{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388846262089088.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1182/blood-2008-01-132415"}},{"identifier":{"@type":"URI","@value":"http://ashpublications.org/blood/article-pdf/112/8/3355/1307269/zh802008003355.pdf"}}],"dc:title":[{"@value":"The majority of cutaneous marginal zone B-cell lymphomas expresses class-switched immunoglobulins and develops in a T-helper type 2 inflammatory environment"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Extranodal marginal zone B-cell lymphomas (MZBCLs) arise on a background of chronic inflammation resulting from organ-specific autoimmunity, infection, or by unknown causes. Well-known examples are salivary gland MZBCL in Sjögren's sialadenitis and gastric MZBCL in Helicobacter pylori gastritis. MZBCLs express CXCR3, a receptor for interferon-γ–induced chemokines highly expressed in the chronic inflammatory environment. The immunoglobulin (Ig) variable heavy/light chain (IgVH/IgVL) gene repertoire of salivary gland and gastric MZBCL appears restricted and frequently encodes B-cell receptors with rheumatoid factor reactivity. Primary cutaneous marginal zone B-cell lymphomas (PCMZLs) are regarded as the skin-involving counterparts of extranodal MZBCLs. Although PCMZLs have been associated with Borrelia burgdorferi dermatitis, PCMZLs generally arise because of unknown causes. We studied an extensive panel of PCMZLs and show that PCMZLs do not conform to the general profile of extranodal MZBCL. Whereas most noncutaneous MZBCLs express IgM, PCMZLs in majority express IgG, IgA, and IgE and do not show an obvious immunoglobulin repertoire bias. Furthermore, the isotype-switched PCMZLs lack CXCR3 and seem to arise in a different inflammatory environment, compared with other extranodal MZBCLs.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388846262089090","@type":"Researcher","foaf:name":[{"@value":"Febe van Maldegem"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands;"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846262089089","@type":"Researcher","foaf:name":[{"@value":"Remco van Dijk"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands;"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846262089093","@type":"Researcher","foaf:name":[{"@value":"Thera A. M. Wormhoudt"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands;"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846262089088","@type":"Researcher","foaf:name":[{"@value":"Philip M. Kluin"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands;"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846262089094","@type":"Researcher","foaf:name":[{"@value":"Rein Willemze"}],"jpcoar:affiliationName":[{"@value":"Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846262089095","@type":"Researcher","foaf:name":[{"@value":"Lorenzo Cerroni"}],"jpcoar:affiliationName":[{"@value":"Department of Dermatology, Medical University of Graz, Graz, Austria"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846262089092","@type":"Researcher","foaf:name":[{"@value":"Carel J. M. van Noesel"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands;"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846262089091","@type":"Researcher","foaf:name":[{"@value":"Richard J. Bende"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands;"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00064971"},{"@type":"EISSN","@value":"15280020"}],"prism:publicationName":[{"@value":"Blood"}],"dc:publisher":[{"@value":"American Society of Hematology"}],"prism:publicationDate":"2008-10-15","prism:volume":"112","prism:number":"8","prism:startingPage":"3355","prism:endingPage":"3361"},"reviewed":"false","url":[{"@id":"http://ashpublications.org/blood/article-pdf/112/8/3355/1307269/zh802008003355.pdf"}],"createdAt":"2008-08-08","modifiedAt":"2023-05-19","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050002212336078208","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576120944256768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204335210752","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A case of primary cutaneous marginal zone B-cell lymphoma with Russell bodies"},{"@language":"ja","@value":"Russell小体の出現を伴った皮膚原発marginal zone B－cell lymphomaの1例"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1182/blood-2008-01-132415"},{"@type":"CROSSREF","@value":"10.1038/srep13539_references_DOI_36Uv3nUz5q0BVUt9ZCVlMiZX3dC"},{"@type":"CROSSREF","@value":"10.5227/skincancer.25.168_references_DOI_36Uv3nUz5q0BVUt9ZCVlMiZX3dC"},{"@type":"CROSSREF","@value":"10.1182/blood.2022015851_references_DOI_36Uv3nUz5q0BVUt9ZCVlMiZX3dC"}]}