{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363388846337867136.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.atherosclerosis.2008.01.008"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021915008000646?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021915008000646?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"18343384"}}],"dc:title":[{"@value":"Dietary intake of n-3 polyunsaturated fatty acids is inversely associated with CRP levels, especially among male smokers"}],"description":[{"notation":[{"@value":"To examine whether dietary intake of n-3 polyunsaturated fatty acid (n-3PUFA) is associated with serum C-reactive protein (CRP) levels with regard to smoking status in the Japanese general population in a cross-sectional study.A total of 14,191 participants aged 40-69 years were enrolled and divided into quartile groups according to their intake of n-3PUFA. Multivariate-adjusted logarithm-transformed CRP levels were compared between the quartile groups with regard to smoking status after adjusting for traditional risk factors and intake of saturated fatty acids. Adjusted CRP levels were inversely associated with dietary intake of n-3PUFA for both the male subjects and female subjects (p0.05 for trend). A linear trend was not seen between intake of n-3PUFA and adjusted CRP levels in male nonsmokers. Adjusted CRP level in the lowest quartile group of n-3PUFA was significantly higher than the levels in other groups in male smokers.Sufficient dietary intake of n-3PUFA may attenuate inflammatory reaction and this effect is more evident among high-risk populations such as male smokers although the small numbers of female ex-smokers and nonsmokers limited statistical power to draw strong conclusions about these groups."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383388846337867140","@type":"Researcher","foaf:name":[{"@value":"Masaki Ohsawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846337867147","@type":"Researcher","foaf:name":[{"@value":"Kazuyoshi Itai"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846337867141","@type":"Researcher","foaf:name":[{"@value":"Toshiyuki Onoda"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846337867146","@type":"Researcher","foaf:name":[{"@value":"Kozo Tanno"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846337867136","@type":"Researcher","foaf:name":[{"@value":"Satoshi Sasaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846337867137","@type":"Researcher","foaf:name":[{"@value":"Motoyuki Nakamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846337867138","@type":"Researcher","foaf:name":[{"@value":"Akira Ogawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846337867139","@type":"Researcher","foaf:name":[{"@value":"Kiyomi Sakata"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846337867142","@type":"Researcher","foaf:name":[{"@value":"Kazuko Kawamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846337867145","@type":"Researcher","foaf:name":[{"@value":"Toru Kuribayashi"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846337867143","@type":"Researcher","foaf:name":[{"@value":"Yuki Yoshida"}]},{"@id":"https://cir.nii.ac.jp/crid/1383388846337867144","@type":"Researcher","foaf:name":[{"@value":"Akira Okayama"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00219150"}],"prism:publicationName":[{"@value":"Atherosclerosis"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2008-11","prism:volume":"201","prism:number":"1","prism:startingPage":"184","prism:endingPage":"191"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0021915008000646?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0021915008000646?httpAccept=text/plain"}],"createdAt":"2008-03-19","modifiedAt":"2025-11-03","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Health%20Status","dc:title":"Health Status"},{"@id":"https://cir.nii.ac.jp/all?q=Smoking","dc:title":"Smoking"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Health%20Surveys","dc:title":"Health Surveys"},{"@id":"https://cir.nii.ac.jp/all?q=Diet","dc:title":"Diet"},{"@id":"https://cir.nii.ac.jp/all?q=Cohort%20Studies","dc:title":"Cohort Studies"},{"@id":"https://cir.nii.ac.jp/all?q=C-Reactive%20Protein","dc:title":"C-Reactive Protein"},{"@id":"https://cir.nii.ac.jp/all?q=Cross-Sectional%20Studies","dc:title":"Cross-Sectional Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Sex%20Factors","dc:title":"Sex Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Japan","dc:title":"Japan"},{"@id":"https://cir.nii.ac.jp/all?q=Risk%20Factors","dc:title":"Risk Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Fatty%20Acids,%20Omega-3","dc:title":"Fatty Acids, Omega-3"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Life%20Style","dc:title":"Life Style"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050290537412763648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Association between Milk Intake and Incident Stroke among Japanese Community Dwellers : The Iwate-KENCO Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231547721472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The associations of C-reactive protein with serum levels of polyunsaturated fatty acids and trans fatty acids among middle-aged men from three 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