{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388845720883200.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1155/2007/74364"}},{"identifier":{"@type":"URI","@value":"http://downloads.hindawi.com/journals/ppar/2007/074364.pdf"}}],"dc:title":[{"@value":"PPARs in the Control of Uncoupling Proteins Gene Expression"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Uncoupling proteins (UCPs) are mitochondrial membrane transporters involved in the control of energy conversion in mitochondria. Experimental and genetic evidence relate dysfunctions of UCPs with metabolic syndrome and obesity. The PPAR subtypes mediate to a large extent the transcriptional regulation of the UCP genes, with a distinct relevance depending on the UCP gene and the tissue in which it is expressed. UCP1 gene is under the dual control of PPAR<mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" id=\"E1\"><mml:mi>γ</mml:mi></mml:math>and PPAR<mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" id=\"E2\"><mml:mi>α</mml:mi></mml:math>in relation to brown adipocyte differentiation and lipid oxidation, respectively. UCP3 gene is regulated by PPAR<mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" id=\"E3\"><mml:mi>α</mml:mi></mml:math>and PPAR<mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" id=\"E4\"><mml:mi>δ</mml:mi></mml:math>in the muscle, heart, and adipose tissues. UCP2 gene is also under the control of PPARs even in tissues in which it is the predominantly expressed UCP (eg, the pancreas and liver). This review summarizes the current understanding of the role of PPARs in UCPs gene expression in normal conditions and also in the context of type-2 diabetes or obesity.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388845720883202","@type":"Researcher","foaf:name":[{"@value":"Francesc Villarroya"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845720883201","@type":"Researcher","foaf:name":[{"@value":"Roser Iglesias"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845720883200","@type":"Researcher","foaf:name":[{"@value":"Marta Giralt"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"16874757"},{"@type":"EISSN","@value":"16874765"}],"prism:publicationName":[{"@value":"PPAR Research"}],"dc:publisher":[{"@value":"Hindawi Limited"}],"prism:publicationDate":"2007","prism:volume":"2007","prism:startingPage":"1","prism:endingPage":"12"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by/3.0/"],"url":[{"@id":"http://downloads.hindawi.com/journals/ppar/2007/074364.pdf"}],"createdAt":"2007-03-05","modifiedAt":"2024-02-11","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050564288162604672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endoplasmic Reticulum Stress Impaired Uncoupling Protein 1 Expression via the Suppression of Peroxisome Proliferator-Activated Receptor γ Binding Activity in Mice Beige Adipocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004236798033024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The genetic association study between polymorphisms in uncoupling protein 2 and uncoupling 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