{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1363664919005026432.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3390/ijms20112634"}},{"identifier":{"@type":"URI","@value":"https://www.mdpi.com/1422-0067/20/11/2634/pdf"}},{"identifier":{"@type":"PMID","@value":"31146370"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"Galectin-9 Induces Mitochondria-Mediated Apoptosis of Esophageal Cancer In Vitro and In Vivo in a Xenograft Mouse Model"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Galectin-9 (Gal-9) enhances tumor immunity mediated by T cells, macrophages, and dendritic cells. Its expression level in various cancers correlates with prognosis. Furthermore, Gal-9 directly induces apoptosis in various cancers; however, its mechanism of action and bioactivity has not been clarified. We evaluated Gal-9 antitumor effect against esophageal squamous cell carcinoma (ESCC) to analyze the dynamics of apoptosis-related molecules, elucidate its mechanism of action, and identify relevant changes in miRNA expressions. KYSE-150 and KYSE-180 cells were treated with Gal-9 and their proliferation was evaluated. Gal-9 inhibited cell proliferation in a concentration-dependent manner. The xenograft mouse model established with KYSE-150 cells was administered with Gal-9 and significant suppression in the tumor growth observed. Gal-9 treatment of KYSE-150 cells increased the number of Annexin V-positive cells, activation of caspase-3, and collapse of mitochondrial potential, indicating apoptosis induction. c-Jun NH2-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38) phosphorylation were activated and could be involved in apoptosis. Therefore, Gal-9 induces mitochondria-mediated apoptosis of ESCC and inhibits cell proliferation in vitro and in vivo with JNK and p38 activation.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420001326222108288","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50769346"},{"@type":"NRID","@value":"1000050769346"},{"@type":"NRID","@value":"9000308729165"},{"@type":"NRID","@value":"9000413943346"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/alotig"}],"foaf:name":[{"@value":"Taiga Chiyo"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology and Neurology, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383664919005026560","@type":"Researcher","foaf:name":[{"@value":"Koji Fujita"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology and Neurology, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383664919005026439","@type":"Researcher","foaf:name":[{"@value":"Hisakazu Iwama"}],"jpcoar:affiliationName":[{"@value":"Life Science Research Center, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383664919005026436","@type":"Researcher","foaf:name":[{"@value":"Shintaro Fujihara"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology and Neurology, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383664919005026563","@type":"Researcher","foaf:name":[{"@value":"Tomoko Tadokoro"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology and Neurology, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383664919005026689","@type":"Researcher","foaf:name":[{"@value":"Kyoko Ohura"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology and Neurology, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383664919005026564","@type":"Researcher","foaf:name":[{"@value":"Takanori Matsui"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology and Neurology, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383664919005026565","@type":"Researcher","foaf:name":[{"@value":"Yasuhiro Goda"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology and Neurology, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383664919005026562","@type":"Researcher","foaf:name":[{"@value":"Nobuya Kobayashi"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology and Neurology, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383664919005026690","@type":"Researcher","foaf:name":[{"@value":"Noriko Nishiyama"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology and Neurology, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383664919005026566","@type":"Researcher","foaf:name":[{"@value":"Tatsuo Yachida"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology and Neurology, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801188446848","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60423430"},{"@type":"NRID","@value":"1000060423430"},{"@type":"NRID","@value":"9000261653649"},{"@type":"NRID","@value":"9000345290358"},{"@type":"NRID","@value":"9000350631575"},{"@type":"NRID","@value":"9000412365075"},{"@type":"NRID","@value":"9000001150045"},{"@type":"NRID","@value":"9000387917532"},{"@type":"NRID","@value":"9000243884234"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000007642"}],"foaf:name":[{"@value":"Asahiro