":"10.1111/tpj.13485_references_DOI_So1thdOCmeakDDfB5XfUh2Qydg6"},{"@type":"CROSSREF","@value":"10.1111/febs.16392_references_DOI_So1thdOCmeakDDfB5XfUh2Qydg6"},{"@type":"CROSSREF","@value":"10.1111/jipb.13204_references_DOI_So1thdOCmeakDDfB5XfUh2Qydg6"},{"@type":"CROSSREF","@value":"10.1111/tpj.15893_references_DOI_So1thdOCmeakDDfB5XfUh2Qydg6"}]}