{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388845746670592.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1242/dev.005611"}},{"identifier":{"@type":"URI","@value":"http://journals.biologists.com/dev/article-pdf/134/14/2627/1523832/2627.pdf"}},{"identifier":{"@type":"PMID","@value":"17567665"}}],"dc:title":[{"@value":"Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>We previously reported that primordial germ cells (PGCs) in mice erase genome-wide DNA methylation and histone H3 lysine9 dimethylation (H3K9me2),and instead acquire high levels of tri-methylation of H3K27 (H3K27me3) during their migration, a process that might be crucial for the re-establishment of potential totipotency in the germline. We here explored a cellular dynamics associated with this epigenetic reprogramming. We found that PGCs undergo erasure of H3K9me2 and upregulation of H3K27me3 in a progressive, cell-by-cell manner, presumably depending on their developmental maturation. Before or concomitant with the onset of H3K9 demethylation, PGCs entered the G2 arrest of the cell cycle, which apparently persisted until they acquired high H3K27me3 levels. Interestingly, PGCs exhibited repression of RNA polymerase II-dependent transcription, which began after the onset of H3K9me2 reduction in the G2 phase and tapered off after the acquisition of high-level H3K27me3. The epigenetic reprogramming and transcriptional quiescence were independent from the function of Nanos3. We found that before H3K9 demethylation, PGCs exclusively repress an essential histone methyltransferase, GLP, without specifically upregulating histone demethylases. We suggest the possibility that active repression of an essential enzyme and subsequent unique cellular dynamics ensures successful implementation of genome-wide epigenetic reprogramming in migrating PGCs.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388845746670601","@type":"Researcher","foaf:name":[{"@value":"Yoshiyuki Seki"}],"jpcoar:affiliationName":[{"@value":"Laboratory for Mammalian Germ Cell Biology, Center for Developmental Biology,RIKEN Kobe Institute, 2-2-3 Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047,Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845746670596","@type":"Researcher","foaf:name":[{"@value":"Masashi Yamaji"}],"jpcoar:affiliationName":[{"@value":"Laboratory for Mammalian Germ Cell Biology, Center for Developmental Biology,RIKEN Kobe Institute, 2-2-3 Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047,Japan."},{"@value":"Laboratory of Molecular Cell Biology and Development, Graduate School of Biostudies, Kyoto University, Oiwake-cho, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845746670592","@type":"Researcher","foaf:name":[{"@value":"Yukihiro Yabuta"}],"jpcoar:affiliationName":[{"@value":"Laboratory for Mammalian Germ Cell Biology, Center for Developmental Biology,RIKEN Kobe Institute, 2-2-3 Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047,Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845746670593","@type":"Researcher","foaf:name":[{"@value":"Mitsue Sano"}],"jpcoar:affiliationName":[{"@value":"Laboratory for Mammalian Germ Cell Biology, Center for Developmental Biology,RIKEN Kobe Institute, 2-2-3 Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047,Japan."},{"@value":"Department of Biosystems Science, Graduate School of Science and Technology,Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845746670595","@type":"Researcher","foaf:name":[{"@value":"Mayo Shigeta"}],"jpcoar:affiliationName":[{"@value":"Laboratory for Mammalian Germ Cell Biology, Center for Developmental Biology,RIKEN Kobe Institute, 2-2-3 Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047,Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845746670594","@type":"Researcher","foaf:name":[{"@value":"Yasuhisa Matsui"}],"jpcoar:affiliationName":[{"@value":"Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo-cho, Aoba-ku, Sendai 980-8575,Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845746670598","@type":"Researcher","foaf:name":[{"@value":"Yumiko Saga"}],"jpcoar:affiliationName":[{"@value":"Department of Genetics and Division of Mammalian Development, National Institute of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411-8540,Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845746670597","@type":"Researcher","foaf:name":[{"@value":"Makoto Tachibana"}],"jpcoar:affiliationName":[{"@value":"Department of Cell Biology, Institute for Virus Research, Kyoto University,Shogoin Kawara-cho, Kyoto 606-8507, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845746670599","@type":"Researcher","foaf:name":[{"@value":"Yoichi Shinkai"}],"jpcoar:affiliationName":[{"@value":"Department of Cell Biology, Institute for Virus Research, Kyoto University,Shogoin Kawara-cho, Kyoto 606-8507, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845746670600","@type":"Researcher","foaf:name":[{"@value":"Mitinori Saitou"}],"jpcoar:affiliationName":[{"@value":"Laboratory for Mammalian Germ Cell Biology, Center for Developmental Biology,RIKEN Kobe Institute, 2-2-3 Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047,Japan."},{"@value":"Laboratory of Molecular Cell Biology and Development, Graduate School of Biostudies, Kyoto University, Oiwake-cho, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan."},{"@value":"Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, 4-1-8 Hon-cho, Kawaguchi, Saitama 332-0012, Japan."