Morishita"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology and Neurology, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801194204160","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10612476"},{"@type":"NRID","@value":"1000010612476"},{"@type":"NRID","@value":"9000325828042"},{"@type":"NRID","@value":"9000402943718"},{"@type":"NRID","@value":"9000415350232"},{"@type":"NRID","@value":"9000000573780"},{"@type":"NRID","@value":"9000308729160"},{"@type":"NRID","@value":"9000413572943"},{"@type":"NRID","@value":"9000413943344"},{"@type":"NRID","@value":"9000345290357"},{"@type":"NRID","@value":"9000414094223"},{"@type":"NRID","@value":"9000321626006"},{"@type":"NRID","@value":"9000243885012"},{"@type":"NRID","@value":"9000256891885"},{"@type":"NRID","@value":"9000240057834"},{"@type":"NRID","@value":"9000412365077"},{"@type":"NRID","@value":"9000326256756"},{"@type":"NRID","@value":"9000326256784"},{"@type":"NRID","@value":"9000243884235"},{"@type":"NRID","@value":"9000402041418"},{"@type":"NRID","@value":"9000412316951"},{"@type":"NRID","@value":"9000258708829"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0155527"}],"foaf:name":[{"@value":"Hideki Kobara"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology and Neurology, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383664919005026434","@type":"Researcher","foaf:name":[{"@value":"Hirohito Mori"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology and Neurology, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383664919005026433","@type":"Researcher","foaf:name":[{"@value":"Toshiro Niki"}],"jpcoar:affiliationName":[{"@value":"Department of Immunology and Immunopathology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383664919005026438","@type":"Researcher","foaf:name":[{"@value":"Mitsuomi Hirashima"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology and Neurology, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383664919005026561","@type":"Researcher","foaf:name":[{"@value":"Takashi Himoto"}],"jpcoar:affiliationName":[{"@value":"Department of Medical Technology, Kagawa Prefectural University of Health Sciences, 281-1, Hara, Mure-Cho, Takamatsu, Kagawa 761-0123, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1383664919005026432","@type":"Researcher","foaf:name":[{"@value":"Tsutomu Masaki"}],"jpcoar:affiliationName":[{"@value":"Department of Gastroenterology and Neurology, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14220067"}],"prism:publicationName":[{"@value":"International Journal of Molecular Sciences"}],"dc:publisher":[{"@value":"MDPI AG"}],"prism:publicationDate":"2019-05-29","prism:volume":"20","prism:number":"11","prism:startingPage":"2634"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://www.mdpi.com/1422-0067/20/11/2634/pdf"}],"createdAt":"2019-05-29","modifiedAt":"2025-10-11","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20BALB%20C","dc:title":"Mice, Inbred BALB C"},{"@id":"https://cir.nii.ac.jp/all?q=microRNA","dc:title":"microRNA"},{"@id":"https://cir.nii.ac.jp/all?q=Esophageal%20Neoplasms","dc:title":"Esophageal Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=MAP%20Kinase%20Signaling%20System","dc:title":"MAP Kinase Signaling System"},{"@id":"https://cir.nii.ac.jp/all?q=Galectins","dc:title":"Galectins"},{"@id":"https://cir.nii.ac.jp/all?q=apoptosis","dc:title":"apoptosis"},{"@id":"https://cir.nii.ac.jp/all?q=Antineoplastic%20Agents","dc:title":"Antineoplastic Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Apoptosis","dc:title":"Apoptosis"},{"@id":"https://cir.nii.ac.jp/all?q=Article","dc:title":"Article"},{"@id":"https://cir.nii.ac.jp/all?q=esophageal%20squamous%20cell%20carcinoma","dc:title":"esophageal squamous cell carcinoma"},{"@id":"https://cir.nii.ac.jp/all?q=Mitochondria","dc:title":"Mitochondria"},{"@id":"https://cir.nii.ac.jp/all?q=galectin-9","dc:title":"galectin-9"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line,%20Tumor","dc:title":"Cell Line, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Carcinoma,%20Squamous%20Cell","dc:title":"Carcinoma, Squamous Cell"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=JNK","dc:title":"JNK"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040000782023012864","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"19K16747"},{"@type":"JGN","@value":"JP19K16747"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K16747/"}],"notation":[{"@language":"ja","@value":"食道扁平上皮癌におけるガレクチン9の抗腫瘍作用の解明と標的microRNAの同定"},{"@language":"en","@value":"Antitumor effect of galectin-9 in esophageal squamous cell carcinoma and identification of target 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