{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388846156544000.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1084/jem.189.11.1777"}},{"identifier":{"@type":"URI","@value":"https://rupress.org/jem/article-pdf/189/11/1777/1691660/99-0348.pdf"}},{"identifier":{"@type":"PMID","@value":"10359581"}},{"identifier":{"@type":"NAID","@value":"30017416712"}}],"dc:title":[{"@value":"MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Toll-like receptor 4 (TLR4) is a mammalian homologue of Drosophila Toll, a leucine-rich repeat molecule that can trigger innate responses against pathogens. The TLR4 gene has recently been shown to be mutated in C3H/HeJ and C57BL/10ScCr mice, both of which are low responders to lipopolysaccharide (LPS). TLR4 may be a long-sought receptor for LPS. However, transfection of TLR4 does not confer LPS responsiveness on a recipient cell line, suggesting a requirement for an additional molecule. Here, we report that a novel molecule, MD-2, is requisite for LPS signaling of TLR4. MD-2 is physically associated with TLR4 on the cell surface and confers responsiveness to LPS. MD-2 is thus a link between TLR4 and LPS signaling. Identification of this new receptor complex has potential implications for understanding host defense, as well as pathophysiologic, mechanisms.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388846156544003","@type":"Researcher","foaf:name":[{"@value":"Rintaro Shimazu"}],"jpcoar:affiliationName":[{"@value":"From the Department of Immunology, Saga Medical School, Saga, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846156544001","@type":"Researcher","foaf:name":[{"@value":"Sachiko Akashi"}],"jpcoar:affiliationName":[{"@value":"From the Department of Immunology, Saga Medical School, Saga, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846156544005","@type":"Researcher","foaf:name":[{"@value":"Hirotaka Ogata"}],"jpcoar:affiliationName":[{"@value":"From the Department of Immunology, Saga Medical School, Saga, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846156544000","@type":"Researcher","foaf:name":[{"@value":"Yoshinori Nagai"}],"jpcoar:affiliationName":[{"@value":"From the Department of Immunology, Saga Medical School, Saga, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846156544002","@type":"Researcher","foaf:name":[{"@value":"Kenji Fukudome"}],"jpcoar:affiliationName":[{"@value":"From the Department of Immunology, Saga Medical School, Saga, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846156544006","@type":"Researcher","foaf:name":[{"@value":"Kensuke Miyake"}],"jpcoar:affiliationName":[{"@value":"From the Department of Immunology, Saga Medical School, Saga, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846156544004","@type":"Researcher","foaf:name":[{"@value":"Masao Kimoto"}],"jpcoar:affiliationName":[{"@value":"From the Department of Immunology, Saga Medical School, Saga, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00221007"},{"@type":"EISSN","@value":"15409538"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00221007"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00221007"}],"prism:publicationName":[{"@value":"The Journal of Experimental Medicine"}],"dc:publisher":[{"@value":"Rockefeller University Press"}],"prism:publicationDate":"1999-06-07","prism:volume":"189","prism:number":"11","prism:startingPage":"1777","prism:endingPage":"1782"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://rupress.org/jem/article-pdf/189/11/1777/1691660/99-0348.pdf"}],"createdAt":"2002-07-26","modifiedAt":"2023-07-25","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Lipopolysaccharides","dc:title":"Lipopolysaccharides"},{"@id":"https://cir.nii.ac.jp/all?q=DNA,%20Complementary","dc:title":"DNA, Complementary"},{"@id":"https://cir.nii.ac.jp/all?q=Molecular%20Sequence%20Data","dc:title":"Molecular Sequence Data"},{"@id":"https://cir.nii.ac.jp/all?q=Lymphocyte%20Antigen%2096","dc:title":"Lymphocyte Antigen 96"},{"@id":"https://cir.nii.ac.jp/all?q=Receptors,%20Cell%20Surface","dc:title":"Receptors, Cell Surface"},{"@id":"https://cir.nii.ac.jp/all?q=Transfection","dc:title":"Transfection"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line","dc:title":"Cell Line"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Drosophila%20Proteins","dc:title":"Drosophila Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=RNA,%20Messenger","dc:title":"RNA, Messenger"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C3H","dc:title":"Mice, Inbred C3H"},{"@id":"https://cir.nii.ac.jp/all?q=Membrane%20Glycoproteins","dc:title":"Membrane Glycoproteins"},{"@id":"https://cir.nii.ac.jp/all?q=Base%20Sequence","dc:title":"Base Sequence"},{"@id":"https://cir.nii.ac.jp/all?q=Sequence%20Homology,%20Amino%20Acid","dc:title":"Sequence Homology, Amino Acid"},{"@id":"https://cir.nii.ac.jp/all?q=Toll-Like%20Receptors","dc:title":"Toll-Like Receptors"},{"@id":"https://cir.nii.ac.jp/all?q=NF-kappa%20B","dc:title":"NF-kappa B"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Toll-Like%20Receptor%204","dc:title":"Toll-Like Receptor 4"},{"@id":"https://cir.nii.ac.jp/all?q=Antigens,%20Surface","dc:title":"Antigens, Surface"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001335786210944","@type":"Article","resourceType":"学術雑誌論文(journal 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