}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14779129"},{"@type":"PISSN","@value":"09501991"}],"prism:publicationName":[{"@value":"Development"}],"dc:publisher":[{"@value":"The Company of Biologists"}],"prism:publicationDate":"2007-07-15","prism:volume":"134","prism:number":"14","prism:startingPage":"2627","prism:endingPage":"2638"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://journals.biologists.com/dev/article-pdf/134/14/2627/1523832/2627.pdf"}],"createdAt":"2007-06-14","modifiedAt":"2024-02-15","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=G2%20Phase","dc:title":"G2 Phase"},{"@id":"https://cir.nii.ac.jp/all?q=Transcriptional%20Activation","dc:title":"Transcriptional Activation"},{"@id":"https://cir.nii.ac.jp/all?q=Chromosomal%20Proteins,%20Non-Histone","dc:title":"Chromosomal Proteins, Non-Histone"},{"@id":"https://cir.nii.ac.jp/all?q=Methylation","dc:title":"Methylation"},{"@id":"https://cir.nii.ac.jp/all?q=Epigenesis,%20Genetic","dc:title":"Epigenesis, Genetic"},{"@id":"https://cir.nii.ac.jp/all?q=Histones","dc:title":"Histones"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Movement","dc:title":"Cell Movement"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Lineage","dc:title":"Cell Lineage"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Methyltransferases","dc:title":"Protein Methyltransferases"},{"@id":"https://cir.nii.ac.jp/all?q=Stem%20Cells","dc:title":"Stem Cells"},{"@id":"https://cir.nii.ac.jp/all?q=RNA-Binding%20Proteins","dc:title":"RNA-Binding Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Oxidoreductases,%20N-Demethylating","dc:title":"Oxidoreductases, N-Demethylating"},{"@id":"https://cir.nii.ac.jp/all?q=Histone-Lysine%20N-Methyltransferase","dc:title":"Histone-Lysine N-Methyltransferase"},{"@id":"https://cir.nii.ac.jp/all?q=Chromatin%20Assembly%20and%20Disassembly","dc:title":"Chromatin Assembly and Disassembly"},{"@id":"https://cir.nii.ac.jp/all?q=Embryo,%20Mammalian","dc:title":"Embryo, Mammalian"},{"@id":"https://cir.nii.ac.jp/all?q=Repressor%20Proteins","dc:title":"Repressor Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Germ%20Cells","dc:title":"Germ Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Histone%20Methyltransferases","dc:title":"Histone Methyltransferases"},{"@id":"https://cir.nii.ac.jp/all?q=Positive%20Regulatory%20Domain%20I-Binding%20Factor%201","dc:title":"Positive Regulatory Domain I-Binding Factor 1"},{"@id":"https://cir.nii.ac.jp/all?q=RNA%20Polymerase%20II","dc:title":"RNA Polymerase II"},{"@id":"https://cir.nii.ac.jp/all?q=Transcription%20Factors","dc:title":"Transcription Factors"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050293015560399616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mammalian Germ Cell Development: From Mechanism to InVitro Reconstitution"}]},{"@id":"https://cir.nii.ac.jp/crid/1050296188316540800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Ex vivo reconstitution of fetal oocyte development in humans and cynomolgus monkeys"},{"@value":"<i>Ex vivo</i>\n                    reconstitution of fetal oocyte development in humans and cynomolgus monkeys"}]},{"@id":"https://cir.nii.ac.jp/crid/1050848249735156608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"ZGLP1 is a determinant for the oogenic fate in 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Mice1"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142767840896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cyclosporin A and FGF signaling support the proliferation/survival of mouse primordial germ cell-like cells in vitro†"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142801894784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The PRDM14–CtBP1/2–PRC2 complex regulates transcriptional repression during the transition from primed to naïve pluripotency"}]},{"@id":"https://cir.nii.ac.jp/crid/1360021390767993984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Epigenetic Mechanisms Governing Female and Male Germline Development in Mammals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283690829006976","@type":"Article","resourceType":"学術雑誌論文(journal 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cells using piggyBac and Tol2 transposons"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692582030720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283694068241920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285705284654080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Induction of Primordial Germ Cell-Like Cells From Mouse Embryonic Stem Cells by ERK Signal Inhibition"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707533837952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"REST and its downstream molecule Mek5 regulate survival of primordial germ cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708376944256","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genomic imprinting in mammals: its life cycle, molecular mechanisms and reprogramming"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285709924606592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>Setdb1</i>\n                    is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710586681600","@type":"Article","resourceType":"学術雑誌論文(journal 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primordial germ cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169334340608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"New Evidence Confirms That the Mitochondrial Bottleneck Is Generated without Reduction of Mitochondrial DNA Content in Early Primordial Germ Cells of Mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181259496832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cell cycle reentry from the late S phase: implications from stem cell formation in the moss Physcomitrella patens"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567181270553088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Differentiation of Mouse Primordial Germ Cells into Functional Oocytes In Vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182467327616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182510310528","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evidence for crucial role of hindgut expansion in directing proper migration of primordial germ cells in mouse early embryogenesis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183382423680","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Max is a repressor of germ cell-related gene expression in mouse embryonic stem 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