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When cavitation bubbles generated by ultrasound oscillate and collapse, ROS are generated due to the high temperature and high pressure inside the bubble. By generating cavitation bubbles in a target tissue, it can be treated by the cytotoxicity of ROS, which can be further enhanced by a sonosensitizer. In SDT, the small treatment region by a single shot of HIFU results in a long treatment time, which needs to be reduced by improving the efficiency of ROS generation. ROS can be visualized by the sonochemiluminescence of luminol. In this study, a polyacrylamide gel soaked with luminol solution is used as a target of ultrasonic exposure. The effect of the duty cycle of HIFU exposure on ROS generation was investigated by capturing sonochemiluminescent light emission, and high-speed photography of cavitation bubbles.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1383664919112748679","@type":"Researcher","foaf:name":[{"@value":"Kenki Tsukahara"}]},{"@id":"https://cir.nii.ac.jp/crid/1383664919112748677","@type":"Researcher","foaf:name":[{"@value":"Shin-ichiro 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