{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388846147277696.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.1077209"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.1077209"}},{"identifier":{"@type":"NAID","@value":"80015761879"}}],"dc:title":[{"@value":"Mutations in the\n            <i>DJ-1</i>\n            Gene Associated with Autosomal Recessive Early-Onset Parkinsonism"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            The\n            <jats:italic>DJ-1</jats:italic>\n            gene encodes a ubiquitous, highly conserved protein. Here, we show that\n            <jats:italic>DJ-1</jats:italic>\n            mutations are associated with PARK7, a monogenic form of human parkinsonism. The function of the DJ-1 protein remains unknown, but evidence suggests its involvement in the oxidative stress response. Our findings indicate that loss of DJ-1 function leads to neurodegeneration. Elucidating the physiological role of DJ-1 protein may promote understanding of the mechanisms of brain neuronal maintenance and pathogenesis of Parkinson's disease.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388846147277704","@type":"Researcher","foaf:name":[{"@value":"Vincenzo Bonifati"}],"jpcoar:affiliationName":[{"@value":"Genetic-Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands."},{"@value":"Department of Neurological Sciences, “La Sapienza” University, Viale dell'Università30, 00185 Rome, Italy."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846147277831","@type":"Researcher","foaf:name":[{"@value":"Patrizia Rizzu"}],"jpcoar:affiliationName":[{"@value":"Genetic-Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846147277824","@type":"Researcher","foaf:name":[{"@value":"Marijke J. van Baren"}],"jpcoar:affiliationName":[{"@value":"Genetic-Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846147277827","@type":"Researcher","foaf:name":[{"@value":"Onno Schaap"}],"jpcoar:affiliationName":[{"@value":"Genetic-Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846147277701","@type":"Researcher","foaf:name":[{"@value":"Guido J. Breedveld"}],"jpcoar:affiliationName":[{"@value":"Genetic-Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846147277697","@type":"Researcher","foaf:name":[{"@value":"Elmar Krieger"}],"jpcoar:affiliationName":[{"@value":"Centre for Molecular and Biomolecular Informatics, University Medical Center Nijmegen, Geert Grooteplein Zuid 30, 6525 GA Nijmegen, Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846147277825","@type":"Researcher","foaf:name":[{"@value":"Marieke C. J. Dekker"}],"jpcoar:affiliationName":[{"@value":"Genetic-Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846147277703","@type":"Researcher","foaf:name":[{"@value":"Ferdinando Squitieri"}],"jpcoar:affiliationName":[{"@value":"Neurogenetics Unit, IRCCS INM Neuromed, Località Camerelle, 86077 Pozzilli, Italy."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846147277700","@type":"Researcher","foaf:name":[{"@value":"Pablo Ibanez"}],"jpcoar:affiliationName":[{"@value":"INSERM U 289, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846147277829","@type":"Researcher","foaf:name":[{"@value":"Marijke Joosse"}],"jpcoar:affiliationName":[{"@value":"Genetic-Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846147277830","@type":"Researcher","foaf:name":[{"@value":"Jeroen W. van Dongen"}],"jpcoar:affiliationName":[{"@value":"Genetic-Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846147277702","@type":"Researcher","foaf:name":[{"@value":"Nicola Vanacore"}],"jpcoar:affiliationName":[{"@value":"Department of Neurological Sciences, “La Sapienza” University, Viale dell'Università30, 00185 Rome, Italy."},{"@value":"Laboratory of Epidemiology and Biostatistics, National Institute for Health, 00161 Roma, Italy."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846147277696","@type":"Researcher","foaf:name":[{"@value":"John C. van Swieten"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology, Erasmus Medical Center Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846147277698","@type":"Researcher","foaf:name":[{"@value":"Alexis Brice"}],"jpcoar:affiliationName":[{"@value":"INSERM U 289, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846147277705","@type":"Researcher","foaf:name":[{"@value":"Giuseppe Meco"}],"jpcoar:affiliationName":[{"@value":"Department of Neurological Sciences, “La Sapienza” University, Viale dell'Università30, 00185 Rome, Italy."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846147277826","@type":"Researcher","foaf:name":[{"@value":"Cornelia M. van Duijn"}],"jpcoar:affiliationName":[{"@value":"Genetic-Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846147277699","@type":"Researcher","foaf:name":[{"@value":"Ben A. Oostra"}],"jpcoar:affiliationName":[{"@value":"Genetic-Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands."}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846147277828","@type":"Researcher","foaf:name":[{"@value":"Peter Heutink"}],"jpcoar:affiliationName":[{"@value":"Genetic-Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"2003-01-10","prism:volume":"299","prism:number":"5604","prism:startingPage":"256","prism:endingPage":"259"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/science.1077209"}],"createdAt":"2003-01-10","modifiedAt":"2024-01-10","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335737311872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Identification and characterization of an oocyte factor required for development of porcine nuclear transfer embryos"}]},{"@id":"https://cir.nii.ac.jp/crid/1050025031480115456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Identification of the recognition sequence and target proteins for DJ-1 protease"},{"@value":"Identification of the recognition sequence and target proteins for DJ‐1 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association with autosomal dominant Parkinson's disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285709199395968","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Free radicals impair the anti-oxidative stress activity of DJ-1 through the formation of SDS-resistant dimer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285709472970624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285710464957056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"High levels of <scp>DJ</scp>‐1 protein and isoelectric point 6.3 isoform in sera of breast cancer 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