{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388845910758784.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.1076701"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.1076701"}},{"identifier":{"@type":"NAID","@value":"80015733316"}}],"dc:title":[{"@value":"Role of Melanopsin in Circadian Responses to Light"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n                    Melanopsin has been proposed as an important photoreceptive molecule for the mammalian circadian system. Its importance in this role was tested in melanopsin knockout mice. These mice entrained to a light/dark cycle, phase-shifted after a light pulse, and increased circadian period when light intensity increased. Induction of the immediate-early gene c-\n                    <jats:italic>fos</jats:italic>\n                    was observed after a nighttime light pulse in both wild-type and knockout mice. However, the magnitude of these behavioral responses in knockout mice was 40% lower than in wild-type mice. Although melanopsin is not essential for the circadian clock to receive photic input, it contributes significantly to the magnitude of photic responses.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388845910758787","@type":"Researcher","foaf:name":[{"@value":"Norman F. Ruby"}],"jpcoar:affiliationName":[{"@value":"Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845910758790","@type":"Researcher","foaf:name":[{"@value":"Thomas J. Brennan"}],"jpcoar:affiliationName":[{"@value":"Deltagen, Inc., Redwood City, CA 94063, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845910758789","@type":"Researcher","foaf:name":[{"@value":"Xinmin Xie"}],"jpcoar:affiliationName":[{"@value":"Deltagen, Inc., Redwood City, CA 94063, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845910758786","@type":"Researcher","foaf:name":[{"@value":"Vinh Cao"}],"jpcoar:affiliationName":[{"@value":"Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845910758788","@type":"Researcher","foaf:name":[{"@value":"Paul Franken"}],"jpcoar:affiliationName":[{"@value":"Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845910758784","@type":"Researcher","foaf:name":[{"@value":"H. Craig Heller"}],"jpcoar:affiliationName":[{"@value":"Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388845910758785","@type":"Researcher","foaf:name":[{"@value":"Bruce F. O'Hara"}],"jpcoar:affiliationName":[{"@value":"Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"2002-12-13","prism:volume":"298","prism:number":"5601","prism:startingPage":"2211","prism:endingPage":"2213"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/science.1076701"}],"createdAt":"2002-12-12","modifiedAt":"2024-01-09","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050005822263150208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Reduced Light Response of Neuronal Firing Activity in the Suprachiasmatic Nucleus and Optic Nerve of Cryptochrome-Deficient 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