{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388845803544832.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2217/14622416.9.11.1617"}},{"identifier":{"@type":"URI","@value":"https://www.tandfonline.com/doi/pdf/10.2217/14622416.9.11.1617"}},{"identifier":{"@type":"PMID","@value":"19018717"}}],"dc:title":[{"@value":"HLA-B Locus in Japanese Patients with Anti-Epileptics and Allopurinol-Related Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis"}],"description":[{"notation":[{"@value":"Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of HLA-B*1502 and HLA-B*5801 with carbamazepine- and allopurinol-induced severe cutaneous adverse reactions were found in Han Chinese patients, respectively, but ethnic differences in the associations have been reported. The objective of this study is to clarify the involvement of HLA-B*1502 and HLA-B*5801 in Japanese SJS/TEN patients.HLA-B genotyping was performed on 58 Japanese SJS/TEN patients between July 2006 and April 2008 from multicenters in Japan.There were no HLA-B*1502 carriers among 58 SJS/TEN patients. This patient group included seven carbamazepine-related and 11 aromatic anti-epileptic agent-related SJS/TEN patients. In addition, there were five HLA-B*5801 carriers, which included four allopurinol-related SJS/TEN patients.While HLA-B*1502 is unlikely to be associated with carbamazepine-related or aromatic anti-epileptic agent-related SJS/TEN, HLA-B*5801 was significantly associated with allopurinol-related SJS/TEN in Japanese."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388845803544840","@type":"Researcher","foaf:name":[{"@value":"Nahoko Kaniwa"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845803544846","@type":"Researcher","foaf:name":[{"@value":"Yoshiro Saito"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845803544850","@type":"Researcher","foaf:name":[{"@value":"Michiko Aihara"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845803544837","@type":"Researcher","foaf:name":[{"@value":"Kayoko Matsunaga"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845803544848","@type":"Researcher","foaf:name":[{"@value":"Masahiro Tohkin"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845803544842","@type":"Researcher","foaf:name":[{"@value":"Kouichi Kurose"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845803544833","@type":"Researcher","foaf:name":[{"@value":"Jun-ichi Sawada"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845803544844","@type":"Researcher","foaf:name":[{"@value":"Hirokazu Furuya"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845803544843","@type":"Researcher","foaf:name":[{"@value":"Yukitoshi Takahashi"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845803544838","@type":"Researcher","foaf:name":[{"@value":"Masaaki Muramatsu"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845803544849","@type":"Researcher","foaf:name":[{"@value":"Shigeru Kinoshita"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845803544839","@type":"Researcher","foaf:name":[{"@value":"Masamichi Abe"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845803544847","@type":"Researcher","foaf:name":[{"@value":"Hiroko Ikeda"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845803544834","@type":"Researcher","foaf:name":[{"@value":"Mariko Kashiwagi"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845803544832","@type":"Researcher","foaf:name":[{"@value":"Yixuan Song"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845803544845","@type":"Researcher","foaf:name":[{"@value":"Mayumi Ueta"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845803544841","@type":"Researcher","foaf:name":[{"@value":"Chie Sotozono"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845803544835","@type":"Researcher","foaf:name":[{"@value":"Zenro Ikezawa"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845803544836","@type":"Researcher","foaf:name":[{"@value":"Ryuichi Hasegawa"}],"jpcoar:affiliationName":[{"@value":"Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-11 Kamiyoga, Setagaya-ku, Tokyo"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"14622416"},{"@type":"EISSN","@value":"17448042"}],"prism:publicationName":[{"@value":"Pharmacogenomics"}],"dc:publisher":[{"@value":"Informa UK Limited"}],"prism:publicationDate":"2008-11","prism:volume":"9","prism:number":"11","prism:startingPage":"1617","prism:endingPage":"1622"},"reviewed":"false","url":[{"@id":"https://www.tandfonline.com/doi/pdf/10.2217/14622416.9.11.1617"}],"createdAt":"2008-11-20","modifiedAt":"2024-05-17","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Aged,%2080%20and%20over","dc:title":"Aged, 80 and over"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Adolescent","dc:title":"Adolescent"},{"@id":"https://cir.nii.ac.jp/all?q=Genotype","dc:title":"Genotype"},{"@id":"https://cir.nii.ac.jp/all?q=Allopurinol","dc:title":"Allopurinol"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Severity%20of%20Illness%20Index","dc:title":"Severity of Illness Index"},{"@id":"https://cir.nii.ac.jp/all?q=Young%20Adult","dc:title":"Young Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Asian%20People","dc:title":"Asian People"},{"@id":"https://cir.nii.ac.jp/all?q=Japan","dc:title":"Japan"},{"@id":"https://cir.nii.ac.jp/all?q=HLA-B%20Antigens","dc:title":"HLA-B Antigens"},{"@id":"https://cir.nii.ac.jp/all?q=Stevens-Johnson%20Syndrome","dc:title":"Stevens-Johnson Syndrome"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Anticonvulsants","dc:title":"Anticonvulsants"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Child","dc:title":"Child"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004231949674496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Predictive Factors Associated With Acute Ocular Involvement in Stevens-Johnson Syndrome and Toxic Epidermal 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Chinese"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565164527213824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Allopurinol suppresses expression of the regulatory T‐cell migration factors TARC/CCL17 and MDC/CCL22 in HaCaT keratinocytes