{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388845981565696.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.1537100100"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.1537100100"}}],"dc:title":[{"@value":"Bacteria–host communication: The language of hormones"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n                    The interbacterial communication system known as quorum sensing (QS)\n utilizes hormone-like compounds referred to as autoinducers to regulate\n bacterial gene expression. Enterohemorrhagic\n                    <jats:italic>Escherichia coli</jats:italic>\n                    (EHEC)\n serotype O157:H7 is the agent responsible for outbreaks of bloody diarrhea in\n several countries. We previously proposed that EHEC uses a QS regulatory\n system to “sense” that it is within the intestine and activate\n genes essential for intestinal colonization. The QS system used by EHEC is the\n LuxS/autoinducer 2 (AI-2) system extensively involved in interspecies\n communication. The autoinducer AI-2 is a furanosyl borate diester whose\n synthesis depends on the enzyme LuxS. Here we show that an EHEC\n                    <jats:italic>luxS</jats:italic>\n                    mutant, unable to produce the bacterial autoinducer, still responds to a\n eukaryotic cell signal to activate expression of its virulence genes. We have\n identified this signal as the hormone epinephrine and show that β- and\n α-adrenergic antagonists can block the bacterial response to this\n hormone. Furthermore, using purified and\n                    <jats:italic>in vitro</jats:italic>\n                    synthesized AI-2 we\n showed that AI-2 is not the autoinducer involved in the bacterial signaling.\n EHEC produces another, previously undescribed autoinducer (AI-3) whose\n synthesis depends on the presence of LuxS. These results imply a potential\n cross-communication between the\n                    <jats:italic>luxS</jats:italic>\n                    /AI-3 bacterial QS system and the\n epinephrine host signaling system. Given that eukaryotic cell-to-cell\n signaling typically occurs through hormones, and that bacterial cell-to-cell\n signaling occurs through QS, we speculate that QS might be a\n “language” by which bacteria and host cells communicate.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380013199291155457","@type":"Researcher","foaf:name":[{"@value":"Vanessa Sperandio"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, University of Texas\r Southwestern Medical Center, Dallas, TX 75390-9048; Departments of\r Microbiology and Immunology and\r Pediatrics, and\r Center for Vaccine Development, University of\r Maryland School of Medicine, Baltimore, MD 21201; and\r Department of Chemistry and Biochemistry,\r University of Maryland, College Park, MD 20742"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013199291155458","@type":"Researcher","foaf:name":[{"@value":"Alfredo G. Torres"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, University of Texas\r Southwestern Medical Center, Dallas, TX 75390-9048; Departments of\r Microbiology and Immunology and\r Pediatrics, and\r Center for Vaccine Development, University of\r Maryland School of Medicine, Baltimore, MD 21201; and\r Department of Chemistry and Biochemistry,\r University of Maryland, College Park, MD 20742"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013199291155459","@type":"Researcher","foaf:name":[{"@value":"Bruce Jarvis"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, University of Texas\r Southwestern Medical Center, Dallas, TX 75390-9048; Departments of\r Microbiology and Immunology and\r Pediatrics, and\r Center for Vaccine Development, University of\r Maryland School of Medicine, Baltimore, MD 21201; and\r Department of Chemistry and Biochemistry,\r University of Maryland, College Park, MD 20742"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013199291155328","@type":"Researcher","foaf:name":[{"@value":"James P. Nataro"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, University of Texas\r Southwestern Medical Center, Dallas, TX 75390-9048; Departments of\r Microbiology and Immunology and\r Pediatrics, and\r Center for Vaccine Development, University of\r Maryland School of Medicine, Baltimore, MD 21201; and\r Department of Chemistry and Biochemistry,\r University of Maryland, College Park, MD 20742"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013199291155456","@type":"Researcher","foaf:name":[{"@value":"James B. Kaper"}],"jpcoar:affiliationName":[{"@value":"Department of Microbiology, University of Texas\r Southwestern Medical Center, Dallas, TX 75390-9048; Departments of\r Microbiology and Immunology and\r Pediatrics, and\r Center for Vaccine Development, University of\r Maryland School of Medicine, Baltimore, MD 21201; and\r Department of Chemistry and Biochemistry,\r University of Maryland, College Park, MD 20742"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"2003-07-07","prism:volume":"100","prism:number":"15","prism:startingPage":"8951","prism:endingPage":"8956"},"reviewed":"false","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.1537100100"}],"createdAt":"2003-07-22","modifiedAt":"2022-04-25","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050845762641867904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Exposure of P. gingivalis to noradrenaline reduces bacterial growth and elevates ArgX protease activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285711328725248","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Biofilm Formation by<i>Helicobacter pylori</i>and Its Involvement for Antibiotic Resistance"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565169386944000","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Commensal Bacteria-Dependent Indole Production Enhances Epithelial Barrier Function in the Colon"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187437705600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Bile Acid-Induced Virulence Gene Expression of Vibrio parahaemolyticus Reveals a Novel Therapeutic Potential for Bile Acid Sequestrants"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092414219392","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Progress Overview of Bacterial Two-Component Regulatory Systems as Potential Targets for Antimicrobial Chemotherapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846642064414464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"QseC inhibition as an antivirulence approach for colitis-associated bacteria"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660451090688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Roles of cell division control factor SdiA: recognition of quorum sensing signals and modulation of transcription regulation targets"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679123182976","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A novel small regulatory RNA enhances cell motility in enterohemorrhagic <i>Escherichia coli</i>"},{"@value":"A novel small regulatory RNA enhances cell motility in enterohemorrhagic Escherichia coli"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679189157248","@type":"Article","resourceType":"学術雑誌論文(journal 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システム"}]},{"@id":"https://cir.nii.ac.jp/crid/1520019158915152512","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Non-pathogenic Heyndrickxia coagulans (Bacillus coagulans) 29-2E inhibits the virulence of pathogenic Salmonella Typhimurium by quorum-sensing 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