{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388846231891072.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/nar/gkg137"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/nar/article-pdf/31/2/517/7038730/gkg137.pdf"}},{"identifier":{"@type":"PMID","@value":"12527759"}},{"identifier":{"@type":"NAID","@value":"80015771574"}}],"dc:title":[{"@value":"Mutagenic potentials of damaged nucleic acids produced by reactive oxygen/nitrogen species: approaches using synthetic oligonucleotides and nucleotides: SURVEY AND SUMMARY"}],"description":[{"notation":[{"@value":"DNA and DNA precursors (deoxyribonucleotides) suffer damage by reactive oxygen/nitrogen species. They are important mutagens for organisms, due to their endogenous formation. Damaged DNA and nucleotides cause alterations of the genetic information by the mispairing properties of the damaged bases, such as 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) and 2-hydroxyadenine. Here, the author reviews the mutagenic potentials of damaged bases in DNA and of damaged DNA precursors formed by reactive oxygen/nitrogen species, focusing on the results obtained with synthetic oligonucleotides and 2'-deoxyribonucleoside 5'-triphosphates."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1581980076663116160","@type":"Researcher","foaf:name":[{"@value":"H. Kamiya"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"13624962"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/03051048"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/03051048"}],"prism:publicationName":[{"@value":"Nucleic Acids Research"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2003-01-15","prism:volume":"31","prism:number":"2","prism:startingPage":"517","prism:endingPage":"531"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://academic.oup.com/nar/article-pdf/31/2/517/7038730/gkg137.pdf"}],"createdAt":"2003-01-15","modifiedAt":"2017-08-24","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Guanine","dc:title":"Guanine"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Repair","dc:title":"DNA Repair"},{"@id":"https://cir.nii.ac.jp/all?q=Guanosine%20Monophosphate","dc:title":"Guanosine Monophosphate"},{"@id":"https://cir.nii.ac.jp/all?q=Deoxyguanosine","dc:title":"Deoxyguanosine"},{"@id":"https://cir.nii.ac.jp/all?q=DNA","dc:title":"DNA"},{"@id":"https://cir.nii.ac.jp/all?q=DNA-Directed%20DNA%20Polymerase","dc:title":"DNA-Directed DNA Polymerase"},{"@id":"https://cir.nii.ac.jp/all?q=Reactive%20Nitrogen%20Species","dc:title":"Reactive Nitrogen Species"},{"@id":"https://cir.nii.ac.jp/all?q=8-Hydroxy-2'-Deoxyguanosine","dc:title":"8-Hydroxy-2'-Deoxyguanosine"},{"@id":"https://cir.nii.ac.jp/all?q=Mutation","dc:title":"Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Deoxyuracil%20Nucleotides","dc:title":"Deoxyuracil Nucleotides"},{"@id":"https://cir.nii.ac.jp/all?q=Reactive%20Oxygen%20Species","dc:title":"Reactive Oxygen Species"},{"@id":"https://cir.nii.ac.jp/all?q=DNA%20Damage","dc:title":"DNA Damage"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050304394133443200","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"NEIL1: The second DNA glycosylase involved in action-at-a-distance mutations induced by 8-oxo-7,8-dihydroguanine"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004230101291136","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Fluorescence Properties of 5‐(5,6‐Dimethoxybenzothiazol‐2‐yl)‐2′‐deoxyuridine (d<sup>bt</sup>U) and Oligodeoxyribonucleotides Containing d<sup>bt</sup>U"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142846633088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Artificial Host Molecules to Covalently Capture 8-Nitro-cGMP in Neutral Aqueous Solutions and in 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