via restriction of nuclear factor‐κB activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565167514907264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567184845272704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Analysis of Ocular Manifestation and Genetic Association of Allopurinol-Induced Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis in South Korea"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846640980799488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis – A Comprehensive Review and Guide to Therapy. I. Systemic Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848658473239296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A whole-genome association study of major determinants for allopurinol-related Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660608159104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>HLA‐B*1511</i> is a risk factor for carbamazepine‐induced Stevens‐Johnson syndrome and toxic epidermal necrolysis in Japanese patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848661475930112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Results of Detailed Investigations Into Stevens-Johnson Syndrome With Severe Ocular Complications"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861288124322944","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Validation of a genotyping technique for a surrogate marker of HLA-B58:01 for allopurinol-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in the Japanese population"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707396498688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Susceptibility Genes and HLA for Cold Medicine-Related SJS/TEN with SOC"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865816799391232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Differential Effects of HLA-B∗15:11 and HLA-A∗31:01 on Carbamazepine-Induced Cutaneous Adverse Reactions"}]},{"@id":"https://cir.nii.ac.jp/crid/1361978698490866176","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"HLA-B*58:01 and rs9263726 have a linkage, but not absolute linkage disequilibrium in Han Chinese population"}]},{"@id":"https://cir.nii.ac.jp/crid/1362541648444120064","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Human leukocyte antigen and idiosyncratic adverse drug reactions"}]},{"@id":"https://cir.nii.ac.jp/crid/1363949023327593856","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Docking simulations between drugs and HLA molecules associated with idiosyncratic drug toxicity"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204631924608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Genetic Markers and Danger Signals in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204632268800","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS): 11 years retrospective study in Thailand"},{"@language":"en","@value":"Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS): 11 years retrospective study in Thailand"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204632795136","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Stevens-Johnson syndrome and toxic epidermal necrolysis: The Food and Drug Administration adverse event reporting system, 2004-2013"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205178872448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Development of a Rapid and Inexpensive Assay for Detecting a Surrogate Genetic Polymorphism of <i>HLA-B*58:01</i>: A Partially Predictive but Useful Biomarker for Allopurinol-related Stevens-Johnson Syndrome/toxic Epidermal Necrolysis in Japanese"},{"@value":"Development of a Rapid and Inexpensive Assay for Detecting a Surrogate Genetic Polymorphism of HLA-B*58:01: A Partially Predictive but Useful Biomarker for Allopurinol-related Stevens-Johnson Syndrome/toxic Epidermal Necrolysis in Japanese"},{"@value":"Development of a rapid and inexpensive assay for detecting a surrogate genetic polymorphism of HLA-B∗58:01: a partially predictive but useful biomarker for allopurinol-related Stevens-Johnson syndrome/toxic epidermal necrolysis in Japanese"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205179415168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Recent Update of Pharmacogenomics in Drug-induced Severe Skin Reactions"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205179471232","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Population Differences in Major Functional Polymorphisms of Pharmacokinetics/pharmacodynamics-related Genes in Eastern Asians and Europeans: Implications in the Clinical Trials for Novel Drug Development"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205180719616","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Drug-Induced Idiosyncratic Hepatotoxicity: Prevention Strategy Developed after the Troglitazone Case"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205289565952","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Genetic susceptibility and pharmacogenomics of severe cutaneous adverse drug reactions"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205368414848","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"重症薬疹（スティーブンス・ジョンソン症候群及び中毒性表皮壊死症）のゲノム薬理学"},{"@language":"en","@value":"S12-2. Pharmacogenomics on Drug-induced Severe Cutaneous Reactions (Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis)"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206126782336","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Analysis of Body Constitution of Fifty-two Patients with Stevens-Johnson Syndrome (SJS) Using Kampo Medical Questionnaires: Prediction of SJS based on Body Constitution Using Decision Tree"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679610986240","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"A review of toxic epidermal necrolysis management in Japan"},{"@language":"en","@value":"A review of toxic epidermal necrolysis management in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679752583040","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical 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